Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors

ABSTRACT The chapter focuses on the growth kinetics and modelling of recombinant Escherichia coli in fermentation processes. Experimental data for from four bioreactors were analyzed using Monod, Logistic and Contois models. A comparison between the models' predicted values of cell, substrat...

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Main Authors:	Ibrahim Ali , Noorbatcha, Wan Norulhazrina, Wan Hassan, Maizirwan , Mel
Format:	Book Chapter
Language:	English
Published:	IIUM Press 2011
Subjects:	TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/24222/ http://irep.iium.edu.my/24222/ http://irep.iium.edu.my/24222/3/Modeling_the_Growth.pdf

id	iium-24222
recordtype	eprints
spelling	iium-242222012-08-07T06:21:56Z http://irep.iium.edu.my/24222/ Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors Ibrahim Ali , Noorbatcha Wan Norulhazrina, Wan Hassan Maizirwan , Mel TP248.13 Biotechnology ABSTRACT The chapter focuses on the growth kinetics and modelling of recombinant Escherichia coli in fermentation processes. Experimental data for from four bioreactors were analyzed using Monod, Logistic and Contois models. A comparison between the models' predicted values of cell, substrate and product (β-glucuronidase enzyme) was done with the kinetic parameters mmax, YX/S, Ks, k1, and k2 calculated from the experimental data. Substrate used for this modelling was glucose while the independent variables were peptone soy, sodium chloride and yeast extract. The Logistic model is found to describe the growth of E. coli in the fermentation process with the limited supply of glucose and the Monod and Contois models failed to represent the cell growth profiles. Keywords: growth kinetics, modeling, recombinant E. coli, fermentation. IIUM Press 2011 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/24222/3/Modeling_the_Growth.pdf Ibrahim Ali , Noorbatcha and Wan Norulhazrina, Wan Hassan and Maizirwan , Mel (2011) Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors. In: Bioprocessing of Recombinant E. Coli producing beta-glucuronidase enzyme. IIUM Press, Kuala Lumpur, Malaysia, pp. 115-123. ISBN 9789674180102 http://rms.research.iium.edu.my/bookstore/default.aspx
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TP248.13 Biotechnology
spellingShingle	TP248.13 Biotechnology Ibrahim Ali , Noorbatcha Wan Norulhazrina, Wan Hassan Maizirwan , Mel Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors
description	ABSTRACT The chapter focuses on the growth kinetics and modelling of recombinant Escherichia coli in fermentation processes. Experimental data for from four bioreactors were analyzed using Monod, Logistic and Contois models. A comparison between the models' predicted values of cell, substrate and product (β-glucuronidase enzyme) was done with the kinetic parameters mmax, YX/S, Ks, k1, and k2 calculated from the experimental data. Substrate used for this modelling was glucose while the independent variables were peptone soy, sodium chloride and yeast extract. The Logistic model is found to describe the growth of E. coli in the fermentation process with the limited supply of glucose and the Monod and Contois models failed to represent the cell growth profiles. Keywords: growth kinetics, modeling, recombinant E. coli, fermentation.
format	Book Chapter
author	Ibrahim Ali , Noorbatcha Wan Norulhazrina, Wan Hassan Maizirwan , Mel
author_facet	Ibrahim Ali , Noorbatcha Wan Norulhazrina, Wan Hassan Maizirwan , Mel
author_sort	Ibrahim Ali , Noorbatcha
title	Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors
title_short	Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors
title_full	Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors
title_fullStr	Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors
title_full_unstemmed	Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors
title_sort	modeling the growth kinetics of escherichia coli fermentation in bioreactors
publisher	IIUM Press
publishDate	2011
url	http://irep.iium.edu.my/24222/ http://irep.iium.edu.my/24222/ http://irep.iium.edu.my/24222/3/Modeling_the_Growth.pdf
first_indexed	2023-09-18T20:36:23Z
last_indexed	2023-09-18T20:36:23Z
_version_	1777409073949442048

Modeling the growth kinetics of Escherichia Coli fermentation in bioreactors

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