Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country

INTRODUCTION: Prolonged use of oral conicostero,as ,s a risk factor for osteoporosis. However, the effect of inhaled corticos-teroids (CS) on bone mineral density (ENID) of asthmatic patients remains controversial. OBJECTIVES. We aimed to determine the prevalence of osteopenia and osteoporosis in...

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Main Authors:	Kuan, Yeh Chunn, How, Soon Hin, Abd. Aziz, Azian, Chong, Kin Liam, Ng, Teck Han, Abdul Rani, Mohammed Fauzi
Format:	Article
Language:	English
Published:	Medknow Publications 2012
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/23183/ http://irep.iium.edu.my/23183/ http://irep.iium.edu.my/23183/ http://irep.iium.edu.my/23183/1/Bone_mineral_density_in_asthmatic_patients_on_inhaled_corticosteroids.pdf

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spelling	iium-231832013-04-27T08:31:32Z http://irep.iium.edu.my/23183/ Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country Kuan, Yeh Chunn How, Soon Hin Abd. Aziz, Azian Chong, Kin Liam Ng, Teck Han Abdul Rani, Mohammed Fauzi R Medicine (General) INTRODUCTION: Prolonged use of oral conicostero,as ,s a risk factor for osteoporosis. However, the effect of inhaled corticos-teroids (CS) on bone mineral density (ENID) of asthmatic patients remains controversial. OBJECTIVES. We aimed to determine the prevalence of osteopenia and osteoporosis in our patients with asthma receiving ICSs for more than one year compared with patients who did not have asthma and to determine the risk factors for osteopenia and osteoporosis among the asthmatic patients. METHODS: This was a cross-sectional study conducted from August 2007 to July 2009. Asthmatic patients aged la years and older who had been on ICS for at least one year and a control group of subjects not on ICS were included. BMD was measured using DEXA (dual energy X-ray absorptiometry) scan. The WHO classification of T•scOreS for osteopenia and osteoporosis were used. RESULTS, A total 01 143 subjects were recruited (69 asthmatics and 74 control subjects). T-scores of the spine, femur, and hip of the asthmatics vs the control subjects were mean, -0,72 VS -0 .57 (P = 0.98): median, -0.60 vs -0,80 (P=0 474), and mean, 0,19 vs 0.06 (P=0.275), respectively. T-scores of the spine, lemur, and hip showed significant negative correlation with age and significant positive correlation with body mass index (13M1), CONCLUSIONI The risk factors for osteoporosis and osteopenia among asthmatic patients were older age and lower BMI, but not the cumulative dose of ICS. Asthmatic patients on ICS have no added risk of osteoporosis or ostecpenia as compared with non-asthmatic subjects. Key words: Asthma, asthma, bone mineral density, inhaled corticosteroilds Medknow Publications 2012-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23183/1/Bone_mineral_density_in_asthmatic_patients_on_inhaled_corticosteroids.pdf Kuan, Yeh Chunn and How, Soon Hin and Abd. Aziz, Azian and Chong, Kin Liam and Ng, Teck Han and Abdul Rani, Mohammed Fauzi (2012) Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country. Annals of Thoracic Medicine, 7 (2). pp. 69-73. ISSN 1998-3557 (O) 1817-1737 (P) http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2012;volume=7;issue=2;spage=69;epage=73;aulast=Kuan 10.4103/1817-1737.94522
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Kuan, Yeh Chunn How, Soon Hin Abd. Aziz, Azian Chong, Kin Liam Ng, Teck Han Abdul Rani, Mohammed Fauzi Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country
description	INTRODUCTION: Prolonged use of oral conicostero,as ,s a risk factor for osteoporosis. However, the effect of inhaled corticos-teroids (CS) on bone mineral density (ENID) of asthmatic patients remains controversial. OBJECTIVES. We aimed to determine the prevalence of osteopenia and osteoporosis in our patients with asthma receiving ICSs for more than one year compared with patients who did not have asthma and to determine the risk factors for osteopenia and osteoporosis among the asthmatic patients. METHODS: This was a cross-sectional study conducted from August 2007 to July 2009. Asthmatic patients aged la years and older who had been on ICS for at least one year and a control group of subjects not on ICS were included. BMD was measured using DEXA (dual energy X-ray absorptiometry) scan. The WHO classification of T•scOreS for osteopenia and osteoporosis were used. RESULTS, A total 01 143 subjects were recruited (69 asthmatics and 74 control subjects). T-scores of the spine, femur, and hip of the asthmatics vs the control subjects were mean, -0,72 VS -0 .57 (P = 0.98): median, -0.60 vs -0,80 (P=0 474), and mean, 0,19 vs 0.06 (P=0.275), respectively. T-scores of the spine, lemur, and hip showed significant negative correlation with age and significant positive correlation with body mass index (13M1), CONCLUSIONI The risk factors for osteoporosis and osteopenia among asthmatic patients were older age and lower BMI, but not the cumulative dose of ICS. Asthmatic patients on ICS have no added risk of osteoporosis or ostecpenia as compared with non-asthmatic subjects. Key words: Asthma, asthma, bone mineral density, inhaled corticosteroilds
format	Article
author	Kuan, Yeh Chunn How, Soon Hin Abd. Aziz, Azian Chong, Kin Liam Ng, Teck Han Abdul Rani, Mohammed Fauzi
author_facet	Kuan, Yeh Chunn How, Soon Hin Abd. Aziz, Azian Chong, Kin Liam Ng, Teck Han Abdul Rani, Mohammed Fauzi
author_sort	Kuan, Yeh Chunn
title	Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country
title_short	Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country
title_full	Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country
title_fullStr	Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country
title_full_unstemmed	Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country
title_sort	bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country
publisher	Medknow Publications
publishDate	2012
url	http://irep.iium.edu.my/23183/ http://irep.iium.edu.my/23183/ http://irep.iium.edu.my/23183/ http://irep.iium.edu.my/23183/1/Bone_mineral_density_in_asthmatic_patients_on_inhaled_corticosteroids.pdf
first_indexed	2023-09-18T20:35:12Z
last_indexed	2023-09-18T20:35:12Z
_version_	1777408999157661696

Bone mineral density in asthmatic patients on inhaled corticosteroids in a developing country

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