The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.

Our previous study showed that crude extract of Pluchea Indica was able to lower blood glucose levels in hypoglycaemic test on normal rats. This study is an attempt to demonstrate whether the effect was directly related to the effect on the insulin release by the pancreatic B cell. The B cell line o...

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Main Authors:	Kasmuri, Abdul Razak, Bakhtiar, M. Taher, Suriyah, Wastuti
Format:	Conference or Workshop Item
Language:	English
Published:	2012
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://irep.iium.edu.my/25301/ http://irep.iium.edu.my/25301/ http://irep.iium.edu.my/25301/1/P068.pdf

id	iium-25301
recordtype	eprints
spelling	iium-253012014-12-09T01:12:40Z http://irep.iium.edu.my/25301/ The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line. Kasmuri, Abdul Razak Bakhtiar, M. Taher Suriyah, Wastuti R Medicine (General) RB Pathology Our previous study showed that crude extract of Pluchea Indica was able to lower blood glucose levels in hypoglycaemic test on normal rats. This study is an attempt to demonstrate whether the effect was directly related to the effect on the insulin release by the pancreatic B cell. The B cell line of RIN5f of rats insulinamo were used in studying the insulin-releasing effect of sequential extractions of Pluchea Indica. The solvents used in the extraction were in the sequence of hexane, dichloromethane, ethyl acetate and methanol. Beside the sequential extractions there was a water extract of the plant. An antidiabetic drug, glibenclamide, which is known to stimulate B cells to produce insulin, was used as the positive control. The results showed that glibenclamide-treated, hexane, dichloromethane and water extract-treated groups were significantly increased the insulin release (p<0.01 and p<0.05 for all extract-treated groups). Thus the study showed that the model was able to demonstrate the stimulating effect of glibenclamide and show the effect of the plant extracts on B cells. 2012 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/25301/1/P068.pdf Kasmuri, Abdul Razak and Bakhtiar, M. Taher and Suriyah, Wastuti (2012) The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line. In: 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology, 18-20 may 2012, Equatorial Hotel, Penang. http://www.mspp2012.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Kasmuri, Abdul Razak Bakhtiar, M. Taher Suriyah, Wastuti The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
description	Our previous study showed that crude extract of Pluchea Indica was able to lower blood glucose levels in hypoglycaemic test on normal rats. This study is an attempt to demonstrate whether the effect was directly related to the effect on the insulin release by the pancreatic B cell. The B cell line of RIN5f of rats insulinamo were used in studying the insulin-releasing effect of sequential extractions of Pluchea Indica. The solvents used in the extraction were in the sequence of hexane, dichloromethane, ethyl acetate and methanol. Beside the sequential extractions there was a water extract of the plant. An antidiabetic drug, glibenclamide, which is known to stimulate B cells to produce insulin, was used as the positive control. The results showed that glibenclamide-treated, hexane, dichloromethane and water extract-treated groups were significantly increased the insulin release (p<0.01 and p<0.05 for all extract-treated groups). Thus the study showed that the model was able to demonstrate the stimulating effect of glibenclamide and show the effect of the plant extracts on B cells.
format	Conference or Workshop Item
author	Kasmuri, Abdul Razak Bakhtiar, M. Taher Suriyah, Wastuti
author_facet	Kasmuri, Abdul Razak Bakhtiar, M. Taher Suriyah, Wastuti
author_sort	Kasmuri, Abdul Razak
title	The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_short	The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_full	The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_fullStr	The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_full_unstemmed	The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.
title_sort	effect of pluchea indica (l) (beluntas) extracts on the insulin release of rin5f cell line.
publishDate	2012
url	http://irep.iium.edu.my/25301/ http://irep.iium.edu.my/25301/ http://irep.iium.edu.my/25301/1/P068.pdf
first_indexed	2023-09-18T20:37:46Z
last_indexed	2023-09-18T20:37:46Z
_version_	1777409160736931840

The effect of Pluchea Indica (L) (Beluntas) extracts on the insulin release of RIN5F cell line.

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