Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life

Background: With evolving evidence of association between tuberculosis (TB) and tobacco smoking,recommendations for the inclusion of tobacco cessation interventions in TB care are becoming increasingly important and more widely disseminated. Connecting TB and tobacco cessation interventions has been...

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Main Authors:	Awaisu, Ahmed, Nik Mohamed, Mohamad Haniki, Mohamad Noordin, Noorliza, Muttalif, Abdul Razak, Abd Aziz, Noorizan, Syed Sulaiman, Syed Azhar, Ahmad Mahayiddin, Aziah
Format:	Article
Language:	English
Published:	BioMed Central 2012
Online Access:	http://irep.iium.edu.my/23073/ http://irep.iium.edu.my/23073/ http://irep.iium.edu.my/23073/1/Impact_of_connecting_tuberculosis_directly_observed_therapy_short-course_with_smoking_cessation_on_health-related_quality_of_life.pdf

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spelling	iium-230732013-02-04T06:56:25Z http://irep.iium.edu.my/23073/ Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life Awaisu, Ahmed Nik Mohamed, Mohamad Haniki Mohamad Noordin, Noorliza Muttalif, Abdul Razak Abd Aziz, Noorizan Syed Sulaiman, Syed Azhar Ahmad Mahayiddin, Aziah Background: With evolving evidence of association between tuberculosis (TB) and tobacco smoking,recommendations for the inclusion of tobacco cessation interventions in TB care are becoming increasingly important and more widely disseminated. Connecting TB and tobacco cessation interventions has been strongly advocated as this may yield better outcomes. However, no study has documented the impact of such connection on health-related quality of life (HRQoL). The objective of this study was to document the impact of an integrated TB directly observed therapy short-course (DOTS) plus smoking cessation intervention (SCI) on HRQoL. Methods: This was a multi-centered non-randomized controlled study involving 120 TB patients who were current smokers at the time of TB diagnosis in Malaysia. Patients were assigned to either of two groups: the usual TB-DOTS plus SCI (SCIDOTS group) or the usual TB-DOTS only (DOTS group). The effect of the novel strategy on HRQoL was measured using EQ-5D questionnaire. Two-way repeated measure ANOVA was used to examine the effects. Results: When compared, participants who received the integrated intervention had a better HRQoL than those who received the usual TB care. The SCIDOTS group had a significantly greater increase in EQ-5D utility score than the DOTS group during 6 months follow-up (mean ± SD = 0.98 ± 0.08 vs. 0.91 ± 0.14, p = 0.006). Similarly, the mean scores for EQ-VAS showed a consistently similar trend as the EQ-5D indices, with the scores increasing over the course of TB treatment. Furthermore, for the EQ-VAS, there were significant main effects for group [F (1, 84) = 4.91, p = 0.029, h2 = 0.06], time [F (2, 168) = 139.50, p = < 0.001, h2 = 0.62] and group x time interaction [F (2, 168) = 13.89, p = < 0.001, h2 = 0.14]. Conclusions: This study supports the evidence that an integrated TB-tobacco treatment strategy could potentially improve overall quality of life outcomes among TB patients who are smokers. BioMed Central 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23073/1/Impact_of_connecting_tuberculosis_directly_observed_therapy_short-course_with_smoking_cessation_on_health-related_quality_of_life.pdf Awaisu, Ahmed and Nik Mohamed, Mohamad Haniki and Mohamad Noordin, Noorliza and Muttalif, Abdul Razak and Abd Aziz, Noorizan and Syed Sulaiman, Syed Azhar and Ahmad Mahayiddin, Aziah (2012) Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life. Tobacco Induced Diseases, 10 (2). ISSN 1617-9625 DOI: 10.1186/1617-9625-10-2
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
description	Background: With evolving evidence of association between tuberculosis (TB) and tobacco smoking,recommendations for the inclusion of tobacco cessation interventions in TB care are becoming increasingly important and more widely disseminated. Connecting TB and tobacco cessation interventions has been strongly advocated as this may yield better outcomes. However, no study has documented the impact of such connection on health-related quality of life (HRQoL). The objective of this study was to document the impact of an integrated TB directly observed therapy short-course (DOTS) plus smoking cessation intervention (SCI) on HRQoL. Methods: This was a multi-centered non-randomized controlled study involving 120 TB patients who were current smokers at the time of TB diagnosis in Malaysia. Patients were assigned to either of two groups: the usual TB-DOTS plus SCI (SCIDOTS group) or the usual TB-DOTS only (DOTS group). The effect of the novel strategy on HRQoL was measured using EQ-5D questionnaire. Two-way repeated measure ANOVA was used to examine the effects. Results: When compared, participants who received the integrated intervention had a better HRQoL than those who received the usual TB care. The SCIDOTS group had a significantly greater increase in EQ-5D utility score than the DOTS group during 6 months follow-up (mean ± SD = 0.98 ± 0.08 vs. 0.91 ± 0.14, p = 0.006). Similarly, the mean scores for EQ-VAS showed a consistently similar trend as the EQ-5D indices, with the scores increasing over the course of TB treatment. Furthermore, for the EQ-VAS, there were significant main effects for group [F (1, 84) = 4.91, p = 0.029, h2 = 0.06], time [F (2, 168) = 139.50, p = < 0.001, h2 = 0.62] and group x time interaction [F (2, 168) = 13.89, p = < 0.001, h2 = 0.14]. Conclusions: This study supports the evidence that an integrated TB-tobacco treatment strategy could potentially improve overall quality of life outcomes among TB patients who are smokers.
format	Article
author	Awaisu, Ahmed Nik Mohamed, Mohamad Haniki Mohamad Noordin, Noorliza Muttalif, Abdul Razak Abd Aziz, Noorizan Syed Sulaiman, Syed Azhar Ahmad Mahayiddin, Aziah
spellingShingle	Awaisu, Ahmed Nik Mohamed, Mohamad Haniki Mohamad Noordin, Noorliza Muttalif, Abdul Razak Abd Aziz, Noorizan Syed Sulaiman, Syed Azhar Ahmad Mahayiddin, Aziah Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life
author_facet	Awaisu, Ahmed Nik Mohamed, Mohamad Haniki Mohamad Noordin, Noorliza Muttalif, Abdul Razak Abd Aziz, Noorizan Syed Sulaiman, Syed Azhar Ahmad Mahayiddin, Aziah
author_sort	Awaisu, Ahmed
title	Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life
title_short	Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life
title_full	Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life
title_fullStr	Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life
title_full_unstemmed	Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life
title_sort	impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life
publisher	BioMed Central
publishDate	2012
url	http://irep.iium.edu.my/23073/ http://irep.iium.edu.my/23073/ http://irep.iium.edu.my/23073/1/Impact_of_connecting_tuberculosis_directly_observed_therapy_short-course_with_smoking_cessation_on_health-related_quality_of_life.pdf
first_indexed	2023-09-18T20:34:57Z
last_indexed	2023-09-18T20:34:57Z
_version_	1777408984196579328

Impact of connecting tuberculosis directly observed therapy short-course with smoking cessation on health-related quality of life

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