Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis

Background and Objective: Data on whether periodontal therapy affects serum CRP levels are inconclusive. The aim of this study was to determine if nonsurgical periodontal therapy has any effect on CRP and serum lipid levels in patients with advanced periodontitis. Material and Methods: Thirty-si...

Full description

Bibliographic Details
Main Authors:	Kamil, Wisam Alaa, Habashnah, Rola, Khader, Yousef, Hilal Abbood Al-Bayati, Lina, Taani, D.
Format:	Article
Language:	English
Published:	John Wiley & Sons 2011
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/23537/ http://irep.iium.edu.my/23537/ http://irep.iium.edu.my/23537/ http://irep.iium.edu.my/23537/1/Effects_of_nonsurgical.pdf

id	iium-23537
recordtype	eprints
spelling	iium-235372013-06-27T04:33:23Z http://irep.iium.edu.my/23537/ Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis Kamil, Wisam Alaa Habashnah, Rola Khader, Yousef Hilal Abbood Al-Bayati, Lina Taani, D. RK Dentistry Background and Objective: Data on whether periodontal therapy affects serum CRP levels are inconclusive. The aim of this study was to determine if nonsurgical periodontal therapy has any effect on CRP and serum lipid levels in patients with advanced periodontitis. Material and Methods: Thirty-six systemically healthy patients, ‡ 40 years of age and with advanced periodontitis, were recruited for the study. Patients were randomized consecutively to one of two groups: the treatment group (n = 18) or the control group (n = 18). Treated subjects received nonsurgical periodontal therapy, which included oral hygiene instructions and subgingival scaling and root planing. Systemic levels of inflammatory markers [C-reactive protein (CRP) and the lipid profile] were measured at baseline and 3 mo after periodontal therapy. Results: Nonsurgical periodontal therapy in the treatment group resulted in a significant reduction in the serum CRP level. The average CRP level decreased from 2.3 mg/dL at baseline to 1.8 mg/dL (p < 0.005) after 3 mo of periodontal therapy. The average reduction (95% confidence interval) in CRP was 0.498 (95% confidence interval = 0.265–0.731). In the treatment group, the reduction in CRP was significantly, linearly and directly correlated with the reduction in the plaque index, the gingival index and the percentage of sites with pocket depth ‡ 7 mm (Pearson correlation coefficient = 0.746, 0.425 and 0.621, respectively). Nonsurgical periodontal therapy had no effect on the lipid parameters. Conclusion: This study demonstrated that nonsurgical periodontal therapy results in a significant reduction in the serum CRP level. The effect of this outcome on systemic disease is still unknown. John Wiley & Sons 2011-04-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23537/1/Effects_of_nonsurgical.pdf Kamil, Wisam Alaa and Habashnah, Rola and Khader, Yousef and Hilal Abbood Al-Bayati, Lina and Taani, D. (2011) Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis. Journal of Periodontal Research, 46 (5). pp. 616-621. ISSN 0022-3484 http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0765.2011.01380.x/pdf doi:10.1111/j.1600-0765.2011.01380.x
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RK Dentistry
spellingShingle	RK Dentistry Kamil, Wisam Alaa Habashnah, Rola Khader, Yousef Hilal Abbood Al-Bayati, Lina Taani, D. Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis
description	Background and Objective: Data on whether periodontal therapy affects serum CRP levels are inconclusive. The aim of this study was to determine if nonsurgical periodontal therapy has any effect on CRP and serum lipid levels in patients with advanced periodontitis. Material and Methods: Thirty-six systemically healthy patients, ‡ 40 years of age and with advanced periodontitis, were recruited for the study. Patients were randomized consecutively to one of two groups: the treatment group (n = 18) or the control group (n = 18). Treated subjects received nonsurgical periodontal therapy, which included oral hygiene instructions and subgingival scaling and root planing. Systemic levels of inflammatory markers [C-reactive protein (CRP) and the lipid profile] were measured at baseline and 3 mo after periodontal therapy. Results: Nonsurgical periodontal therapy in the treatment group resulted in a significant reduction in the serum CRP level. The average CRP level decreased from 2.3 mg/dL at baseline to 1.8 mg/dL (p < 0.005) after 3 mo of periodontal therapy. The average reduction (95% confidence interval) in CRP was 0.498 (95% confidence interval = 0.265–0.731). In the treatment group, the reduction in CRP was significantly, linearly and directly correlated with the reduction in the plaque index, the gingival index and the percentage of sites with pocket depth ‡ 7 mm (Pearson correlation coefficient = 0.746, 0.425 and 0.621, respectively). Nonsurgical periodontal therapy had no effect on the lipid parameters. Conclusion: This study demonstrated that nonsurgical periodontal therapy results in a significant reduction in the serum CRP level. The effect of this outcome on systemic disease is still unknown.
format	Article
author	Kamil, Wisam Alaa Habashnah, Rola Khader, Yousef Hilal Abbood Al-Bayati, Lina Taani, D.
author_facet	Kamil, Wisam Alaa Habashnah, Rola Khader, Yousef Hilal Abbood Al-Bayati, Lina Taani, D.
author_sort	Kamil, Wisam Alaa
title	Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis
title_short	Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis
title_full	Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis
title_fullStr	Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis
title_full_unstemmed	Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis
title_sort	effects of nonsurgical periodontal therapy on c-reactive protein and serum lipids in jordanian adults with advanced periodontitis
publisher	John Wiley & Sons
publishDate	2011
url	http://irep.iium.edu.my/23537/ http://irep.iium.edu.my/23537/ http://irep.iium.edu.my/23537/ http://irep.iium.edu.my/23537/1/Effects_of_nonsurgical.pdf
first_indexed	2023-09-18T20:35:36Z
last_indexed	2023-09-18T20:35:36Z
_version_	1777409024310902784

Effects of nonsurgical periodontal therapy on C-reactive protein and serum lipids in Jordanian adults with advanced periodontitis

Similar Items