Trapping tetracycline loaded nanoparticles into polycaprolactone fiber networks for periodontal regeneration therapy.
The controlled delivery of antibiotics, anti-inflammatory agents, or chemotherapeutic agents to the periodontal site is a recognized strategy to improve the efficiency of regenerative processes of hard tissues. A novel approach based on the trapping of tetracycline hydrochloride–loaded particles...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/28713/ http://irep.iium.edu.my/28713/ http://irep.iium.edu.my/28713/ http://irep.iium.edu.my/28713/1/trapping_TCH_nanofibers.pdf |
| Summary: | The controlled delivery of antibiotics, anti-inflammatory agents, or chemotherapeutic agents to
the periodontal site is a recognized strategy to improve the efficiency of regenerative processes of
hard tissues. A novel approach based on the trapping of tetracycline hydrochloride–loaded particles
in polycaprolactone nanofibers was used to guide the regeneration processes of periodontal
tissue at the gum interface. Chitosan nanoparticles loaded with different levels of tetracycline
hydrochloride (up to 5% wt) were prepared by solution nebulization induced by electrical forces
(i.e. electrospraying). The fine tuning of process parameters allows to obtain nanoparticles with
tailored sizes ranging from 0.485 ± 0.147 μm to 0.639 ± 0.154 μm. The tetracycline hydrochloride
release profile had a predominant burst effect for the first 70% of release followed by a relatively
slow release over 24 h, which is promising for oral drug delivery. We also demonstrated that
trapping tetracycline hydrochloride–loaded particles with submicrometer diameters into a
polycaprolactone fiber network contributed to slowing the release of tetracycline hydrochloride
from the nanoparticles, thus providing a more prolonged release in the periodontal pocket during
clinical therapy. Preliminary studies on human mesenchymal stem cells confirm the viability of
cells up to 5 days after culture, and thereby, validate the use of nanoparticle-/nanofiber-integrated
systems in periodontal therapies |
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