Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier

One of the most commonly used dosage form in drug delivery systems is emulsion. It is useful for the delivery of drugs with poor water solubility, which do not formulate well in aqueous solutions. An emulsion is a dispersed system containing at least two immiscible liquid phases, typically a lipid...

Full description

Bibliographic Details
Main Authors:	Ahmad, Kausar, Mohd Hassan, Norazian, Bakhtiar, M. Taher, Hadi, Janan Nima
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	QD Chemistry RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/15214/ http://irep.iium.edu.my/15214/1/Purple_Science_Engineering_and_Technology_IRIIE2011_ID590_SAROMATICUM.pdf

id	iium-15214
recordtype	eprints
spelling	iium-152142014-12-09T01:35:33Z http://irep.iium.edu.my/15214/ Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier Ahmad, Kausar Mohd Hassan, Norazian Bakhtiar, M. Taher Hadi, Janan Nima QD Chemistry RS Pharmacy and materia medica One of the most commonly used dosage form in drug delivery systems is emulsion. It is useful for the delivery of drugs with poor water solubility, which do not formulate well in aqueous solutions. An emulsion is a dispersed system containing at least two immiscible liquid phases, typically a lipid phase and an aqueous phase. Emulsions may be either oil-in-water (o/w) or water-in-oil (w/o) emulsions. In the oil-in-water emulsion, oil droplets of the lipid phase are dispersed throughout the aqueous phase, while in water-in-oil emulsion, the aqueous phase is dispersed as droplets throughout the lipid phase. In addition, multiple emulsions such as oil-in-water-in-oil or water-in-oil-in-water emulsions can be prepared. The objective of this research is to determine the emulsion formation using various crude extracts of Syzygium aromaticum, commonly known as clove. The extracts were obtained by macerating in four types of solvents and followed by drying. The palm olein-water interfacial tension containing extracts from water and ethanol/water (1:1) decreased to 21-22 mN/m. Palm olein-in-water emulsions were prepared by homogenizing palm olein and distilled water in the presence of 10% crude extracts at 11,500 rpm for 20 minutes at 24 ±1°C. Tween® 20 was used as control. The extent of phase separation and changes in particle size distribution were monitored. The most stable emulsions can be obtained using the aqueous and ethanol/aqueous extracts (1:1). There was no phase separation and no significant change in the particle size within six months. Emulsion stability was poor when extracts from isopropanol/chloroform or ethanol/water (9:1) were used. 2011 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/15214/1/Purple_Science_Engineering_and_Technology_IRIIE2011_ID590_SAROMATICUM.pdf Ahmad, Kausar and Mohd Hassan, Norazian and Bakhtiar, M. Taher and Hadi, Janan Nima (2011) Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2011, 9-10 February 2011, Cultural Activity Centre (CAC) and KAED Gallery IIUM. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry RS Pharmacy and materia medica
spellingShingle	QD Chemistry RS Pharmacy and materia medica Ahmad, Kausar Mohd Hassan, Norazian Bakhtiar, M. Taher Hadi, Janan Nima Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier
description	One of the most commonly used dosage form in drug delivery systems is emulsion. It is useful for the delivery of drugs with poor water solubility, which do not formulate well in aqueous solutions. An emulsion is a dispersed system containing at least two immiscible liquid phases, typically a lipid phase and an aqueous phase. Emulsions may be either oil-in-water (o/w) or water-in-oil (w/o) emulsions. In the oil-in-water emulsion, oil droplets of the lipid phase are dispersed throughout the aqueous phase, while in water-in-oil emulsion, the aqueous phase is dispersed as droplets throughout the lipid phase. In addition, multiple emulsions such as oil-in-water-in-oil or water-in-oil-in-water emulsions can be prepared. The objective of this research is to determine the emulsion formation using various crude extracts of Syzygium aromaticum, commonly known as clove. The extracts were obtained by macerating in four types of solvents and followed by drying. The palm olein-water interfacial tension containing extracts from water and ethanol/water (1:1) decreased to 21-22 mN/m. Palm olein-in-water emulsions were prepared by homogenizing palm olein and distilled water in the presence of 10% crude extracts at 11,500 rpm for 20 minutes at 24 ±1°C. Tween® 20 was used as control. The extent of phase separation and changes in particle size distribution were monitored. The most stable emulsions can be obtained using the aqueous and ethanol/aqueous extracts (1:1). There was no phase separation and no significant change in the particle size within six months. Emulsion stability was poor when extracts from isopropanol/chloroform or ethanol/water (9:1) were used.
format	Conference or Workshop Item
author	Ahmad, Kausar Mohd Hassan, Norazian Bakhtiar, M. Taher Hadi, Janan Nima
author_facet	Ahmad, Kausar Mohd Hassan, Norazian Bakhtiar, M. Taher Hadi, Janan Nima
author_sort	Ahmad, Kausar
title	Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier
title_short	Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier
title_full	Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier
title_fullStr	Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier
title_full_unstemmed	Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier
title_sort	palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier
publishDate	2011
url	http://irep.iium.edu.my/15214/ http://irep.iium.edu.my/15214/1/Purple_Science_Engineering_and_Technology_IRIIE2011_ID590_SAROMATICUM.pdf
first_indexed	2023-09-18T20:24:16Z
last_indexed	2023-09-18T20:24:16Z
_version_	1777408311460626432

Palm olein emulsion formation using crude extract of syzygium aromaticum as emulsifier

Similar Items