Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea

Multidrug resistance Staphylococcus aureus (MRSA) is a major threat to health sector worldwide due to their prevalence, intrinsic virulence & limited therapeutic means. MRSA infections complicate therapy and could double the mortality rate amongst the immuno-compromised, the elderly, infants and...

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Main Authors:	Mat Amin, Nor Datiakma, Alias, Noraliza, Syed Osman Idid, Syed Zahir Idid, Mansor, Marzalina, Mohd. Salleh, Hamzah, Jalali, Saeid Reza Doust, Mohtar, Mastura
Format:	Conference or Workshop Item
Language:	English
Published:	2010
Subjects:	QR Microbiology
Online Access:	http://irep.iium.edu.my/17070/ http://irep.iium.edu.my/17070/ http://irep.iium.edu.my/17070/1/anti_multidrug.pdf

id	iium-17070
recordtype	eprints
spelling	iium-170702012-02-01T11:06:29Z http://irep.iium.edu.my/17070/ Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea Mat Amin, Nor Datiakma Alias, Noraliza Syed Osman Idid, Syed Zahir Idid Mansor, Marzalina Mohd. Salleh, Hamzah Jalali, Saeid Reza Doust Mohtar, Mastura QR Microbiology Multidrug resistance Staphylococcus aureus (MRSA) is a major threat to health sector worldwide due to their prevalence, intrinsic virulence & limited therapeutic means. MRSA infections complicate therapy and could double the mortality rate amongst the immuno-compromised, the elderly, infants and patients at the surgical and burnt units. The cost to treat hospitalized patients with MRSA infections is estimated to be between $3.2 billion to $4.2 billion per-annum. The emergence of community-acquired MRSA (CA-MRSA) and vancomycin-resistant (VRE) globally indicates that our current treatment for MRSA infection is getting more complicated and needs replenishment. Therefore, the search for an alternative anti-MRSA agent is very important to cater to this issue. Our research discovered the potential plant derived anti-MRSA agent derived from crude extract from leaves of Macaranga gigantea. M. gigantea is rich in alkaloids and tannins and traditionally used among the aboriginal tribes in Borneo to treat fungal infection and stomach aches. In this study, ethanol extract of M. gigantea was found active in inhibiting and killing MRSA at 0.313 mg/ml (MIC and MBC) with extraction recovery yield is approximately 11.1% (W/W). Instead of anti-MRSA potential, the extract of M. gigantea also found active against bacteria Eschericia col (MIC and MBC: 0.156 mg/ml) and fungus strain tryptophyton rubrum (MIC and MBC: 0.613 mg/ml). Acute oral toxicity studies adapting the OECD Guideline was conducted for 7 consecutive days on mice. The study conducted demonstrates that the median Lethal Dose (LD50) of the extract is more than 5g/kg of bodyweight and considered very low toxicity as compared with Vancomycin (LD50: 5g/kg of bodyweight) and table salt (LD50: 4g/kg of bodyweight). This extract is applicable in the sanitary industry, for example it can be useful in medical vicinities, hotels, for home usage, as well as food hygiene aspects where is a high risk of contamination by MRSA. 2010 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/17070/1/anti_multidrug.pdf Mat Amin, Nor Datiakma and Alias, Noraliza and Syed Osman Idid, Syed Zahir Idid and Mansor, Marzalina and Mohd. Salleh, Hamzah and Jalali, Saeid Reza Doust and Mohtar, Mastura (2010) Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea. In: 3rd International Conference on Advancement in Science and Technology (iCAST) 2010, 27-29 November 2010, Vistana Hotel, Kuantan, Pahang. http://www.iium.edu.my/icast/2010/index.php?option=com_content&view=article&id=14&Itemid=17
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QR Microbiology
spellingShingle	QR Microbiology Mat Amin, Nor Datiakma Alias, Noraliza Syed Osman Idid, Syed Zahir Idid Mansor, Marzalina Mohd. Salleh, Hamzah Jalali, Saeid Reza Doust Mohtar, Mastura Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea
description	Multidrug resistance Staphylococcus aureus (MRSA) is a major threat to health sector worldwide due to their prevalence, intrinsic virulence & limited therapeutic means. MRSA infections complicate therapy and could double the mortality rate amongst the immuno-compromised, the elderly, infants and patients at the surgical and burnt units. The cost to treat hospitalized patients with MRSA infections is estimated to be between $3.2 billion to $4.2 billion per-annum. The emergence of community-acquired MRSA (CA-MRSA) and vancomycin-resistant (VRE) globally indicates that our current treatment for MRSA infection is getting more complicated and needs replenishment. Therefore, the search for an alternative anti-MRSA agent is very important to cater to this issue. Our research discovered the potential plant derived anti-MRSA agent derived from crude extract from leaves of Macaranga gigantea. M. gigantea is rich in alkaloids and tannins and traditionally used among the aboriginal tribes in Borneo to treat fungal infection and stomach aches. In this study, ethanol extract of M. gigantea was found active in inhibiting and killing MRSA at 0.313 mg/ml (MIC and MBC) with extraction recovery yield is approximately 11.1% (W/W). Instead of anti-MRSA potential, the extract of M. gigantea also found active against bacteria Eschericia col (MIC and MBC: 0.156 mg/ml) and fungus strain tryptophyton rubrum (MIC and MBC: 0.613 mg/ml). Acute oral toxicity studies adapting the OECD Guideline was conducted for 7 consecutive days on mice. The study conducted demonstrates that the median Lethal Dose (LD50) of the extract is more than 5g/kg of bodyweight and considered very low toxicity as compared with Vancomycin (LD50: 5g/kg of bodyweight) and table salt (LD50: 4g/kg of bodyweight). This extract is applicable in the sanitary industry, for example it can be useful in medical vicinities, hotels, for home usage, as well as food hygiene aspects where is a high risk of contamination by MRSA.
format	Conference or Workshop Item
author	Mat Amin, Nor Datiakma Alias, Noraliza Syed Osman Idid, Syed Zahir Idid Mansor, Marzalina Mohd. Salleh, Hamzah Jalali, Saeid Reza Doust Mohtar, Mastura
author_facet	Mat Amin, Nor Datiakma Alias, Noraliza Syed Osman Idid, Syed Zahir Idid Mansor, Marzalina Mohd. Salleh, Hamzah Jalali, Saeid Reza Doust Mohtar, Mastura
author_sort	Mat Amin, Nor Datiakma
title	Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea
title_short	Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea
title_full	Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea
title_fullStr	Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea
title_full_unstemmed	Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea
title_sort	anti-multidrug resistance staphylococcus aureus (mrsa) potential of macaranga gigantea
publishDate	2010
url	http://irep.iium.edu.my/17070/ http://irep.iium.edu.my/17070/ http://irep.iium.edu.my/17070/1/anti_multidrug.pdf
first_indexed	2023-09-18T20:25:53Z
last_indexed	2023-09-18T20:25:53Z
_version_	1777408412765650944

Anti-multidrug resistance Staphylococcus aureus (MRSA) potential of Macaranga gigantea

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