Terpenoids from the stem bark of jatropha plants And their biological activities

Three terpenoids, including two diterpenes (curcusone B and jatrophone) and a triterpene (stigmasterol) have been isolated from the stem bark of Jatropha plants. Curcusone B and stigmasterol were isolated from J. curcas, meanwhile jatrophone and stigmasterol were from J. gossypifolia. The biologic...

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Main Authors:	Sahidin, Sahidin, Ardiyansyah, Sahidin, Bakhtiar, M. Taher, Marianti , Mangau
Format:	Article
Language:	English
Published:	Universitas Indonesia 2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/22936/ http://irep.iium.edu.my/22936/ http://irep.iium.edu.my/22936/1/Makara_science.pdf

id	iium-22936
recordtype	eprints
spelling	iium-229362014-04-04T10:36:17Z http://irep.iium.edu.my/22936/ Terpenoids from the stem bark of jatropha plants And their biological activities Sahidin, Sahidin Ardiyansyah, Sahidin Bakhtiar, M. Taher Marianti , Mangau RS Pharmacy and materia medica Three terpenoids, including two diterpenes (curcusone B and jatrophone) and a triterpene (stigmasterol) have been isolated from the stem bark of Jatropha plants. Curcusone B and stigmasterol were isolated from J. curcas, meanwhile jatrophone and stigmasterol were from J. gossypifolia. The biological activities of these compounds have been evaluated toward bacteria, fungi and tumour cells. Isolation was carried out in vacuum liqiud cromatography (VLC)technique with silica gel as an adsorben and some solvents as eluents. The compound structures were determined by spectroscopic methodes i.e. UV-vis, FTIR, NMR (1-D, 2-D) and were then compared based on their spectroscopic data with similiar data from literatures. The biological properties of these compounds were evaluated against four strains of bacteria (Acetobacter sp., Eschericia coli, Staphylococcus aureus, and Streptococcus sp.), 4 strains of fungi (Aspergilus niger, Penicillium sp. (grey), Penicillium sp. (white) and Rhizopus sp.) and murine leukemia P-388 cells. The results showed that cytotoxic property of curcusone B towards murine leukemia P-388 cells is better than jatrophone and stigmasterol which are IC50 = 0.57 μg/mL (1.93 μM) for curcusone B and IC50 > 100 μg/mL for jatrophone and stigmasterol. Meanwhile, activities against bacteria, jatrophone is better than curcusone B and stigmasterol. Jatrophone is the most active against S. aureus (bacteria) with growth inhibition zone 36 mm and A.niger (fungi) is 44 mm. Further study indicated that jatrophone was bacteriostatic against S. aureus. Universitas Indonesia 2011-11 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/22936/1/Makara_science.pdf Sahidin, Sahidin and Ardiyansyah, Sahidin and Bakhtiar, M. Taher and Marianti , Mangau (2011) Terpenoids from the stem bark of jatropha plants And their biological activities. Makara of Science Series, 15 (2). pp. 106-110. ISSN 1693-6671 http://journal.ui.ac.id/science/article/view/945
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Sahidin, Sahidin Ardiyansyah, Sahidin Bakhtiar, M. Taher Marianti , Mangau Terpenoids from the stem bark of jatropha plants And their biological activities
description	Three terpenoids, including two diterpenes (curcusone B and jatrophone) and a triterpene (stigmasterol) have been isolated from the stem bark of Jatropha plants. Curcusone B and stigmasterol were isolated from J. curcas, meanwhile jatrophone and stigmasterol were from J. gossypifolia. The biological activities of these compounds have been evaluated toward bacteria, fungi and tumour cells. Isolation was carried out in vacuum liqiud cromatography (VLC)technique with silica gel as an adsorben and some solvents as eluents. The compound structures were determined by spectroscopic methodes i.e. UV-vis, FTIR, NMR (1-D, 2-D) and were then compared based on their spectroscopic data with similiar data from literatures. The biological properties of these compounds were evaluated against four strains of bacteria (Acetobacter sp., Eschericia coli, Staphylococcus aureus, and Streptococcus sp.), 4 strains of fungi (Aspergilus niger, Penicillium sp. (grey), Penicillium sp. (white) and Rhizopus sp.) and murine leukemia P-388 cells. The results showed that cytotoxic property of curcusone B towards murine leukemia P-388 cells is better than jatrophone and stigmasterol which are IC50 = 0.57 μg/mL (1.93 μM) for curcusone B and IC50 > 100 μg/mL for jatrophone and stigmasterol. Meanwhile, activities against bacteria, jatrophone is better than curcusone B and stigmasterol. Jatrophone is the most active against S. aureus (bacteria) with growth inhibition zone 36 mm and A.niger (fungi) is 44 mm. Further study indicated that jatrophone was bacteriostatic against S. aureus.
format	Article
author	Sahidin, Sahidin Ardiyansyah, Sahidin Bakhtiar, M. Taher Marianti , Mangau
author_facet	Sahidin, Sahidin Ardiyansyah, Sahidin Bakhtiar, M. Taher Marianti , Mangau
author_sort	Sahidin, Sahidin
title	Terpenoids from the stem bark of jatropha plants And their biological activities
title_short	Terpenoids from the stem bark of jatropha plants And their biological activities
title_full	Terpenoids from the stem bark of jatropha plants And their biological activities
title_fullStr	Terpenoids from the stem bark of jatropha plants And their biological activities
title_full_unstemmed	Terpenoids from the stem bark of jatropha plants And their biological activities
title_sort	terpenoids from the stem bark of jatropha plants and their biological activities
publisher	Universitas Indonesia
publishDate	2011
url	http://irep.iium.edu.my/22936/ http://irep.iium.edu.my/22936/ http://irep.iium.edu.my/22936/1/Makara_science.pdf
first_indexed	2023-09-18T20:34:49Z
last_indexed	2023-09-18T20:34:49Z
_version_	1777408975541633024

Terpenoids from the stem bark of jatropha plants And their biological activities

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