Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides

S. pyogenes secrete a large array of molecules that might contribute to resistance against the human’s antimicrobial peptides (AMPs). Some of these are anchored in the cell-wall by enzymes called sortases and others are released from the cell after secretion. Two released proteins that have previous...

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Main Authors:	Shahdan, Intan Azura, Hall, Judith, Kehoe, Mike
Format:	Conference or Workshop Item
Language:	English
Published:	2010
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/15937/ http://irep.iium.edu.my/15937/ http://irep.iium.edu.my/15937/1/2010_IRIIE_Kamarul_et_al_Aromatic.pdf

id	iium-15937
recordtype	eprints
spelling	iium-159372012-01-30T03:09:00Z http://irep.iium.edu.my/15937/ Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides Shahdan, Intan Azura Hall, Judith Kehoe, Mike Q Science (General) S. pyogenes secrete a large array of molecules that might contribute to resistance against the human’s antimicrobial peptides (AMPs). Some of these are anchored in the cell-wall by enzymes called sortases and others are released from the cell after secretion. Two released proteins that have previously been reported to inhibit bactericidal effect of the AMPs are streptococcal inhibitor of complement (SIC) and cysteine protease, SpeB. In this study, several S. pyogenes strain SF370 deletion mutants were compared to the parent wild-type strain for resistance to the AMPs LL-37 and LEAP-2. We found that released proteins SIC and SpeB contribute to streptococcal resistance against LL-37; and cell wallanchored proteins by sortases SrtA and SrtC are also important in streptococcal resistance against LL-37 but not with LEAP-2. Our study conclude that LL-37 kills S. pyogenes strain SF370 better than LEAP-2 peptide. 2010 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/15937/1/2010_IRIIE_Kamarul_et_al_Aromatic.pdf Shahdan, Intan Azura and Hall, Judith and Kehoe, Mike (2010) Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides. In: IIUM Research, Innovation & Invention Exhibition (IRIIE 2010), 26 - 27 January 2010, Kuala Lumpur. http://www.iium.edu.my/irie/10/info/Programme_Book%20Part_2.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Shahdan, Intan Azura Hall, Judith Kehoe, Mike Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides
description	S. pyogenes secrete a large array of molecules that might contribute to resistance against the human’s antimicrobial peptides (AMPs). Some of these are anchored in the cell-wall by enzymes called sortases and others are released from the cell after secretion. Two released proteins that have previously been reported to inhibit bactericidal effect of the AMPs are streptococcal inhibitor of complement (SIC) and cysteine protease, SpeB. In this study, several S. pyogenes strain SF370 deletion mutants were compared to the parent wild-type strain for resistance to the AMPs LL-37 and LEAP-2. We found that released proteins SIC and SpeB contribute to streptococcal resistance against LL-37; and cell wallanchored proteins by sortases SrtA and SrtC are also important in streptococcal resistance against LL-37 but not with LEAP-2. Our study conclude that LL-37 kills S. pyogenes strain SF370 better than LEAP-2 peptide.
format	Conference or Workshop Item
author	Shahdan, Intan Azura Hall, Judith Kehoe, Mike
author_facet	Shahdan, Intan Azura Hall, Judith Kehoe, Mike
author_sort	Shahdan, Intan Azura
title	Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides
title_short	Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides
title_full	Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides
title_fullStr	Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides
title_full_unstemmed	Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides
title_sort	streptococcus pyogenes proteins involved in resistance to antimicrobial peptides
publishDate	2010
url	http://irep.iium.edu.my/15937/ http://irep.iium.edu.my/15937/ http://irep.iium.edu.my/15937/1/2010_IRIIE_Kamarul_et_al_Aromatic.pdf
first_indexed	2023-09-18T20:24:50Z
last_indexed	2023-09-18T20:24:50Z
_version_	1777408347251671040

Streptococcus pyogenes proteins involved in resistance to antimicrobial peptides

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