Calophyllum canum : antibacterial and anticancer plant

Human have used plants as a source of medicine throughout the world since time immemorial. Today there are at least 120 distinct chemical substances derived from plants that are considered as important drugs currently in use in one or more countries in the world. In particular, 60% drugs currently i...

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Main Authors:	Darnis, Deny Susanti, Bakhtiar, M. Taher, Syed Osman Idid, Syed Zahir Idid, Ahmad, Hanad, Sheikh Mohamed , Hassan Ibrahim, Suleiman Ngoto, Shahida
Format:	Conference or Workshop Item
Language:	English
Published:	2010
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/16560/ http://irep.iium.edu.my/16560/ http://irep.iium.edu.my/16560/1/2010_IRIIE_Kamarul_et_al_Aromatic.pdf

id	iium-16560
recordtype	eprints
spelling	iium-165602014-12-09T01:38:00Z http://irep.iium.edu.my/16560/ Calophyllum canum : antibacterial and anticancer plant Darnis, Deny Susanti Bakhtiar, M. Taher Syed Osman Idid, Syed Zahir Idid Ahmad, Hanad Sheikh Mohamed , Hassan Ibrahim Suleiman Ngoto, Shahida Q Science (General) Human have used plants as a source of medicine throughout the world since time immemorial. Today there are at least 120 distinct chemical substances derived from plants that are considered as important drugs currently in use in one or more countries in the world. In particular, 60% drugs currently in clinical use for treatment of cancer were found to be of natural origin. Calophyllum canum is a large tree which grows in South East Asia and which is popular for its timber. This plant belongs to the family Guttiferae; a family that boasts species which are rich in bioactive phytochemicals. Some species are believed to having medicinal values and are used against several diseases including anti-inflammatory, anti infectious, astringent and antipyretic. We have successfully isolated two compounds from the methanol extract of Calophyllum canum stembarks that active inhibit the growth of Staphylococcus aureus (ATCC 29213 and ATCC 25923). The cytotoxic study on the extracts revealed that the n-hexane extract had the strongest antiproliferation activity, followed by the methanol extract. n-hexane strongly inhibited the growth of TE1 and MCF7 cell lines. IC50 for n-hexane and methanol extract activity on the A549 cell line was found to be 27.96 μg/mL and 78.9 μg/mL respectively.The compounds (CE0 - CE5) isolated from ethyl acetate extract of C. canum are active to inhibit cell proliferation of human cervix adenocarcinoma cells. 2010 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/16560/1/2010_IRIIE_Kamarul_et_al_Aromatic.pdf Darnis, Deny Susanti and Bakhtiar, M. Taher and Syed Osman Idid, Syed Zahir Idid and Ahmad, Hanad and Sheikh Mohamed , Hassan Ibrahim and Suleiman Ngoto, Shahida (2010) Calophyllum canum : antibacterial and anticancer plant. In: IIUM Research, Innovation & Invention Exhibition (IRIIE 2010), 26 - 27 January 2010, Kuala Lumpur. (Unpublished) http://www.iium.edu.my/irie/10/sub10/author/list_p.php
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Darnis, Deny Susanti Bakhtiar, M. Taher Syed Osman Idid, Syed Zahir Idid Ahmad, Hanad Sheikh Mohamed , Hassan Ibrahim Suleiman Ngoto, Shahida Calophyllum canum : antibacterial and anticancer plant
description	Human have used plants as a source of medicine throughout the world since time immemorial. Today there are at least 120 distinct chemical substances derived from plants that are considered as important drugs currently in use in one or more countries in the world. In particular, 60% drugs currently in clinical use for treatment of cancer were found to be of natural origin. Calophyllum canum is a large tree which grows in South East Asia and which is popular for its timber. This plant belongs to the family Guttiferae; a family that boasts species which are rich in bioactive phytochemicals. Some species are believed to having medicinal values and are used against several diseases including anti-inflammatory, anti infectious, astringent and antipyretic. We have successfully isolated two compounds from the methanol extract of Calophyllum canum stembarks that active inhibit the growth of Staphylococcus aureus (ATCC 29213 and ATCC 25923). The cytotoxic study on the extracts revealed that the n-hexane extract had the strongest antiproliferation activity, followed by the methanol extract. n-hexane strongly inhibited the growth of TE1 and MCF7 cell lines. IC50 for n-hexane and methanol extract activity on the A549 cell line was found to be 27.96 μg/mL and 78.9 μg/mL respectively.The compounds (CE0 - CE5) isolated from ethyl acetate extract of C. canum are active to inhibit cell proliferation of human cervix adenocarcinoma cells.
format	Conference or Workshop Item
author	Darnis, Deny Susanti Bakhtiar, M. Taher Syed Osman Idid, Syed Zahir Idid Ahmad, Hanad Sheikh Mohamed , Hassan Ibrahim Suleiman Ngoto, Shahida
author_facet	Darnis, Deny Susanti Bakhtiar, M. Taher Syed Osman Idid, Syed Zahir Idid Ahmad, Hanad Sheikh Mohamed , Hassan Ibrahim Suleiman Ngoto, Shahida
author_sort	Darnis, Deny Susanti
title	Calophyllum canum : antibacterial and anticancer plant
title_short	Calophyllum canum : antibacterial and anticancer plant
title_full	Calophyllum canum : antibacterial and anticancer plant
title_fullStr	Calophyllum canum : antibacterial and anticancer plant
title_full_unstemmed	Calophyllum canum : antibacterial and anticancer plant
title_sort	calophyllum canum : antibacterial and anticancer plant
publishDate	2010
url	http://irep.iium.edu.my/16560/ http://irep.iium.edu.my/16560/ http://irep.iium.edu.my/16560/1/2010_IRIIE_Kamarul_et_al_Aromatic.pdf
first_indexed	2023-09-18T20:25:20Z
last_indexed	2023-09-18T20:25:20Z
_version_	1777408378769768448

Calophyllum canum : antibacterial and anticancer plant

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