Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine

Ketamine abuse is on the increase in Malaysia. Neurodegenerative change following ketamine use results in debilitating behavioural and cognitive dysfunctions. These changes are thought to be the consequences of network and cellular disorganization and degeneration in the brain involving areas such...

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Main Authors:	Mohd Shafri, Mohd Affendi, Mat Jais, Abdul Manan, Md Jaffri, Juliana, Min , Kyu Kim, Ithnin, Hairuszah, Mohamed, Farahidah
Format:	Article
Language:	English
Published:	Academic Sciences 2012
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/27822/ http://irep.iium.edu.my/27822/ http://irep.iium.edu.my/27822/1/Cresyl_violet_staining_to_assess_neuroprotective.pdf

id	iium-27822
recordtype	eprints
spelling	iium-278222013-12-14T07:21:47Z http://irep.iium.edu.my/27822/ Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine Mohd Shafri, Mohd Affendi Mat Jais, Abdul Manan Md Jaffri, Juliana Min , Kyu Kim Ithnin, Hairuszah Mohamed, Farahidah R Medicine (General) Ketamine abuse is on the increase in Malaysia. Neurodegenerative change following ketamine use results in debilitating behavioural and cognitive dysfunctions. These changes are thought to be the consequences of network and cellular disorganization and degeneration in the brain involving areas such as hippocampus. Ketamine works by blocking NMDA receptor and hence ketamine research has value in study on NMDA-related neurological disorders such as schizophrenia. This work study the histological change in rats brain which was exposed to ketamine and the effect of treating ketamine-exposed rats with haruan traditional extract (HTE) a substance which has been shown to have positive neuroregenerative function in cell culture study. The changes were studied using cresyl violet and parameters such as pathological score, dead cell count and degenerative change were evaluated. It was demonstrated that ketamine influences these parameters in exposure length-dependent manners and degenerative change could be ameliorated by supplementation with haruan therapeutic extract (HTE) pre-damage induction but not post-damage induction. The result adds to the growing number of evidence on neuroplasticity, and the possible role of non-endogenous substances in protecting as well as inducing genesis of neurons for diseases that share similar pattern of neurological change as ketamine-abused subjects. Academic Sciences 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/27822/1/Cresyl_violet_staining_to_assess_neuroprotective.pdf Mohd Shafri, Mohd Affendi and Mat Jais, Abdul Manan and Md Jaffri, Juliana and Min , Kyu Kim and Ithnin, Hairuszah and Mohamed, Farahidah (2012) Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (4). pp. 163-168. ISSN 0975-1491 http://www.ijppsjournal.com/Vol4Issue4/4747.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Mohd Shafri, Mohd Affendi Mat Jais, Abdul Manan Md Jaffri, Juliana Min , Kyu Kim Ithnin, Hairuszah Mohamed, Farahidah Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
description	Ketamine abuse is on the increase in Malaysia. Neurodegenerative change following ketamine use results in debilitating behavioural and cognitive dysfunctions. These changes are thought to be the consequences of network and cellular disorganization and degeneration in the brain involving areas such as hippocampus. Ketamine works by blocking NMDA receptor and hence ketamine research has value in study on NMDA-related neurological disorders such as schizophrenia. This work study the histological change in rats brain which was exposed to ketamine and the effect of treating ketamine-exposed rats with haruan traditional extract (HTE) a substance which has been shown to have positive neuroregenerative function in cell culture study. The changes were studied using cresyl violet and parameters such as pathological score, dead cell count and degenerative change were evaluated. It was demonstrated that ketamine influences these parameters in exposure length-dependent manners and degenerative change could be ameliorated by supplementation with haruan therapeutic extract (HTE) pre-damage induction but not post-damage induction. The result adds to the growing number of evidence on neuroplasticity, and the possible role of non-endogenous substances in protecting as well as inducing genesis of neurons for diseases that share similar pattern of neurological change as ketamine-abused subjects.
format	Article
author	Mohd Shafri, Mohd Affendi Mat Jais, Abdul Manan Md Jaffri, Juliana Min , Kyu Kim Ithnin, Hairuszah Mohamed, Farahidah
author_facet	Mohd Shafri, Mohd Affendi Mat Jais, Abdul Manan Md Jaffri, Juliana Min , Kyu Kim Ithnin, Hairuszah Mohamed, Farahidah
author_sort	Mohd Shafri, Mohd Affendi
title	Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_short	Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_full	Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_fullStr	Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_full_unstemmed	Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine
title_sort	cresyl violet staining to assess neuroprotective and euroregenerative effects of haruan traditional extract against eurodegenerative damage of ketamine
publisher	Academic Sciences
publishDate	2012
url	http://irep.iium.edu.my/27822/ http://irep.iium.edu.my/27822/ http://irep.iium.edu.my/27822/1/Cresyl_violet_staining_to_assess_neuroprotective.pdf
first_indexed	2023-09-18T20:41:13Z
last_indexed	2023-09-18T20:41:13Z
_version_	1777409378320646144

Cresyl violet staining to assess neuroprotective and euroregenerative effects of Haruan traditional extract against eurodegenerative damage of ketamine

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