Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng

Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis (Lour) Spreng was carried out to delineate the presence of its chemical constituents like Alkaloid, Flavonoid, Saponin, Triterpenoid, Steroid, and Phenolic. Acute oral toxicity at one dose level of...

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Main Authors:	Ramli, Norazsida, Oothuman, Pakeer, Bakhtiar, M. Taher, El-Hady Sayed Ahmed, Hassan Mohammed
Format:	Conference or Workshop Item
Language:	English English
Published:	2012
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/27434/ http://irep.iium.edu.my/27434/1/27434.pdf http://irep.iium.edu.my/27434/3/27434_poster.pdf

id	iium-27434
recordtype	eprints
spelling	iium-274342017-07-06T01:22:00Z http://irep.iium.edu.my/27434/ Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng Ramli, Norazsida Oothuman, Pakeer Bakhtiar, M. Taher El-Hady Sayed Ahmed, Hassan Mohammed RS Pharmacy and materia medica Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis (Lour) Spreng was carried out to delineate the presence of its chemical constituents like Alkaloid, Flavonoid, Saponin, Triterpenoid, Steroid, and Phenolic. Acute oral toxicity at one dose level of 5000 mg/kg as per OECD Guideline for Testing of Chemicals 423 was conducted to evaluate the safeness of this extract to be consumed by humans. 20 mice were divided into one control group and one experimental group. All the mice were observed for signs of toxicity, mortality, weight changes and gross pathological changes. Results on phytochemical analysis showed only flavanoid was present in the extract. The acute oral toxicity test revealed that no mortality or evidence of adverse effects were seen in the treated mice. Studies on histopathological examination of kidneys and liver showed normal architecture suggesting no morphological changes. Thus this ethanolic extract of leave P. amboinensis can be considered as safe as it did not cause either any lethality or adverse changes in mice. 2012 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/27434/1/27434.pdf application/pdf en http://irep.iium.edu.my/27434/3/27434_poster.pdf Ramli, Norazsida and Oothuman, Pakeer and Bakhtiar, M. Taher and El-Hady Sayed Ahmed, Hassan Mohammed (2012) Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng. In: 13th Medicinal & Aromatic Seminar 2012, 25th-26th September 2012, Sunway Putra Hotel, Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ramli, Norazsida Oothuman, Pakeer Bakhtiar, M. Taher El-Hady Sayed Ahmed, Hassan Mohammed Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
description	Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis (Lour) Spreng was carried out to delineate the presence of its chemical constituents like Alkaloid, Flavonoid, Saponin, Triterpenoid, Steroid, and Phenolic. Acute oral toxicity at one dose level of 5000 mg/kg as per OECD Guideline for Testing of Chemicals 423 was conducted to evaluate the safeness of this extract to be consumed by humans. 20 mice were divided into one control group and one experimental group. All the mice were observed for signs of toxicity, mortality, weight changes and gross pathological changes. Results on phytochemical analysis showed only flavanoid was present in the extract. The acute oral toxicity test revealed that no mortality or evidence of adverse effects were seen in the treated mice. Studies on histopathological examination of kidneys and liver showed normal architecture suggesting no morphological changes. Thus this ethanolic extract of leave P. amboinensis can be considered as safe as it did not cause either any lethality or adverse changes in mice.
format	Conference or Workshop Item
author	Ramli, Norazsida Oothuman, Pakeer Bakhtiar, M. Taher El-Hady Sayed Ahmed, Hassan Mohammed
author_facet	Ramli, Norazsida Oothuman, Pakeer Bakhtiar, M. Taher El-Hady Sayed Ahmed, Hassan Mohammed
author_sort	Ramli, Norazsida
title	Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_short	Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_full	Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_fullStr	Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_full_unstemmed	Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
title_sort	pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of plectranthus amboinensis (lour) spreng
publishDate	2012
url	http://irep.iium.edu.my/27434/ http://irep.iium.edu.my/27434/1/27434.pdf http://irep.iium.edu.my/27434/3/27434_poster.pdf
first_indexed	2023-09-18T20:40:46Z
last_indexed	2023-09-18T20:40:46Z
_version_	1777409349522554880

Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng

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