Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.

Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.

Successive extraction of the dried leaves of Melastoma malabathricum, followed by purification using repeated chromatographic techniques, yielded six compounds, including two amides, auranamide and patriscabratine, a triterpene, a-amyrin, and three flavonoids, quercitrin, quercetin and kaempferol...

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Main Authors: M. Sirat, Hasnah, Darnis, Deny Susanti, Ahmad, Farediah, Takayama, Hiromitsu, Kitajima, Mariko
Format: Article
Language:English
Published: Springer 2010
Subjects:
Q Science (General)
Online Access:http://irep.iium.edu.my/1570/
http://irep.iium.edu.my/1570/
http://irep.iium.edu.my/1570/
http://irep.iium.edu.my/1570/1/Journal_Natural_Medicine._%282010%29_64492%E2%80%93495.pdf
id iium-1570
recordtype eprints
spelling iium-15702011-12-28T06:51:42Z http://irep.iium.edu.my/1570/ Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L. M. Sirat, Hasnah Darnis, Deny Susanti Ahmad, Farediah Takayama, Hiromitsu Kitajima, Mariko Q Science (General) Successive extraction of the dried leaves of Melastoma malabathricum, followed by purification using repeated chromatographic techniques, yielded six compounds, including two amides, auranamide and patriscabratine, a triterpene, a-amyrin, and three flavonoids, quercitrin, quercetin and kaempferol-3-O-(200,600-di-O-p-trans-coumaroyl)-b-glucoside. Their structures were elucidated by spectroscopic means and also by direct comparison of their spectroscopic data with respective published data. These three phenolic constituents were found to be active as free radical scavengers, with quercetin being the strongest radical scavenger, having an IC50 value of 0.69 lM in the UV method. Quercitrin and kaempferol-3-O-(200,600-di-O-ptrans- coumaroyl)-b-glucoside showed moderate radical scavenging, with IC50 values of 74.1 and 108.8 lM,respectively. Springer 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/1570/1/Journal_Natural_Medicine._%282010%29_64492%E2%80%93495.pdf M. Sirat, Hasnah and Darnis, Deny Susanti and Ahmad, Farediah and Takayama, Hiromitsu and Kitajima, Mariko (2010) Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L. Journal of Natural Medicines, 64 (4). pp. 492-495. ISSN 1340-3443 http://dx.doi.org/10.1007/s11418-010-0431-8 doi:10.1007/s11418-010-0431-8
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic Q Science (General)
spellingShingle Q Science (General)
M. Sirat, Hasnah
Darnis, Deny Susanti
Ahmad, Farediah
Takayama, Hiromitsu
Kitajima, Mariko
Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.
description Successive extraction of the dried leaves of Melastoma malabathricum, followed by purification using repeated chromatographic techniques, yielded six compounds, including two amides, auranamide and patriscabratine, a triterpene, a-amyrin, and three flavonoids, quercitrin, quercetin and kaempferol-3-O-(200,600-di-O-p-trans-coumaroyl)-b-glucoside. Their structures were elucidated by spectroscopic means and also by direct comparison of their spectroscopic data with respective published data. These three phenolic constituents were found to be active as free radical scavengers, with quercetin being the strongest radical scavenger, having an IC50 value of 0.69 lM in the UV method. Quercitrin and kaempferol-3-O-(200,600-di-O-ptrans- coumaroyl)-b-glucoside showed moderate radical scavenging, with IC50 values of 74.1 and 108.8 lM,respectively.
format Article
author M. Sirat, Hasnah
Darnis, Deny Susanti
Ahmad, Farediah
Takayama, Hiromitsu
Kitajima, Mariko
author_facet M. Sirat, Hasnah
Darnis, Deny Susanti
Ahmad, Farediah
Takayama, Hiromitsu
Kitajima, Mariko
author_sort M. Sirat, Hasnah
title Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.
title_short Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.
title_full Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.
title_fullStr Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.
title_full_unstemmed Amides, triterpene and flavonoids from the leaves of Melastoma malabathricum L.
title_sort amides, triterpene and flavonoids from the leaves of melastoma malabathricum l.
publisher Springer
publishDate 2010
url http://irep.iium.edu.my/1570/
http://irep.iium.edu.my/1570/
http://irep.iium.edu.my/1570/
http://irep.iium.edu.my/1570/1/Journal_Natural_Medicine._%282010%29_64492%E2%80%93495.pdf
first_indexed 2023-09-18T20:08:56Z
last_indexed 2023-09-18T20:08:56Z
_version_ 1777407347191185408

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