Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides

The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions...

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Main Authors:	Wilkinson, Shane M., Liew, Chu W., Mackay, Joel P., Mohd. Salleh, Hamzah, Withers, Stephen G., McLeod, Malcolm D.
Format:	Article
Language:	English
Published:	American Chemical Society 2008
Subjects:	T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf

id	iium-23428
recordtype	eprints
spelling	iium-234282013-07-22T04:46:45Z http://irep.iium.edu.my/23428/ Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D. T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions. American Chemical Society 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf Wilkinson, Shane M. and Liew, Chu W. and Mackay, Joel P. and Mohd. Salleh, Hamzah and Withers, Stephen G. and McLeod, Malcolm D. (2008) Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides. Organic Letters, 10 (8). pp. 1585-1588. ISSN 1523-7060 http://pubs.acs.org/doi/abs/10.1021/ol8002767?journalCode=orlef7 10.1021/ol8002767
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology
spellingShingle	T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D. Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
description	The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions.
format	Article
author	Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D.
author_facet	Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D.
author_sort	Wilkinson, Shane M.
title	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_short	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_full	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_fullStr	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_full_unstemmed	Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
title_sort	escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
publisher	American Chemical Society
publishDate	2008
url	http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf
first_indexed	2023-09-18T20:35:27Z
last_indexed	2023-09-18T20:35:27Z
_version_	1777409015403249664

Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides

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