Salivary and serum antioxidant activity in patients with acute coronary syndrome

Introduction: Oxidative stress has been implicated in the pathogenesis of many diseases, including cardiovascular diseases. However, much less is understood about the redox status of patients with acute coronary syndrome (ACS). The present study was, therefore, designed to evaluate the redox statu...

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Main Authors:	Gulati, Yogesh, Narain, Varun Shanker, Saxena, Anil Kumar, Nigam, PK, Ali, Bashir
Format:	Article
Language:	English
Published:	Faculty of Medicine, International Islamic University Malaysia 2012
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/27277/ http://irep.iium.edu.my/27277/ http://irep.iium.edu.my/27277/1/Publication_IMJM_2012.pdf

id	iium-27277
recordtype	eprints
spelling	iium-272772012-12-06T01:47:39Z http://irep.iium.edu.my/27277/ Salivary and serum antioxidant activity in patients with acute coronary syndrome Gulati, Yogesh Narain, Varun Shanker Saxena, Anil Kumar Nigam, PK Ali, Bashir R Medicine (General) Introduction: Oxidative stress has been implicated in the pathogenesis of many diseases, including cardiovascular diseases. However, much less is understood about the redox status of patients with acute coronary syndrome (ACS). The present study was, therefore, designed to evaluate the redox status of patients with ACS prior to and following therapy as compared to age-matched healthy individuals by monitoring the antioxidant potential of serum and saliva as biomarkers of oxidative stress and evaluating their likely correlation with the clinical status of the patients. Methods: A total of 33 patients (29-78 year old, male) with the diagnosis of ACS and age-matched 16 healthy male (control) were included in the study. The diagnosis of ACS was based on the clinical presentation, ECG and serum cardiac biomarkers. These patients were grouped as acute myocardial infarction with ST-segment elevation subtype (STEMI, n=24) and non-ST-segment elevation myocardial infarction subtype (NSTEMI, n=9). Serum and salivary antioxidant activity (AOA) were determined spectrophotometrically. Results: Antioxidant defense, as reflected by lower total AOA in saliva and serum, was found to be significantly attenuated in patients with ACS as compared to control subjects, indicating an increased oxidative stress. The decrease in AOA was more conspicuous in patients with STEMI as compared to non-NSTEMI suggesting more oxidative stress in the former is associated with the severity of the disease, including tissue necrosis in STEMI patients. Drug treatment to ACS patients for a short-term period (4-6 days) elicited no significant improvement in their AOA. However, ACS patients receiving longterm drug treatment (4-5 weeks) exhibited a significant increase in AOA as well as an improvement in the clinical status. Conclusion: This preliminary study supports the role of oxidative stress in the pathogenesis of ACS and the use of salivary and serum AOA as a potential marker of the redox status and disease severity. Faculty of Medicine, International Islamic University Malaysia 2012-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/27277/1/Publication_IMJM_2012.pdf Gulati, Yogesh and Narain, Varun Shanker and Saxena, Anil Kumar and Nigam, PK and Ali, Bashir (2012) Salivary and serum antioxidant activity in patients with acute coronary syndrome. International Medical Journal Malaysia, 11 (2). pp. 35-38. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2011%20No%202/Vol11No2%20Pg35-38.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Gulati, Yogesh Narain, Varun Shanker Saxena, Anil Kumar Nigam, PK Ali, Bashir Salivary and serum antioxidant activity in patients with acute coronary syndrome
description	Introduction: Oxidative stress has been implicated in the pathogenesis of many diseases, including cardiovascular diseases. However, much less is understood about the redox status of patients with acute coronary syndrome (ACS). The present study was, therefore, designed to evaluate the redox status of patients with ACS prior to and following therapy as compared to age-matched healthy individuals by monitoring the antioxidant potential of serum and saliva as biomarkers of oxidative stress and evaluating their likely correlation with the clinical status of the patients. Methods: A total of 33 patients (29-78 year old, male) with the diagnosis of ACS and age-matched 16 healthy male (control) were included in the study. The diagnosis of ACS was based on the clinical presentation, ECG and serum cardiac biomarkers. These patients were grouped as acute myocardial infarction with ST-segment elevation subtype (STEMI, n=24) and non-ST-segment elevation myocardial infarction subtype (NSTEMI, n=9). Serum and salivary antioxidant activity (AOA) were determined spectrophotometrically. Results: Antioxidant defense, as reflected by lower total AOA in saliva and serum, was found to be significantly attenuated in patients with ACS as compared to control subjects, indicating an increased oxidative stress. The decrease in AOA was more conspicuous in patients with STEMI as compared to non-NSTEMI suggesting more oxidative stress in the former is associated with the severity of the disease, including tissue necrosis in STEMI patients. Drug treatment to ACS patients for a short-term period (4-6 days) elicited no significant improvement in their AOA. However, ACS patients receiving longterm drug treatment (4-5 weeks) exhibited a significant increase in AOA as well as an improvement in the clinical status. Conclusion: This preliminary study supports the role of oxidative stress in the pathogenesis of ACS and the use of salivary and serum AOA as a potential marker of the redox status and disease severity.
format	Article
author	Gulati, Yogesh Narain, Varun Shanker Saxena, Anil Kumar Nigam, PK Ali, Bashir
author_facet	Gulati, Yogesh Narain, Varun Shanker Saxena, Anil Kumar Nigam, PK Ali, Bashir
author_sort	Gulati, Yogesh
title	Salivary and serum antioxidant activity in patients with acute coronary syndrome
title_short	Salivary and serum antioxidant activity in patients with acute coronary syndrome
title_full	Salivary and serum antioxidant activity in patients with acute coronary syndrome
title_fullStr	Salivary and serum antioxidant activity in patients with acute coronary syndrome
title_full_unstemmed	Salivary and serum antioxidant activity in patients with acute coronary syndrome
title_sort	salivary and serum antioxidant activity in patients with acute coronary syndrome
publisher	Faculty of Medicine, International Islamic University Malaysia
publishDate	2012
url	http://irep.iium.edu.my/27277/ http://irep.iium.edu.my/27277/ http://irep.iium.edu.my/27277/1/Publication_IMJM_2012.pdf
first_indexed	2023-09-18T20:40:34Z
last_indexed	2023-09-18T20:40:34Z
_version_	1777409337210175488

Salivary and serum antioxidant activity in patients with acute coronary syndrome

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