The Association Between Sleep Apnea and Young Adults With Hypertension

Objectives/Hypothesis: To study the association between sleep apnea and hypertension in a younger age group than previously studied, adding upper airway sizes at endoscopy as important compounding variables not often included in the past. Study Design: Case control. Methods: We analyzed data on...

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Main Authors:	Asha'ari, Zamzil Amin, Hasmoni, Mohamed Hadzri, Ab Rahman, Jamalludin, Yusof, Rosnida Azura, Raja Lope Ahmad, Raja Ahmad Al'konee
Format:	Article
Language:	English
Published:	The American Laryngological, Rhinological, and Otological Society, Inc. and John Wiley & sons, 2012
Subjects:	RF Otorhinolaryngology
Online Access:	http://irep.iium.edu.my/25851/ http://irep.iium.edu.my/25851/ http://irep.iium.edu.my/25851/ http://irep.iium.edu.my/25851/1/LARYNGOSCOPE_OSAHPTN.pdf

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spelling	iium-258512016-03-10T02:15:27Z http://irep.iium.edu.my/25851/ The Association Between Sleep Apnea and Young Adults With Hypertension Asha'ari, Zamzil Amin Hasmoni, Mohamed Hadzri Ab Rahman, Jamalludin Yusof, Rosnida Azura Raja Lope Ahmad, Raja Ahmad Al'konee RF Otorhinolaryngology Objectives/Hypothesis: To study the association between sleep apnea and hypertension in a younger age group than previously studied, adding upper airway sizes at endoscopy as important compounding variables not often included in the past. Study Design: Case control. Methods: We analyzed data on sleep-disordered breathing (based on polysomnography tests), body mass index (BMI), neck circumference, upper airway endoscopy sizes, and habitus and health history in 120 hypertensive and 120 nonhypertensive participants in a clinic-based setting. Independent t test, v2, multivariate analysis, and binary logistic regression models were used for case-control comparison. Results: The mean age of the participants was 27 years; 67.5% were male. The incidence and severity of sleep apnea were significantly higher in the hypertensive than the control subjects. Persons with hypertension had an OR of 2.7 times of having comorbid sleep apnea than patients without hypertension (95% confidence interval [CI] 1.2-6.1). Persons with sleep apnea (AHI [apnea-hypopnea index] �5) had an OR of 2.76 (95% CI 1.57-4.86), and persons with severe sleep apnea (AHI �30) had an OR 7.94 (95% CI 4.21-15.33) for having hypertension than did persons without sleep apnea. Although adjustments for the compounding factors, particularly BMI, decreased the OR to a large degree, subjects with severe sleep apnea were still 72% more likely to have hypertension than subjects without sleep apnea. Conclusions: Sleep apnea is related to hypertension in young adults aged 18 to 40 years. The association was more pronounced with the increasing severity of sleep apnea. Screening for sleep apnea should be considered in young adults with hypertension. The American Laryngological, Rhinological, and Otological Society, Inc. and John Wiley & sons, 2012-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/25851/1/LARYNGOSCOPE_OSAHPTN.pdf Asha'ari, Zamzil Amin and Hasmoni, Mohamed Hadzri and Ab Rahman, Jamalludin and Yusof, Rosnida Azura and Raja Lope Ahmad, Raja Ahmad Al'konee (2012) The Association Between Sleep Apnea and Young Adults With Hypertension. Laryngoscope, 122 (10). pp. 2337-2342. ISSN 1531-4995 http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291531-4995 10.1002/lary.23379
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RF Otorhinolaryngology
spellingShingle	RF Otorhinolaryngology Asha'ari, Zamzil Amin Hasmoni, Mohamed Hadzri Ab Rahman, Jamalludin Yusof, Rosnida Azura Raja Lope Ahmad, Raja Ahmad Al'konee The Association Between Sleep Apnea and Young Adults With Hypertension
description	Objectives/Hypothesis: To study the association between sleep apnea and hypertension in a younger age group than previously studied, adding upper airway sizes at endoscopy as important compounding variables not often included in the past. Study Design: Case control. Methods: We analyzed data on sleep-disordered breathing (based on polysomnography tests), body mass index (BMI), neck circumference, upper airway endoscopy sizes, and habitus and health history in 120 hypertensive and 120 nonhypertensive participants in a clinic-based setting. Independent t test, v2, multivariate analysis, and binary logistic regression models were used for case-control comparison. Results: The mean age of the participants was 27 years; 67.5% were male. The incidence and severity of sleep apnea were significantly higher in the hypertensive than the control subjects. Persons with hypertension had an OR of 2.7 times of having comorbid sleep apnea than patients without hypertension (95% confidence interval [CI] 1.2-6.1). Persons with sleep apnea (AHI [apnea-hypopnea index] �5) had an OR of 2.76 (95% CI 1.57-4.86), and persons with severe sleep apnea (AHI �30) had an OR 7.94 (95% CI 4.21-15.33) for having hypertension than did persons without sleep apnea. Although adjustments for the compounding factors, particularly BMI, decreased the OR to a large degree, subjects with severe sleep apnea were still 72% more likely to have hypertension than subjects without sleep apnea. Conclusions: Sleep apnea is related to hypertension in young adults aged 18 to 40 years. The association was more pronounced with the increasing severity of sleep apnea. Screening for sleep apnea should be considered in young adults with hypertension.
format	Article
author	Asha'ari, Zamzil Amin Hasmoni, Mohamed Hadzri Ab Rahman, Jamalludin Yusof, Rosnida Azura Raja Lope Ahmad, Raja Ahmad Al'konee
author_facet	Asha'ari, Zamzil Amin Hasmoni, Mohamed Hadzri Ab Rahman, Jamalludin Yusof, Rosnida Azura Raja Lope Ahmad, Raja Ahmad Al'konee
author_sort	Asha'ari, Zamzil Amin
title	The Association Between Sleep Apnea and Young Adults With Hypertension
title_short	The Association Between Sleep Apnea and Young Adults With Hypertension
title_full	The Association Between Sleep Apnea and Young Adults With Hypertension
title_fullStr	The Association Between Sleep Apnea and Young Adults With Hypertension
title_full_unstemmed	The Association Between Sleep Apnea and Young Adults With Hypertension
title_sort	association between sleep apnea and young adults with hypertension
publisher	The American Laryngological, Rhinological, and Otological Society, Inc. and John Wiley & sons,
publishDate	2012
url	http://irep.iium.edu.my/25851/ http://irep.iium.edu.my/25851/ http://irep.iium.edu.my/25851/ http://irep.iium.edu.my/25851/1/LARYNGOSCOPE_OSAHPTN.pdf
first_indexed	2023-09-18T20:38:32Z
last_indexed	2023-09-18T20:38:32Z
_version_	1777409209181143040

The Association Between Sleep Apnea and Young Adults With Hypertension

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