Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients

Introduction: This study aims to determine the prevalence and the types of menstrual disorders among patients with systemic lupus erythematosus (SLE) and to identify factors that influence their development. Methods: 61 patients with SLE were enrolled into a cross-sectional, observational stud...

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Main Authors:	Mohd Shah, Azarisman Shah, NNA, Fatnoon, D, Zainal
Format:	Article
Language:	English
Published:	Singapore Medical Association 2008
Subjects:	RC Internal medicine
Online Access:	http://irep.iium.edu.my/17142/ http://irep.iium.edu.my/17142/ http://irep.iium.edu.my/17142/1/Prevalence_and_Risk_Factors_for_Menstrual.pdf

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spelling	iium-171422012-01-26T08:42:44Z http://irep.iium.edu.my/17142/ Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients Mohd Shah, Azarisman Shah NNA, Fatnoon D, Zainal RC Internal medicine Introduction: This study aims to determine the prevalence and the types of menstrual disorders among patients with systemic lupus erythematosus (SLE) and to identify factors that influence their development. Methods: 61 patients with SLE were enrolled into a cross-sectional, observational study at the medical outpatient clinic, Hospital Universiti Sains Malaysia. A total of 120 healthy women were selected randomly to act as the control group. A questionnaire was administered, vital signs were recorded, and blood was evaluated for routine investigations. A review of past medical records was also undertaken. Results: The mean age and standard deviation for the study group was 33.23 +/- 10.96 years, the majority being ethnic Malays. 75 percent had a severe SLE disease activity index score on initial presentation, and 59 percent were on cyclophosphamide. 49 percent of the study population had menstrual irregularities, of which 60 percent had sustained amenorrhoea. Nine patients with sustained amenorrhoea had hormonal assays, which confirmed the diagnosis of premature menopause. Conclusion: This study showed that SLE patients had a higher risk of developing menstrual irregularities compared to the normal/healthy population. The risk was higher in the older age group (greater than 30 years old) and those on cyclophosphamide therapy, especially those with a cumulative dose of more than 10 g. Sustained amenorrhoea was the commonest irregularity and a majority of them had confirmed premature menopause. Singapore Medical Association 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/17142/1/Prevalence_and_Risk_Factors_for_Menstrual.pdf Mohd Shah, Azarisman Shah and NNA, Fatnoon and D, Zainal (2008) Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients. Singapore Medical Journal, 49(5) (413). ISSN 0037-5675 http://smj.sma.org.sg/smjcurrent.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Mohd Shah, Azarisman Shah NNA, Fatnoon D, Zainal Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients
description	Introduction: This study aims to determine the prevalence and the types of menstrual disorders among patients with systemic lupus erythematosus (SLE) and to identify factors that influence their development. Methods: 61 patients with SLE were enrolled into a cross-sectional, observational study at the medical outpatient clinic, Hospital Universiti Sains Malaysia. A total of 120 healthy women were selected randomly to act as the control group. A questionnaire was administered, vital signs were recorded, and blood was evaluated for routine investigations. A review of past medical records was also undertaken. Results: The mean age and standard deviation for the study group was 33.23 +/- 10.96 years, the majority being ethnic Malays. 75 percent had a severe SLE disease activity index score on initial presentation, and 59 percent were on cyclophosphamide. 49 percent of the study population had menstrual irregularities, of which 60 percent had sustained amenorrhoea. Nine patients with sustained amenorrhoea had hormonal assays, which confirmed the diagnosis of premature menopause. Conclusion: This study showed that SLE patients had a higher risk of developing menstrual irregularities compared to the normal/healthy population. The risk was higher in the older age group (greater than 30 years old) and those on cyclophosphamide therapy, especially those with a cumulative dose of more than 10 g. Sustained amenorrhoea was the commonest irregularity and a majority of them had confirmed premature menopause.
format	Article
author	Mohd Shah, Azarisman Shah NNA, Fatnoon D, Zainal
author_facet	Mohd Shah, Azarisman Shah NNA, Fatnoon D, Zainal
author_sort	Mohd Shah, Azarisman Shah
title	Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients
title_short	Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients
title_full	Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients
title_fullStr	Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients
title_full_unstemmed	Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients
title_sort	prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients
publisher	Singapore Medical Association
publishDate	2008
url	http://irep.iium.edu.my/17142/ http://irep.iium.edu.my/17142/ http://irep.iium.edu.my/17142/1/Prevalence_and_Risk_Factors_for_Menstrual.pdf
first_indexed	2023-09-18T20:25:57Z
last_indexed	2023-09-18T20:25:57Z
_version_	1777408417402454016

Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients

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