Fowl cholera vaccine production: process optimization in laboratory scale fermenter

The process optimization of Pasteurella multocida fermentation for fowl cholera vaccine production in 2L laboratory scale fermenter was successfully carried out in stirred tank reactor (STR). This study focuses on the maximizing the cell growth and protein production of P. multocida by optimizing p...

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Main Authors:	Mel, Maizirwan, Abdul Karim, Mohamed Ismail, Yob, Nor Jannah, Samsury, Intan Zahrah, Syed Hassan, Sharifah, Ngah Hamid, Akma
Format:	Book Chapter
Language:	English
Published:	IIUM Press 2011
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/25081/ http://irep.iium.edu.my/25081/ http://irep.iium.edu.my/25081/3/CurrentResearch_19.pdf

id	iium-25081
recordtype	eprints
spelling	iium-250812012-07-24T05:17:53Z http://irep.iium.edu.my/25081/ Fowl cholera vaccine production: process optimization in laboratory scale fermenter Mel, Maizirwan Abdul Karim, Mohamed Ismail Yob, Nor Jannah Samsury, Intan Zahrah Syed Hassan, Sharifah Ngah Hamid, Akma TP248.13 Biotechnology The process optimization of Pasteurella multocida fermentation for fowl cholera vaccine production in 2L laboratory scale fermenter was successfully carried out in stirred tank reactor (STR). This study focuses on the maximizing the cell growth and protein production of P. multocida by optimizing process of various fermentation condition. The process optimization was designed for different level of parameters that were dissolved oxygen concentration (pO2), stirred speed (rpm)and pH using Taguchi's Experimental Robust Design by STATISTICA 6.0 agitation (200 rpm) and for antigen protein production was significantly affected by higher level (1 vvm). The correlation between the parameters was very affecting the productivity of the vaccine produced. IIUM Press 2011 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/25081/3/CurrentResearch_19.pdf Mel, Maizirwan and Abdul Karim, Mohamed Ismail and Yob, Nor Jannah and Samsury, Intan Zahrah and Syed Hassan, Sharifah and Ngah Hamid, Akma (2011) Fowl cholera vaccine production: process optimization in laboratory scale fermenter. In: Current research and development in biotechnology engineering at IIUM (Volume III). IIUM Press, Kuala Lumpur, pp. 147-158. ISBN 9789674181444 http://rms.research.iium.edu.my/bookstore/default.aspx
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Mel, Maizirwan Abdul Karim, Mohamed Ismail Yob, Nor Jannah Samsury, Intan Zahrah Syed Hassan, Sharifah Ngah Hamid, Akma Fowl cholera vaccine production: process optimization in laboratory scale fermenter
description	The process optimization of Pasteurella multocida fermentation for fowl cholera vaccine production in 2L laboratory scale fermenter was successfully carried out in stirred tank reactor (STR). This study focuses on the maximizing the cell growth and protein production of P. multocida by optimizing process of various fermentation condition. The process optimization was designed for different level of parameters that were dissolved oxygen concentration (pO2), stirred speed (rpm)and pH using Taguchi's Experimental Robust Design by STATISTICA 6.0 agitation (200 rpm) and for antigen protein production was significantly affected by higher level (1 vvm). The correlation between the parameters was very affecting the productivity of the vaccine produced.
format	Book Chapter
author	Mel, Maizirwan Abdul Karim, Mohamed Ismail Yob, Nor Jannah Samsury, Intan Zahrah Syed Hassan, Sharifah Ngah Hamid, Akma
author_facet	Mel, Maizirwan Abdul Karim, Mohamed Ismail Yob, Nor Jannah Samsury, Intan Zahrah Syed Hassan, Sharifah Ngah Hamid, Akma
author_sort	Mel, Maizirwan
title	Fowl cholera vaccine production: process optimization in laboratory scale fermenter
title_short	Fowl cholera vaccine production: process optimization in laboratory scale fermenter
title_full	Fowl cholera vaccine production: process optimization in laboratory scale fermenter
title_fullStr	Fowl cholera vaccine production: process optimization in laboratory scale fermenter
title_full_unstemmed	Fowl cholera vaccine production: process optimization in laboratory scale fermenter
title_sort	fowl cholera vaccine production: process optimization in laboratory scale fermenter
publisher	IIUM Press
publishDate	2011
url	http://irep.iium.edu.my/25081/ http://irep.iium.edu.my/25081/ http://irep.iium.edu.my/25081/3/CurrentResearch_19.pdf
first_indexed	2023-09-18T20:37:28Z
last_indexed	2023-09-18T20:37:28Z
_version_	1777409141894021120

Fowl cholera vaccine production: process optimization in laboratory scale fermenter

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