Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.

The controlled delivery of antibiotics, anti-inflammatory agents, or chemotherapeutic agents to the periodontal site is a recognized strategy to improve the efficiency of regenerative processes of hard tissues. A novel approach based on the trapping of tetracycline hydrochloride–loaded particles...

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Main Authors:	Wan Abdul Khodir, WK, Guarino, V, Alvarez Perez, MA, Cafiero, C, Ambrosio, L
Format:	Article
Language:	English
Published:	SAGE 2013
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/28713/ http://irep.iium.edu.my/28713/ http://irep.iium.edu.my/28713/ http://irep.iium.edu.my/28713/1/trapping_TCH_nanofibers.pdf

id	iium-28713
recordtype	eprints
spelling	iium-287132014-02-04T06:26:26Z http://irep.iium.edu.my/28713/ Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy. Wan Abdul Khodir, WK Guarino, V Alvarez Perez, MA Cafiero, C Ambrosio, L Q Science (General) The controlled delivery of antibiotics, anti-inflammatory agents, or chemotherapeutic agents to the periodontal site is a recognized strategy to improve the efficiency of regenerative processes of hard tissues. A novel approach based on the trapping of tetracycline hydrochloride–loaded particles in polycaprolactone nanofibers was used to guide the regeneration processes of periodontal tissue at the gum interface. Chitosan nanoparticles loaded with different levels of tetracycline hydrochloride (up to 5% wt) were prepared by solution nebulization induced by electrical forces (i.e. electrospraying). The fine tuning of process parameters allows to obtain nanoparticles with tailored sizes ranging from 0.485 ± 0.147 μm to 0.639 ± 0.154 μm. The tetracycline hydrochloride release profile had a predominant burst effect for the first 70% of release followed by a relatively slow release over 24 h, which is promising for oral drug delivery. We also demonstrated that trapping tetracycline hydrochloride–loaded particles with submicrometer diameters into a polycaprolactone fiber network contributed to slowing the release of tetracycline hydrochloride from the nanoparticles, thus providing a more prolonged release in the periodontal pocket during clinical therapy. Preliminary studies on human mesenchymal stem cells confirm the viability of cells up to 5 days after culture, and thereby, validate the use of nanoparticle-/nanofiber-integrated systems in periodontal therapies SAGE 2013-05-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28713/1/trapping_TCH_nanofibers.pdf Wan Abdul Khodir, WK and Guarino, V and Alvarez Perez, MA and Cafiero, C and Ambrosio, L (2013) Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy. Journal of Bioactive and Compatible Polymer, 28 (3). pp. 258-273. ISSN 0883-9115 http://jbc.sagepub.com/content/28/3/258.full.pdf+html 10.1177/0883911513481133
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Wan Abdul Khodir, WK Guarino, V Alvarez Perez, MA Cafiero, C Ambrosio, L Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.
description	The controlled delivery of antibiotics, anti-inflammatory agents, or chemotherapeutic agents to the periodontal site is a recognized strategy to improve the efficiency of regenerative processes of hard tissues. A novel approach based on the trapping of tetracycline hydrochloride–loaded particles in polycaprolactone nanofibers was used to guide the regeneration processes of periodontal tissue at the gum interface. Chitosan nanoparticles loaded with different levels of tetracycline hydrochloride (up to 5% wt) were prepared by solution nebulization induced by electrical forces (i.e. electrospraying). The fine tuning of process parameters allows to obtain nanoparticles with tailored sizes ranging from 0.485 ± 0.147 μm to 0.639 ± 0.154 μm. The tetracycline hydrochloride release profile had a predominant burst effect for the first 70% of release followed by a relatively slow release over 24 h, which is promising for oral drug delivery. We also demonstrated that trapping tetracycline hydrochloride–loaded particles with submicrometer diameters into a polycaprolactone fiber network contributed to slowing the release of tetracycline hydrochloride from the nanoparticles, thus providing a more prolonged release in the periodontal pocket during clinical therapy. Preliminary studies on human mesenchymal stem cells confirm the viability of cells up to 5 days after culture, and thereby, validate the use of nanoparticle-/nanofiber-integrated systems in periodontal therapies
format	Article
author	Wan Abdul Khodir, WK Guarino, V Alvarez Perez, MA Cafiero, C Ambrosio, L
author_facet	Wan Abdul Khodir, WK Guarino, V Alvarez Perez, MA Cafiero, C Ambrosio, L
author_sort	Wan Abdul Khodir, WK
title	Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.
title_short	Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.
title_full	Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.
title_fullStr	Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.
title_full_unstemmed	Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.
title_sort	trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.
publisher	SAGE
publishDate	2013
url	http://irep.iium.edu.my/28713/ http://irep.iium.edu.my/28713/ http://irep.iium.edu.my/28713/ http://irep.iium.edu.my/28713/1/trapping_TCH_nanofibers.pdf
first_indexed	2023-09-18T20:42:17Z
last_indexed	2023-09-18T20:42:17Z
_version_	1777409444645175296

Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.

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