Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells.
Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partiall...
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iium-234132012-04-13T09:17:19Z http://irep.iium.edu.my/23413/ Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. Mohd Yusoff, Noraini Nuge, Tamrin Zainan, Nor Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk Gad, Abd. El-Aziem Mohd. Salleh, Hamzah T175 Industrial research. Research and development TP248.13 Biotechnology Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7 was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration. IIUM Press 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23413/1/Noraini_et_al_correct.pdf Mohd Yusoff, Noraini and Nuge, Tamrin and Zainan, Nor Hidayah and Hashim, Yumi Zuhanis Has-Yun and Jamal, Parveen and Meor Hussin, Anis Shobirin and Farouk Gad, Abd. El-Aziem and Mohd. Salleh, Hamzah (2011) Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. IIUM Engineering Journal, 12 (4). pp. 141-151. ISSN 1511-788X |
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T175 Industrial research. Research and development TP248.13 Biotechnology |
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T175 Industrial research. Research and development TP248.13 Biotechnology Mohd Yusoff, Noraini Nuge, Tamrin Zainan, Nor Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk Gad, Abd. El-Aziem Mohd. Salleh, Hamzah Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
description |
Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7
was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates
degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration.
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format |
Article |
author |
Mohd Yusoff, Noraini Nuge, Tamrin Zainan, Nor Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk Gad, Abd. El-Aziem Mohd. Salleh, Hamzah |
author_facet |
Mohd Yusoff, Noraini Nuge, Tamrin Zainan, Nor Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk Gad, Abd. El-Aziem Mohd. Salleh, Hamzah |
author_sort |
Mohd Yusoff, Noraini |
title |
Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
title_short |
Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
title_full |
Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
title_fullStr |
Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
title_full_unstemmed |
Preliminary investigation of Myo-Inositol Phosphates produced by Asuia279phytase on Mcf-7 cancer cells. |
title_sort |
preliminary investigation of myo-inositol phosphates produced by asuia279phytase on mcf-7 cancer cells. |
publisher |
IIUM Press |
publishDate |
2011 |
url |
http://irep.iium.edu.my/23413/ http://irep.iium.edu.my/23413/1/Noraini_et_al_correct.pdf |
first_indexed |
2023-09-18T20:35:26Z |
last_indexed |
2023-09-18T20:35:26Z |
_version_ |
1777409013836677120 |