Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.

Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partiall...

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Main Authors: Mohd Yusoff, Noraini, Nuge, Tamrin, Zainan, Nor Hidayah, Hashim, Yumi Zuhanis Has-Yun, Jamal, Parveen, Meor Hussin, Anis Shobirin, Farouk Gad, Abd. El-Aziem, Mohd. Salleh, Hamzah
Format: Article
Language:English
Published: IIUM Press 2011
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Online Access:http://irep.iium.edu.my/23413/
http://irep.iium.edu.my/23413/1/Noraini_et_al_correct.pdf
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recordtype eprints
spelling iium-234132012-04-13T09:17:19Z http://irep.iium.edu.my/23413/ Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. Mohd Yusoff, Noraini Nuge, Tamrin Zainan, Nor Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk Gad, Abd. El-Aziem Mohd. Salleh, Hamzah T175 Industrial research. Research and development TP248.13 Biotechnology Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7 was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration. IIUM Press 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23413/1/Noraini_et_al_correct.pdf Mohd Yusoff, Noraini and Nuge, Tamrin and Zainan, Nor Hidayah and Hashim, Yumi Zuhanis Has-Yun and Jamal, Parveen and Meor Hussin, Anis Shobirin and Farouk Gad, Abd. El-Aziem and Mohd. Salleh, Hamzah (2011) Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. IIUM Engineering Journal, 12 (4). pp. 141-151. ISSN 1511-788X
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic T175 Industrial research. Research and development
TP248.13 Biotechnology
spellingShingle T175 Industrial research. Research and development
TP248.13 Biotechnology
Mohd Yusoff, Noraini
Nuge, Tamrin
Zainan, Nor Hidayah
Hashim, Yumi Zuhanis Has-Yun
Jamal, Parveen
Meor Hussin, Anis Shobirin
Farouk Gad, Abd. El-Aziem
Mohd. Salleh, Hamzah
Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.
description Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7 was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration.
format Article
author Mohd Yusoff, Noraini
Nuge, Tamrin
Zainan, Nor Hidayah
Hashim, Yumi Zuhanis Has-Yun
Jamal, Parveen
Meor Hussin, Anis Shobirin
Farouk Gad, Abd. El-Aziem
Mohd. Salleh, Hamzah
author_facet Mohd Yusoff, Noraini
Nuge, Tamrin
Zainan, Nor Hidayah
Hashim, Yumi Zuhanis Has-Yun
Jamal, Parveen
Meor Hussin, Anis Shobirin
Farouk Gad, Abd. El-Aziem
Mohd. Salleh, Hamzah
author_sort Mohd Yusoff, Noraini
title Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.
title_short Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.
title_full Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.
title_fullStr Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.
title_full_unstemmed Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.
title_sort preliminary investigation of myo-inositol phosphates produced by asuia279phytase on mcf-7 cancer cells.
publisher IIUM Press
publishDate 2011
url http://irep.iium.edu.my/23413/
http://irep.iium.edu.my/23413/1/Noraini_et_al_correct.pdf
first_indexed 2023-09-18T20:35:26Z
last_indexed 2023-09-18T20:35:26Z
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