Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket

Periodontitis is a chronic inflammatory disease, elicited by a complex mixture of anaerobic, Gram-negative bacteria that result in the destruction of the supporting structures of the dentition (Pihlstrom et al, 2005). This disease affects the majority of population (Brown et al, 1996) and the peri...

Full description

Bibliographic Details
Main Authors:	Al-Bayati, Lina, Kamil, Wisam, Habashnah, Rola, Abbood, Lina H.
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RK Dentistry
Online Access:	http://irep.iium.edu.my/16081/ http://irep.iium.edu.my/16081/1/IIUM_Research_Inv..pdf

id	iium-16081
recordtype	eprints
spelling	iium-160812014-03-20T02:39:39Z http://irep.iium.edu.my/16081/ Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket Al-Bayati, Lina Kamil, Wisam Habashnah, Rola Abbood, Lina H. RK Dentistry Periodontitis is a chronic inflammatory disease, elicited by a complex mixture of anaerobic, Gram-negative bacteria that result in the destruction of the supporting structures of the dentition (Pihlstrom et al, 2005). This disease affects the majority of population (Brown et al, 1996) and the periodontal tooth mortality was reported by Ong, 1998 to be associated with the loss of periodontal attachment. C-reactive protein, as an acute-phase reactant, currently being labelled as a possible risk indicator for future cardiac events, and it is elevated in periodontitis patients compared to controls (Ebersole et al, 1997). Despite the fact for effectiveness of periodontal treatment in modifying the level of serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6) (Ebersole et al., 1997, Mattila et al., 2002), incomplete or inadequate treatment of extensive periodontal disease will not be expected to have a significant impact on systemic mediators (Ioannidou et al., 2006). The aim of this study was to explore the outcomes of periodontal therapy in terms of changes in C-reactive protein (CRP) and its effect on the depth of pathological periodontal defect. Following protocol review and approval by Institutional Review Board of Jordan university of science and technology, a total of fifty five periodontitis patients randomly distributed into either a treatment group (37 patients) received non-surgical periodontal therapy with intensive oral hygiene nstructions and repeated therapy course for residual bleeding periodontal pockets or control group (18 patients) received delayed periodontal treatment after completion of clinical trial evaluation. Medical history, demographic data and clinical periodontal parameters and C-reactive protein were collected at baseline and three months at reassessment appointments. The results showed statistically significant improvements for all periodontal clinical parameters, and significant reduction of hs-CRP levels (p=0.003) after the treatment regime within the tested treatment group compared to control patients, and there was a significant positive correlation (p=0.006, r=0.411) between elevated serum levels of CRP and deep pathological periodontal pockets. 2011-01-09 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/16081/1/IIUM_Research_Inv..pdf Al-Bayati, Lina and Kamil, Wisam and Habashnah, Rola and Abbood, Lina H. (2011) Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket. In: IIUM Research, Invention and Innovation Exhibition 2011, 9-10 February 2011, IIUM Gombak.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RK Dentistry
spellingShingle	RK Dentistry Al-Bayati, Lina Kamil, Wisam Habashnah, Rola Abbood, Lina H. Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket
description	Periodontitis is a chronic inflammatory disease, elicited by a complex mixture of anaerobic, Gram-negative bacteria that result in the destruction of the supporting structures of the dentition (Pihlstrom et al, 2005). This disease affects the majority of population (Brown et al, 1996) and the periodontal tooth mortality was reported by Ong, 1998 to be associated with the loss of periodontal attachment. C-reactive protein, as an acute-phase reactant, currently being labelled as a possible risk indicator for future cardiac events, and it is elevated in periodontitis patients compared to controls (Ebersole et al, 1997). Despite the fact for effectiveness of periodontal treatment in modifying the level of serum levels of C-reactive protein (CRP) and interleukin-6 (IL-6) (Ebersole et al., 1997, Mattila et al., 2002), incomplete or inadequate treatment of extensive periodontal disease will not be expected to have a significant impact on systemic mediators (Ioannidou et al., 2006). The aim of this study was to explore the outcomes of periodontal therapy in terms of changes in C-reactive protein (CRP) and its effect on the depth of pathological periodontal defect. Following protocol review and approval by Institutional Review Board of Jordan university of science and technology, a total of fifty five periodontitis patients randomly distributed into either a treatment group (37 patients) received non-surgical periodontal therapy with intensive oral hygiene nstructions and repeated therapy course for residual bleeding periodontal pockets or control group (18 patients) received delayed periodontal treatment after completion of clinical trial evaluation. Medical history, demographic data and clinical periodontal parameters and C-reactive protein were collected at baseline and three months at reassessment appointments. The results showed statistically significant improvements for all periodontal clinical parameters, and significant reduction of hs-CRP levels (p=0.003) after the treatment regime within the tested treatment group compared to control patients, and there was a significant positive correlation (p=0.006, r=0.411) between elevated serum levels of CRP and deep pathological periodontal pockets.
format	Conference or Workshop Item
author	Al-Bayati, Lina Kamil, Wisam Habashnah, Rola Abbood, Lina H.
author_facet	Al-Bayati, Lina Kamil, Wisam Habashnah, Rola Abbood, Lina H.
author_sort	Al-Bayati, Lina
title	Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket
title_short	Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket
title_full	Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket
title_fullStr	Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket
title_full_unstemmed	Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket
title_sort	changes in high sensitivity serum crp under periodontal therapy and its association with the depth of pathological periodontal pocket
publishDate	2011
url	http://irep.iium.edu.my/16081/ http://irep.iium.edu.my/16081/1/IIUM_Research_Inv..pdf
first_indexed	2023-09-18T20:24:57Z
last_indexed	2023-09-18T20:24:57Z
_version_	1777408354752135168

Changes in high sensitivity serum CRP under periodontal therapy and its association with the depth of pathological periodontal pocket

Similar Items