In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease

The antifungal activity of crude extracts from the stem bark of Entada spiralis was evaluated in vitro against human dermatophytes by disc diffusion method. Three types of human dermatophytes, known as Trichophyton mentagrophytes, Microsporum gypseum, Trichophyton tonsurans and one non-dermatophyteC...

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Main Authors:	Harun, Aiza, Mat So'ad, Siti Zaiton, Mohd Hassan, Norazian, Che Mohd Ramli, Neni Kartini
Format:	Article
Language:	English English
Published:	Kulliyyah of Science, IIUM 2011
Subjects:	RM Therapeutics. Pharmacology RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/18687/ http://irep.iium.edu.my/18687/ http://irep.iium.edu.my/18687/2/19-39-1-PB.pdf http://irep.iium.edu.my/18687/1/in_vitro.pdf

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recordtype	eprints
spelling	iium-186872012-02-16T03:10:18Z http://irep.iium.edu.my/18687/ In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini RM Therapeutics. Pharmacology RM300 Drugs and their action The antifungal activity of crude extracts from the stem bark of Entada spiralis was evaluated in vitro against human dermatophytes by disc diffusion method. Three types of human dermatophytes, known as Trichophyton mentagrophytes, Microsporum gypseum, Trichophyton tonsurans and one non-dermatophyteCandida glabrata, were tested against petroleum ether, ethyl acetate and methanol crude extracts of the E. spiralis. Results revealed that all dermatophytes were susceptible towards all tested crude extracts, whereas, the non-dermatophyte showed resistance to all the extracts. M. gypseum was found to be most susceptible towards petroleum ether extract (400mg/ml), with a zone of inhibition of 16 mm. The ethyl acetate and methanol crude extracts (400mg/ml each) exhibited highest activity against T. tonsurans with inhibition zones of 12.7 mm and 11.5 mm, respectively. Nystatin was used as the standard antifungal drug in all experiments and served as the positive control. All these results suggested that the petroleum ether crude extract was the most active extract against all tested dermatophytes except for C. glabrata. Based on these current findings, it can be concluded that the stem bark extracts of E. spiralis have promising antifungal activities and can be used as a potent antifungal drug against certain dermatophytes. Kulliyyah of Science, IIUM 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/18687/2/19-39-1-PB.pdf application/pdf en http://irep.iium.edu.my/18687/1/in_vitro.pdf Harun, Aiza and Mat So'ad, Siti Zaiton and Mohd Hassan, Norazian and Che Mohd Ramli, Neni Kartini (2011) In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease. Revelation and Science, 01 (01). pp. 57-61. ISSN 2229-9947 http://www.iium.edu.my/revival/index.php/revival/article/view/19
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology RM300 Drugs and their action
spellingShingle	RM Therapeutics. Pharmacology RM300 Drugs and their action Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease
description	The antifungal activity of crude extracts from the stem bark of Entada spiralis was evaluated in vitro against human dermatophytes by disc diffusion method. Three types of human dermatophytes, known as Trichophyton mentagrophytes, Microsporum gypseum, Trichophyton tonsurans and one non-dermatophyteCandida glabrata, were tested against petroleum ether, ethyl acetate and methanol crude extracts of the E. spiralis. Results revealed that all dermatophytes were susceptible towards all tested crude extracts, whereas, the non-dermatophyte showed resistance to all the extracts. M. gypseum was found to be most susceptible towards petroleum ether extract (400mg/ml), with a zone of inhibition of 16 mm. The ethyl acetate and methanol crude extracts (400mg/ml each) exhibited highest activity against T. tonsurans with inhibition zones of 12.7 mm and 11.5 mm, respectively. Nystatin was used as the standard antifungal drug in all experiments and served as the positive control. All these results suggested that the petroleum ether crude extract was the most active extract against all tested dermatophytes except for C. glabrata. Based on these current findings, it can be concluded that the stem bark extracts of E. spiralis have promising antifungal activities and can be used as a potent antifungal drug against certain dermatophytes.
format	Article
author	Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini
author_facet	Harun, Aiza Mat So'ad, Siti Zaiton Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini
author_sort	Harun, Aiza
title	In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease
title_short	In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease
title_full	In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease
title_fullStr	In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease
title_full_unstemmed	In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease
title_sort	in vitro study of antifungal activity of entada spiralis ridl. crude extract against dermatophytes of superficial skin disease
publisher	Kulliyyah of Science, IIUM
publishDate	2011
url	http://irep.iium.edu.my/18687/ http://irep.iium.edu.my/18687/ http://irep.iium.edu.my/18687/2/19-39-1-PB.pdf http://irep.iium.edu.my/18687/1/in_vitro.pdf
first_indexed	2023-09-18T20:27:51Z
last_indexed	2023-09-18T20:27:51Z
_version_	1777408536623448064

In vitro study of antifungal activity of Entada spiralis Ridl. crude extract against dermatophytes of superficial skin disease

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