Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
INSI Publications
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/20337/ http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf |
| Summary: | This study was designed to determine antiproliferative properties of curcusone B from the
stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299
(human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various
concentrations and the percentage of cell viability was evaluated by trypan blue exclusion method and
MTT assay. Curcusone B showed significant dose-dependent inhibition of cell proliferation of K562
and H1299 cell lines with an IC50 of 6 μg/mL and 15.0 μg/mL, respectively. The findings suggested
that the curcusone B had strong antiproliferation which was dose dependent and may have potential
as an anticancer agent. |
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