Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient

Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient

Langerhans cell histiocytosis of the spine frequently presents as a solitary lesion and rarely results in neurological deficit. Involvement of thyroid tissue is also rare, even in multifocal disease presentations. We present an unusual variant of Langerhans cell histiocytosis in a 37-year-old man pr...

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Bibliographic Details
Main Authors: Sharifudin, Mohd Ariff, Johari, Joehaimey, Omar, Ahmad Sabri, Wan, Zulmi
Format: Article
Language:English
Published: Malaysian Orthopaedic Association (MOA) 2011
Subjects:
RD701 Orthopedics
Online Access:http://irep.iium.edu.my/24412/
http://irep.iium.edu.my/24412/
http://irep.iium.edu.my/24412/
http://irep.iium.edu.my/24412/1/Langerhans_Cell_Histiocytosis.pdf
id iium-24412
recordtype eprints
spelling iium-244122013-01-15T14:44:32Z http://irep.iium.edu.my/24412/ Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient Sharifudin, Mohd Ariff Johari, Joehaimey Omar, Ahmad Sabri Wan, Zulmi RD701 Orthopedics Langerhans cell histiocytosis of the spine frequently presents as a solitary lesion and rarely results in neurological deficit. Involvement of thyroid tissue is also rare, even in multifocal disease presentations. We present an unusual variant of Langerhans cell histiocytosis in a 37-year-old man presenting with profound quadriparesis and incidental thyroid involvement. MR imaging and skeletal radiographs revealed widespread involvement of the spine. The patient underwent surgical resection of the tumour and stabilization of the spine. Diagnosis was confirmed by histological and immunohistochemistry analysis. Langerhans cell histiocytosis should be included in the differential diagnosis of radiolucent lesions of the spine in adults. Malaysian Orthopaedic Association (MOA) 2011-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/24412/1/Langerhans_Cell_Histiocytosis.pdf Sharifudin, Mohd Ariff and Johari, Joehaimey and Omar, Ahmad Sabri and Wan, Zulmi (2011) Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient. Malaysian Orthopaedic Journal, 5 (3). pp. 28-31. ISSN 1985-2533 http://www.morthoj.org/2011v5n3/Langerhans_Cell_Histiocytosis.pdf 10.5704/MOJ/1111.004
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RD701 Orthopedics
spellingShingle RD701 Orthopedics
Sharifudin, Mohd Ariff
Johari, Joehaimey
Omar, Ahmad Sabri
Wan, Zulmi
Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient
description Langerhans cell histiocytosis of the spine frequently presents as a solitary lesion and rarely results in neurological deficit. Involvement of thyroid tissue is also rare, even in multifocal disease presentations. We present an unusual variant of Langerhans cell histiocytosis in a 37-year-old man presenting with profound quadriparesis and incidental thyroid involvement. MR imaging and skeletal radiographs revealed widespread involvement of the spine. The patient underwent surgical resection of the tumour and stabilization of the spine. Diagnosis was confirmed by histological and immunohistochemistry analysis. Langerhans cell histiocytosis should be included in the differential diagnosis of radiolucent lesions of the spine in adults.
format Article
author Sharifudin, Mohd Ariff
Johari, Joehaimey
Omar, Ahmad Sabri
Wan, Zulmi
author_facet Sharifudin, Mohd Ariff
Johari, Joehaimey
Omar, Ahmad Sabri
Wan, Zulmi
author_sort Sharifudin, Mohd Ariff
title Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient
title_short Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient
title_full Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient
title_fullStr Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient
title_full_unstemmed Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient
title_sort langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient
publisher Malaysian Orthopaedic Association (MOA)
publishDate 2011
url http://irep.iium.edu.my/24412/
http://irep.iium.edu.my/24412/
http://irep.iium.edu.my/24412/
http://irep.iium.edu.my/24412/1/Langerhans_Cell_Histiocytosis.pdf
first_indexed 2023-09-18T20:36:35Z
last_indexed 2023-09-18T20:36:35Z
_version_ 1777409086653988864

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