Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo.

The leaves of Murraya koenigii (Linn.) Spreng (curry leaf) is widely use a nephroprotective agent in Kidney's infirmities among diabetics by the traditional practitioners in Malaysia. However, the latter role of curry leaf has been grossly under reported and is yet to receive proper scientific...

Full description

Bibliographic Details
Main Authors:	Yankuzo, Hassan, Santosa, Rahajoe Imam, Ahmed, Qamar Uddin, Akter, Seikh Farid Uddin, A.Talib, Norlelawati
Format:	Conference or Workshop Item
Language:	English
Published:	2010
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://irep.iium.edu.my/18885/ http://irep.iium.edu.my/18885/ http://irep.iium.edu.my/18885/1/Nephroprotective_effect.pdf

id	iium-18885
recordtype	eprints
spelling	iium-188852013-04-12T09:47:07Z http://irep.iium.edu.my/18885/ Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo. Yankuzo, Hassan Santosa, Rahajoe Imam Ahmed, Qamar Uddin Akter, Seikh Farid Uddin A.Talib, Norlelawati R Medicine (General) RB Pathology The leaves of Murraya koenigii (Linn.) Spreng (curry leaf) is widely use a nephroprotective agent in Kidney's infirmities among diabetics by the traditional practitioners in Malaysia. However, the latter role of curry leaf has been grossly under reported and is yet to receive proper scientific evaluation. The present study was designed to investigate the beneficial effect of the leaves of M. koenigii (L.) on diabetes-induced renal damage in vivo with regard to prove its efficacy by local traditional practitioners in the treatment of kidney frailties in diabetics. Aqueous (AQ) extract of the leaves of M. koenigii (L.) was administered to both normal and streptozotocin (STZ) induced diabetic male rats (Spraque Dawley strain). Animals were divided into six groups (n=6) and treated with variable dose levels of AQ extract (200&400 mg/kg body weight/day) for 30 days. At the end of 30 days, animals were sacrificed, blood and collected, processed and stored at -70*C for the estimation of serum urea and creatinine, changes in plasma antioxidant capacity by FRAP assay, and lipid peroxidation, in the normal and STZ induced diabetic rats. Histological studies of the Kidneys of these animals were also studied by light microscopy to determine the beneficial effect of leaves. Daily oral administration of variable dose levels of the AQ extract for 30 days, produced significant dose dependant decrease in serum urea and creatinine levels (p<0.001) as well as in the elevated lipid hydroperoxides (p<0.05) in diabetic treated rats compared to the control (non-diabetic) subjects. It also markedly improved plasma antioxidant concentration (p<0.01) in both normal and treated diabetic rats, respectively. However, the normal treated rats showed minimal variation in these parameters in comparison to normal controls. Histological studies of the kidneys of these animals explicitly showed comparable tissue regeneration by the AQ extract. Conclusion: The results of our study scientifically support the traditional belief for using the leaves of M. koenigii (L.) in the treatment of pain disorders related to renal impairments among diabetics. 2010 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/18885/1/Nephroprotective_effect.pdf Yankuzo, Hassan and Santosa, Rahajoe Imam and Ahmed, Qamar Uddin and Akter, Seikh Farid Uddin and A.Talib, Norlelawati (2010) Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo. In: 3rd International Conference on Advancement in Science and Technology (iCAST) 2010, 27-29 November 2010, Vistana Hotel, Kuantan, Pahang. http://www.iium.edu.my/icast/2010/index.php?option=com_content&view=article&id=14&Itemid=17
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Yankuzo, Hassan Santosa, Rahajoe Imam Ahmed, Qamar Uddin Akter, Seikh Farid Uddin A.Talib, Norlelawati Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo.
description	The leaves of Murraya koenigii (Linn.) Spreng (curry leaf) is widely use a nephroprotective agent in Kidney's infirmities among diabetics by the traditional practitioners in Malaysia. However, the latter role of curry leaf has been grossly under reported and is yet to receive proper scientific evaluation. The present study was designed to investigate the beneficial effect of the leaves of M. koenigii (L.) on diabetes-induced renal damage in vivo with regard to prove its efficacy by local traditional practitioners in the treatment of kidney frailties in diabetics. Aqueous (AQ) extract of the leaves of M. koenigii (L.) was administered to both normal and streptozotocin (STZ) induced diabetic male rats (Spraque Dawley strain). Animals were divided into six groups (n=6) and treated with variable dose levels of AQ extract (200&400 mg/kg body weight/day) for 30 days. At the end of 30 days, animals were sacrificed, blood and collected, processed and stored at -70*C for the estimation of serum urea and creatinine, changes in plasma antioxidant capacity by FRAP assay, and lipid peroxidation, in the normal and STZ induced diabetic rats. Histological studies of the Kidneys of these animals were also studied by light microscopy to determine the beneficial effect of leaves. Daily oral administration of variable dose levels of the AQ extract for 30 days, produced significant dose dependant decrease in serum urea and creatinine levels (p<0.001) as well as in the elevated lipid hydroperoxides (p<0.05) in diabetic treated rats compared to the control (non-diabetic) subjects. It also markedly improved plasma antioxidant concentration (p<0.01) in both normal and treated diabetic rats, respectively. However, the normal treated rats showed minimal variation in these parameters in comparison to normal controls. Histological studies of the kidneys of these animals explicitly showed comparable tissue regeneration by the AQ extract. Conclusion: The results of our study scientifically support the traditional belief for using the leaves of M. koenigii (L.) in the treatment of pain disorders related to renal impairments among diabetics.
format	Conference or Workshop Item
author	Yankuzo, Hassan Santosa, Rahajoe Imam Ahmed, Qamar Uddin Akter, Seikh Farid Uddin A.Talib, Norlelawati
author_facet	Yankuzo, Hassan Santosa, Rahajoe Imam Ahmed, Qamar Uddin Akter, Seikh Farid Uddin A.Talib, Norlelawati
author_sort	Yankuzo, Hassan
title	Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo.
title_short	Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo.
title_full	Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo.
title_fullStr	Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo.
title_full_unstemmed	Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo.
title_sort	nephroprotective effect of the leaves of murraya koenigii l. spreng in vivo.
publishDate	2010
url	http://irep.iium.edu.my/18885/ http://irep.iium.edu.my/18885/ http://irep.iium.edu.my/18885/1/Nephroprotective_effect.pdf
first_indexed	2023-09-18T20:28:08Z
last_indexed	2023-09-18T20:28:08Z
_version_	1777408554592894976

Nephroprotective effect of the leaves of Murraya koenigii L. Spreng in vivo.

Similar Items