Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia

Background and Objectives: Despite much medical progress, stroke remains a leading cause of death and disability. The aim of our study was to analyze the frequency of various risk factors and determine predictors of in-hospital mortality among primary intracerebral hemorrhage (PICH) patients, thus...

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Main Authors:	Rathor, Mohammad Yousuf, Abdul Rani, Mohammed Fauzi, Ab Rahman, Jamalludin, How, Soon Hin, Abdul Rashid, Mohd Amran, Che Abdullah, Shahrin Tarmizi, Omar, Ahmad Marzuki, Shah, Anis
Format:	Article
Language:	English
Published:	Neurology Asia 2012
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/24622/ http://irep.iium.edu.my/24622/ http://irep.iium.edu.my/24622/1/Predictors_of_in-hospital_mortality_in_primary.pdf

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spelling	iium-246222016-03-10T02:16:56Z http://irep.iium.edu.my/24622/ Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia Rathor, Mohammad Yousuf Abdul Rani, Mohammed Fauzi Ab Rahman, Jamalludin How, Soon Hin Abdul Rashid, Mohd Amran Che Abdullah, Shahrin Tarmizi Omar, Ahmad Marzuki Shah, Anis R Medicine (General) Background and Objectives: Despite much medical progress, stroke remains a leading cause of death and disability. The aim of our study was to analyze the frequency of various risk factors and determine predictors of in-hospital mortality among primary intracerebral hemorrhage (PICH) patients, thus providing insight in developing therapeutic strategies to improve the outcome. Methods: A prospective study conducted at a tertiary care hospital. Results: A total of 160 patients (108 male and 52 female) were evaluated. Their ages ranged from 25 to 85 years (mean age was 58.3 ± 11.4 years). Hypertension was the commonest risk factor (74.4%), followed by diabetes mellitus (18.8%) and cigarette smoking (36.3%). The commonest location of ICH was lobar (43.8%) followed by basal ganglia / internal capsule (28.1 %) and multilobar (13.1%). The overall in-hospital mortality was 32.5 %. About one third (32.7%) of the deaths occurred within fi rst 24 hours, this rose to 38.5% within fi rst 2 days and 84.6% within one week. The signifi cant independent predictors of acute in- hospital mortality were Glasgow Coma Scale (GCS) on admission, posterior fossa bleed (OR 11.01; 95% CI 3.21 to 37.81), hematoma volume >60ml (OR 4.72; 95% CI 1.34 to 16.64), mid line shift (OR 3.32; 95% CI 1.05 to 10.50) and intraventricular extension of haemorrhage (OR 5.69; 95% CI 2.24 to 14.47). Conclusion: Low GCS score, posterior fossa bleed, and large hematoma volume were main indicators of mortality following PICH in East coast of Peninsular Malaysia. Neurology Asia 2012-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/24622/1/Predictors_of_in-hospital_mortality_in_primary.pdf Rathor, Mohammad Yousuf and Abdul Rani, Mohammed Fauzi and Ab Rahman, Jamalludin and How, Soon Hin and Abdul Rashid, Mohd Amran and Che Abdullah, Shahrin Tarmizi and Omar, Ahmad Marzuki and Shah, Anis (2012) Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia. Neurology Asia, 17 (2). pp. 93-99. ISSN 1823-6138 http://www.neurology-asia.org/articles/neuroasia-2012-17(2)-093.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Rathor, Mohammad Yousuf Abdul Rani, Mohammed Fauzi Ab Rahman, Jamalludin How, Soon Hin Abdul Rashid, Mohd Amran Che Abdullah, Shahrin Tarmizi Omar, Ahmad Marzuki Shah, Anis Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia
description	Background and Objectives: Despite much medical progress, stroke remains a leading cause of death and disability. The aim of our study was to analyze the frequency of various risk factors and determine predictors of in-hospital mortality among primary intracerebral hemorrhage (PICH) patients, thus providing insight in developing therapeutic strategies to improve the outcome. Methods: A prospective study conducted at a tertiary care hospital. Results: A total of 160 patients (108 male and 52 female) were evaluated. Their ages ranged from 25 to 85 years (mean age was 58.3 ± 11.4 years). Hypertension was the commonest risk factor (74.4%), followed by diabetes mellitus (18.8%) and cigarette smoking (36.3%). The commonest location of ICH was lobar (43.8%) followed by basal ganglia / internal capsule (28.1 %) and multilobar (13.1%). The overall in-hospital mortality was 32.5 %. About one third (32.7%) of the deaths occurred within fi rst 24 hours, this rose to 38.5% within fi rst 2 days and 84.6% within one week. The signifi cant independent predictors of acute in- hospital mortality were Glasgow Coma Scale (GCS) on admission, posterior fossa bleed (OR 11.01; 95% CI 3.21 to 37.81), hematoma volume >60ml (OR 4.72; 95% CI 1.34 to 16.64), mid line shift (OR 3.32; 95% CI 1.05 to 10.50) and intraventricular extension of haemorrhage (OR 5.69; 95% CI 2.24 to 14.47). Conclusion: Low GCS score, posterior fossa bleed, and large hematoma volume were main indicators of mortality following PICH in East coast of Peninsular Malaysia.
format	Article
author	Rathor, Mohammad Yousuf Abdul Rani, Mohammed Fauzi Ab Rahman, Jamalludin How, Soon Hin Abdul Rashid, Mohd Amran Che Abdullah, Shahrin Tarmizi Omar, Ahmad Marzuki Shah, Anis
author_facet	Rathor, Mohammad Yousuf Abdul Rani, Mohammed Fauzi Ab Rahman, Jamalludin How, Soon Hin Abdul Rashid, Mohd Amran Che Abdullah, Shahrin Tarmizi Omar, Ahmad Marzuki Shah, Anis
author_sort	Rathor, Mohammad Yousuf
title	Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia
title_short	Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia
title_full	Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia
title_fullStr	Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia
title_full_unstemmed	Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia
title_sort	predictors of in-hospital mortality in primary intracerebral haemorrhage in east coast of peninsular malaysia
publisher	Neurology Asia
publishDate	2012
url	http://irep.iium.edu.my/24622/ http://irep.iium.edu.my/24622/ http://irep.iium.edu.my/24622/1/Predictors_of_in-hospital_mortality_in_primary.pdf
first_indexed	2023-09-18T20:36:54Z
last_indexed	2023-09-18T20:36:54Z
_version_	1777409106813911040

Predictors of in-hospital mortality in primary intracerebral haemorrhage in East coast of Peninsular Malaysia

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