Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.

Crystallization is an important unit operation used in a variety of industries. Its importance in the pharmaceutical industries is due to a large number of active pharmaceutical ingredients that are utilised in solid form. It is estimated that more than 80% ofpharmaceutical products involve at least...

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Main Authors:	Abu Bakar, Mohd Rushdi, Nagy, Zoltan K.
Format:	Book Chapter
Language:	English
Published:	IIUM Press 2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/18493/ http://irep.iium.edu.my/18493/ http://irep.iium.edu.my/18493/1/CHAPTER_8%5B1%5D.pdf

id	iium-18493
recordtype	eprints
spelling	iium-184932012-08-27T07:24:18Z http://irep.iium.edu.my/18493/ Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. Abu Bakar, Mohd Rushdi Nagy, Zoltan K. RS Pharmacy and materia medica Crystallization is an important unit operation used in a variety of industries. Its importance in the pharmaceutical industries is due to a large number of active pharmaceutical ingredients that are utilised in solid form. It is estimated that more than 80% ofpharmaceutical products involve at least one crystallization step in their manufacturing process (Reutzel-Edens, 2006). The pharmaceutical crystallisation operation is often critical because it determines the product properties, such as the crystal size distribution, morphology and polymorphic form. These properties in tum influence the efficiency of the subsequent downstream operations, particularly filtration and drying. The properties also affect the therapeutic performance ofthe product, such as dissolution rate and bioavailability. A proper control of crystallization processes offers possibilities for improved process efficiency and better product quality IIUM Press 2011 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/18493/1/CHAPTER_8%5B1%5D.pdf Abu Bakar, Mohd Rushdi and Nagy, Zoltan K. (2011) Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes. In: Current Issues in Pharmacy. IIUM Press, Kuala Lumpur , pp. 129-155. ISBN 9789674180195 http://rms.research.iium.edu.my/bookstore/default.aspx
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.
description	Crystallization is an important unit operation used in a variety of industries. Its importance in the pharmaceutical industries is due to a large number of active pharmaceutical ingredients that are utilised in solid form. It is estimated that more than 80% ofpharmaceutical products involve at least one crystallization step in their manufacturing process (Reutzel-Edens, 2006). The pharmaceutical crystallisation operation is often critical because it determines the product properties, such as the crystal size distribution, morphology and polymorphic form. These properties in tum influence the efficiency of the subsequent downstream operations, particularly filtration and drying. The properties also affect the therapeutic performance ofthe product, such as dissolution rate and bioavailability. A proper control of crystallization processes offers possibilities for improved process efficiency and better product quality
format	Book Chapter
author	Abu Bakar, Mohd Rushdi Nagy, Zoltan K.
author_facet	Abu Bakar, Mohd Rushdi Nagy, Zoltan K.
author_sort	Abu Bakar, Mohd Rushdi
title	Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.
title_short	Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.
title_full	Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.
title_fullStr	Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.
title_full_unstemmed	Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.
title_sort	process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.
publisher	IIUM Press
publishDate	2011
url	http://irep.iium.edu.my/18493/ http://irep.iium.edu.my/18493/ http://irep.iium.edu.my/18493/1/CHAPTER_8%5B1%5D.pdf
first_indexed	2023-09-18T20:27:36Z
last_indexed	2023-09-18T20:27:36Z
_version_	1777408521367715840

Process analytical technology based monitoring and control of crystal properties in pharmaceutical crystallisation processes.

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