Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone

Background: Healing of all damaged tissues including skin wounds have an identical pattern and depends on numerous intrinsic and extrinsic factors, one of these factors is cortisone hormone. Aim of study: The present study was designed to show the effect of dexamethasone on skin wound healing....

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Main Authors:	Kashmola, Muhanad Ali Hamdon, Mustafa, Nazih Shaban, Mustafa Al-Ahmad, Basma Ezzat, Al-Ani, Imad Matloub Dally
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/14528/ http://irep.iium.edu.my/14528/ http://irep.iium.edu.my/14528/1/Histopathological_evaluation_of_skin.pdf

id	iium-14528
recordtype	eprints
spelling	iium-145282015-12-18T03:06:20Z http://irep.iium.edu.my/14528/ Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone Kashmola, Muhanad Ali Hamdon Mustafa, Nazih Shaban Mustafa Al-Ahmad, Basma Ezzat Al-Ani, Imad Matloub Dally R Medicine (General) Background: Healing of all damaged tissues including skin wounds have an identical pattern and depends on numerous intrinsic and extrinsic factors, one of these factors is cortisone hormone. Aim of study: The present study was designed to show the effect of dexamethasone on skin wound healing. Materials and methods: Twelve rabbits were used, experimental group (7 rabbits) administrated 4 mg dexamethasone ten days prior to skin incision and control group (5 rabbits) had got skin incision. Biopsies were taken from two groups for histopathological evaluation. Results: control group shows proper wound healing includes epithelial growth migration that brought the wound edges to be close. Granulation tissue underneath the epithelium show to fill the incision gap represented by collagen fibers and fibroblast cells. The experimental group shows failure of epithelial wound edges to close and to be approximately in contact with absence of rete ridges. The main bulk tissue filled the incision gap is thick granulation tissue. Inflammatory cell with congested blood vessels can be detected. Conclusion: Prolonged use of dexamethasone or misuse of this drug impaired wound healing. 2011 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/14528/1/Histopathological_evaluation_of_skin.pdf Kashmola, Muhanad Ali Hamdon and Mustafa, Nazih Shaban and Mustafa Al-Ahmad, Basma Ezzat and Al-Ani, Imad Matloub Dally (2011) Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone. In: 20th Scientific Conference of Microscopy Society of Malaysia & 21st Annual General Meeting, 20-22 Dec 2011, Permaisuri Resort, Port Dickson. http://online.nuclearmalaysia.gov.my/sems/emsm2011/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Kashmola, Muhanad Ali Hamdon Mustafa, Nazih Shaban Mustafa Al-Ahmad, Basma Ezzat Al-Ani, Imad Matloub Dally Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone
description	Background: Healing of all damaged tissues including skin wounds have an identical pattern and depends on numerous intrinsic and extrinsic factors, one of these factors is cortisone hormone. Aim of study: The present study was designed to show the effect of dexamethasone on skin wound healing. Materials and methods: Twelve rabbits were used, experimental group (7 rabbits) administrated 4 mg dexamethasone ten days prior to skin incision and control group (5 rabbits) had got skin incision. Biopsies were taken from two groups for histopathological evaluation. Results: control group shows proper wound healing includes epithelial growth migration that brought the wound edges to be close. Granulation tissue underneath the epithelium show to fill the incision gap represented by collagen fibers and fibroblast cells. The experimental group shows failure of epithelial wound edges to close and to be approximately in contact with absence of rete ridges. The main bulk tissue filled the incision gap is thick granulation tissue. Inflammatory cell with congested blood vessels can be detected. Conclusion: Prolonged use of dexamethasone or misuse of this drug impaired wound healing.
format	Conference or Workshop Item
author	Kashmola, Muhanad Ali Hamdon Mustafa, Nazih Shaban Mustafa Al-Ahmad, Basma Ezzat Al-Ani, Imad Matloub Dally
author_facet	Kashmola, Muhanad Ali Hamdon Mustafa, Nazih Shaban Mustafa Al-Ahmad, Basma Ezzat Al-Ani, Imad Matloub Dally
author_sort	Kashmola, Muhanad Ali Hamdon
title	Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone
title_short	Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone
title_full	Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone
title_fullStr	Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone
title_full_unstemmed	Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone
title_sort	histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone
publishDate	2011
url	http://irep.iium.edu.my/14528/ http://irep.iium.edu.my/14528/ http://irep.iium.edu.my/14528/1/Histopathological_evaluation_of_skin.pdf
first_indexed	2023-09-18T20:23:42Z
last_indexed	2023-09-18T20:23:42Z
_version_	1777408275975766016

Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone

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