Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn)

BACKGROUND: Osteoarthritis is a debilitating degenerative disease of the old age . One of the pathophysiology is that the synovial fluids (SF) are reduced due to the lowered concentration, reduced molecular weight of hyaluronic acid, thus reducing the viscoelasticity of the SF. Apart from the pharma...

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Main Authors:	Abd. Rahim, Nour El Huda, Zulkifly, Ahmad Hafiz, Mohamed, Farahidah, Ku Zaifah, Norsidah
Format:	Article
Language:	English
Published:	Malaysian Medical Associations 2012
Subjects:	RD701 Orthopedics RM Therapeutics. Pharmacology TA164 Bioengineering
Online Access:	http://irep.iium.edu.my/24781/ http://irep.iium.edu.my/24781/ http://irep.iium.edu.my/24781/1/Viscosity_and_Viscoelasticity_of_Osteoarthritic.pdf

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recordtype	eprints
spelling	iium-247812015-04-07T03:21:01Z http://irep.iium.edu.my/24781/ Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn) Abd. Rahim, Nour El Huda Zulkifly, Ahmad Hafiz Mohamed, Farahidah Ku Zaifah, Norsidah RD701 Orthopedics RM Therapeutics. Pharmacology TA164 Bioengineering BACKGROUND: Osteoarthritis is a debilitating degenerative disease of the old age . One of the pathophysiology is that the synovial fluids (SF) are reduced due to the lowered concentration, reduced molecular weight of hyaluronic acid, thus reducing the viscoelasticity of the SF. Apart from the pharmacological treatments, intraarticular injection of hyaluronic acid (IAHA) was introduced as a viscosupplement in osteoarthritic patients to restore the viscoelasticity of the synovial fluids, give symptomatic relief of joint pain and delay the total joint arthroplasty. OBJECTIVE: To evaluate the viscosity and viscoelasticity of osteoarthritic SF with the aim to compare with IAHA; Synvisc (high molecular weight IAHA) and Suplasyn (low molecular weight IAHA). MATERIALS AND METHOD: The osteoarthritic SF was obtained from consented patients undergone total knee arthroplasty. The viscosity and the viscoelasticity of IAHA and osteoarthritic SF were analyzed at different temperatures (25, 37 and 40°C) using ThermoHaake rheometer. RESULTS: The flow curves constructed showed that osteoarthritic SF and both IAHA exhibited non-Newtonian shear thinning (pseudoplastic) fluid behaviour. The osteoarthritic SF had the lowest viscosity compared to IAHA. By increasing the temperatures, the viscosity of the IAHA and osteoarthritic SF were reduced. In the viscoelasticity test, the storage/elastic modulus of osteoarthritic SF and Synvisc were more dominant than the loss/viscous modulus. Unlike Suplasyn, the viscous modulus was more pronounced than the elastic modulus in all temperatures. CONCLUSION: At human body temperature, 37°C, both viscosupplements and osteoarthritic synovial fluids shared the same pseudoplastic type of non-Newtonian fluid. Synvisc and osteoarthritic SF showed elastic like behaviour more prominent than the viscous like behaviour opposite to Suplasyn. The rheological behaviour of Suplasyn and Synvisc with osteoarthritic SF were different because of the differences between the molecular weight of the hyaluronic acid and the network forming ability. Malaysian Medical Associations 2012-06-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/24781/1/Viscosity_and_Viscoelasticity_of_Osteoarthritic.pdf Abd. Rahim, Nour El Huda and Zulkifly, Ahmad Hafiz and Mohamed, Farahidah and Ku Zaifah, Norsidah (2012) Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn). Malaysian Orthopaedic Journal, 6 (2sup.A). p. 75. ISSN 1985-2533 http://www.morthoj.org/supplements/v6-sA/index.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RD701 Orthopedics RM Therapeutics. Pharmacology TA164 Bioengineering
spellingShingle	RD701 Orthopedics RM Therapeutics. Pharmacology TA164 Bioengineering Abd. Rahim, Nour El Huda Zulkifly, Ahmad Hafiz Mohamed, Farahidah Ku Zaifah, Norsidah Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn)
description	BACKGROUND: Osteoarthritis is a debilitating degenerative disease of the old age . One of the pathophysiology is that the synovial fluids (SF) are reduced due to the lowered concentration, reduced molecular weight of hyaluronic acid, thus reducing the viscoelasticity of the SF. Apart from the pharmacological treatments, intraarticular injection of hyaluronic acid (IAHA) was introduced as a viscosupplement in osteoarthritic patients to restore the viscoelasticity of the synovial fluids, give symptomatic relief of joint pain and delay the total joint arthroplasty. OBJECTIVE: To evaluate the viscosity and viscoelasticity of osteoarthritic SF with the aim to compare with IAHA; Synvisc (high molecular weight IAHA) and Suplasyn (low molecular weight IAHA). MATERIALS AND METHOD: The osteoarthritic SF was obtained from consented patients undergone total knee arthroplasty. The viscosity and the viscoelasticity of IAHA and osteoarthritic SF were analyzed at different temperatures (25, 37 and 40°C) using ThermoHaake rheometer. RESULTS: The flow curves constructed showed that osteoarthritic SF and both IAHA exhibited non-Newtonian shear thinning (pseudoplastic) fluid behaviour. The osteoarthritic SF had the lowest viscosity compared to IAHA. By increasing the temperatures, the viscosity of the IAHA and osteoarthritic SF were reduced. In the viscoelasticity test, the storage/elastic modulus of osteoarthritic SF and Synvisc were more dominant than the loss/viscous modulus. Unlike Suplasyn, the viscous modulus was more pronounced than the elastic modulus in all temperatures. CONCLUSION: At human body temperature, 37°C, both viscosupplements and osteoarthritic synovial fluids shared the same pseudoplastic type of non-Newtonian fluid. Synvisc and osteoarthritic SF showed elastic like behaviour more prominent than the viscous like behaviour opposite to Suplasyn. The rheological behaviour of Suplasyn and Synvisc with osteoarthritic SF were different because of the differences between the molecular weight of the hyaluronic acid and the network forming ability.
format	Article
author	Abd. Rahim, Nour El Huda Zulkifly, Ahmad Hafiz Mohamed, Farahidah Ku Zaifah, Norsidah
author_facet	Abd. Rahim, Nour El Huda Zulkifly, Ahmad Hafiz Mohamed, Farahidah Ku Zaifah, Norsidah
author_sort	Abd. Rahim, Nour El Huda
title	Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn)
title_short	Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn)
title_full	Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn)
title_fullStr	Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn)
title_full_unstemmed	Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn)
title_sort	viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (synvisc and suplasyn)
publisher	Malaysian Medical Associations
publishDate	2012
url	http://irep.iium.edu.my/24781/ http://irep.iium.edu.my/24781/ http://irep.iium.edu.my/24781/1/Viscosity_and_Viscoelasticity_of_Osteoarthritic.pdf
first_indexed	2023-09-18T20:37:04Z
last_indexed	2023-09-18T20:37:04Z
_version_	1777409116814180352

Viscosity and viscoelasticity of osteoarthritic synovial fluids in comparison to intraarticular injection of hyaluronic acid (Synvisc and Suplasyn)

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