E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53

E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53

E2FBP1/DRIL1 is an AT-rich interaction domain DNAbinding protein and is ubiquitously expressed in various tissues. It has been shown that Bright, the mouse orthologue of E2FBP1/DRIL1, exhibits sequence-specific DNA binding and regulates immunoglobulin transcription. Here we show a novel connection b...

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Main Authors: Ma, Kaiwen, Araki, Keigo, Arief Ichwan, Solachuddin Jauhari
Format: Article
Language:English
Published: American Association for Cancer Research 2003
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/28001/
http://irep.iium.edu.my/28001/
http://irep.iium.edu.my/28001/
http://irep.iium.edu.my/28001/1/438.pdf
id iium-28001
recordtype eprints
spelling iium-280012013-02-13T21:19:47Z http://irep.iium.edu.my/28001/ E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53 Ma, Kaiwen Araki, Keigo Arief Ichwan, Solachuddin Jauhari RB Pathology E2FBP1/DRIL1 is an AT-rich interaction domain DNAbinding protein and is ubiquitously expressed in various tissues. It has been shown that Bright, the mouse orthologue of E2FBP1/DRIL1, exhibits sequence-specific DNA binding and regulates immunoglobulin transcription. Here we show a novel connection between E2FBP1/ DRIL1 and the p53 tumor suppressor, a key regulator of growth arrest or apoptosis in response to cellular stress. We found a putative p53-binding site, which specifically responded to p53, in the second intron of the E2FBP1/ DRIL1 gene. E2FBP1/DRIL1was induced by p53 and upregulated following DNA damage caused by UV radiation or doxorubicin treatment in a manner dependent on endogenous p53. The ectopic expression of E2FBP1/ DRIL1 induced growth arrest in U2OS cells expressing normal p53, but not Saos-2 cells lacking p53. These results suggest that E2FBP1/DRIL1 may play a role in growth suppression mediated by p53. American Association for Cancer Research 2003-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28001/1/438.pdf Ma, Kaiwen and Araki, Keigo and Arief Ichwan, Solachuddin Jauhari (2003) E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53. Molecular Cancer Research, 1 (6). pp. 438-444. ISSN 1541-7786 http://mcr.aacrjournals.org/content/1/6.toc PMID: 12692263
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RB Pathology
spellingShingle RB Pathology
Ma, Kaiwen
Araki, Keigo
Arief Ichwan, Solachuddin Jauhari
E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53
description E2FBP1/DRIL1 is an AT-rich interaction domain DNAbinding protein and is ubiquitously expressed in various tissues. It has been shown that Bright, the mouse orthologue of E2FBP1/DRIL1, exhibits sequence-specific DNA binding and regulates immunoglobulin transcription. Here we show a novel connection between E2FBP1/ DRIL1 and the p53 tumor suppressor, a key regulator of growth arrest or apoptosis in response to cellular stress. We found a putative p53-binding site, which specifically responded to p53, in the second intron of the E2FBP1/ DRIL1 gene. E2FBP1/DRIL1was induced by p53 and upregulated following DNA damage caused by UV radiation or doxorubicin treatment in a manner dependent on endogenous p53. The ectopic expression of E2FBP1/ DRIL1 induced growth arrest in U2OS cells expressing normal p53, but not Saos-2 cells lacking p53. These results suggest that E2FBP1/DRIL1 may play a role in growth suppression mediated by p53.
format Article
author Ma, Kaiwen
Araki, Keigo
Arief Ichwan, Solachuddin Jauhari
author_facet Ma, Kaiwen
Araki, Keigo
Arief Ichwan, Solachuddin Jauhari
author_sort Ma, Kaiwen
title E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53
title_short E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53
title_full E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53
title_fullStr E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53
title_full_unstemmed E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53
title_sort e2fbp1/dril1, an at-rich interaction domain-family transcription factor, is regulated by p53
publisher American Association for Cancer Research
publishDate 2003
url http://irep.iium.edu.my/28001/
http://irep.iium.edu.my/28001/
http://irep.iium.edu.my/28001/
http://irep.iium.edu.my/28001/1/438.pdf
first_indexed 2023-09-18T20:41:26Z
last_indexed 2023-09-18T20:41:26Z
_version_ 1777409391940599808

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