Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases

Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases

products, including proteases. The role of these proteases in the melioidosis, however, remains obscure. Previous findings have hinted at the inherent pathogenicity of the protease during B. pseudomallei K96243 infection. We chose to study the two major families peptidases, i.e. serine peptidases an...

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Main Authors: Muhamad Bunnori, Noraslinda, Mohamed, Rahmah
Format: Article
Language:English
Published: Elsevier Ltd. 2012
Subjects:
Q350 Information theory
Online Access:http://irep.iium.edu.my/28704/
http://irep.iium.edu.my/28704/
http://irep.iium.edu.my/28704/
http://irep.iium.edu.my/28704/1/1-s2.0-S1877050912005881-main.pdf
id iium-28704
recordtype eprints
spelling iium-287042013-02-13T08:33:39Z http://irep.iium.edu.my/28704/ Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases Muhamad Bunnori, Noraslinda Mohamed, Rahmah Q350 Information theory products, including proteases. The role of these proteases in the melioidosis, however, remains obscure. Previous findings have hinted at the inherent pathogenicity of the protease during B. pseudomallei K96243 infection. We chose to study the two major families peptidases, i.e. serine peptidases and metallopeptidases present in B. pseudomallei K96243. The data mining revealed eighty ORFs (open reading frame) that potentially code for these peptidases and have prominent homology with B. pseudomallei K96243 based on prediction of function by bioinformatics approach. The annotations and classification lead forty eight and thirty two putative peptidases belong to serine peptidase and metallopeptidase,respectively. The distribution of 98% from the identified putative peptidase belongs to endopeptidases (EC 3.4.21. and EC 3.4.24.) and exopeptidases (EC 3.4.11., EC 3.4.13., EC 3.4.14., EC 3.4.16. and EC 3.4.17) and another 2% belong to EC 3.5. Elsevier Ltd. 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28704/1/1-s2.0-S1877050912005881-main.pdf Muhamad Bunnori, Noraslinda and Mohamed, Rahmah (2012) Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases. Procedia Computer Science, 11. pp. 36-42. ISSN 1877-0509 http://www.sciencedirect.com/science/article/pii/S1877050912005881 10.1016/j.procs.2012.09.005
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic Q350 Information theory
spellingShingle Q350 Information theory
Muhamad Bunnori, Noraslinda
Mohamed, Rahmah
Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases
description products, including proteases. The role of these proteases in the melioidosis, however, remains obscure. Previous findings have hinted at the inherent pathogenicity of the protease during B. pseudomallei K96243 infection. We chose to study the two major families peptidases, i.e. serine peptidases and metallopeptidases present in B. pseudomallei K96243. The data mining revealed eighty ORFs (open reading frame) that potentially code for these peptidases and have prominent homology with B. pseudomallei K96243 based on prediction of function by bioinformatics approach. The annotations and classification lead forty eight and thirty two putative peptidases belong to serine peptidase and metallopeptidase,respectively. The distribution of 98% from the identified putative peptidase belongs to endopeptidases (EC 3.4.21. and EC 3.4.24.) and exopeptidases (EC 3.4.11., EC 3.4.13., EC 3.4.14., EC 3.4.16. and EC 3.4.17) and another 2% belong to EC 3.5.
format Article
author Muhamad Bunnori, Noraslinda
Mohamed, Rahmah
author_facet Muhamad Bunnori, Noraslinda
Mohamed, Rahmah
author_sort Muhamad Bunnori, Noraslinda
title Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases
title_short Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases
title_full Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases
title_fullStr Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases
title_full_unstemmed Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases
title_sort identification and characterization of burkholderia pseudomallei k96243 serine and metallopeptidases
publisher Elsevier Ltd.
publishDate 2012
url http://irep.iium.edu.my/28704/
http://irep.iium.edu.my/28704/
http://irep.iium.edu.my/28704/
http://irep.iium.edu.my/28704/1/1-s2.0-S1877050912005881-main.pdf
first_indexed 2023-09-18T20:42:16Z
last_indexed 2023-09-18T20:42:16Z
_version_ 1777409443746545664

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