Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius

In this study, a three dimensional (3D) model of the third ventricle and aqueduct of Sylvius derived from MRI scans was constructed by using Computational Fluid Dynamics (CFD) modeling. Cerebrospinal fluid(CSF) can be modeled as a Newtonian Fluid and its flow through the region of interest (ROI) was...

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Main Authors:	Hadzri, Edi Azali, Abdul Ghani, Ahmad Lufti, Shamsuddin, Amir Hamzah, Osman, Kahar, Abdul Kadir, Mohammed Rafiq, Abd. Aziz, Azian
Format:	Article
Language:	English
Published:	IIUM Press 2011
Subjects:	TA164 Bioengineering
Online Access:	http://irep.iium.edu.my/14201/ http://irep.iium.edu.my/14201/1/Computational_Ix_on_CSF_Flow_Analysis._2011.pdf

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recordtype	eprints
spelling	iium-142012013-04-26T10:41:20Z http://irep.iium.edu.my/14201/ Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius Hadzri, Edi Azali Abdul Ghani, Ahmad Lufti Shamsuddin, Amir Hamzah Osman, Kahar Abdul Kadir, Mohammed Rafiq Abd. Aziz, Azian TA164 Bioengineering In this study, a three dimensional (3D) model of the third ventricle and aqueduct of Sylvius derived from MRI scans was constructed by using Computational Fluid Dynamics (CFD) modeling. Cerebrospinal fluid(CSF) can be modeled as a Newtonian Fluid and its flow through the region of interest (ROI) was visualized using Engineering Fluid Dynamics (EFD).The constructed ROI was regarded as rigid walled and only steady state flow was able to be defined due to the limitations of current software. Different flow rate was simulated at the Foramen of Monro and a small stenosis was modeled at the middle of the aqueduct of Sylvius at a fixed location. This was made corresponding to normal patients with variation of CSF flow rate physiologically and abnormal patients with tumor causing obstruction to or within the aqueduct of Sylvius, respectively. Due to the small dimensions of the ROI geometry, gravity and complex external gravity that acted upon it was considered to be neglected. The results show as the flow rate increase, the pressure drop of CSF in the ROI proportionally increased. For normal CSF flow rate, the presence of stenosis in the aqueduct demonstrates a significant increased pressure drop. IIUM Press 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/14201/1/Computational_Ix_on_CSF_Flow_Analysis._2011.pdf Hadzri, Edi Azali and Abdul Ghani, Ahmad Lufti and Shamsuddin, Amir Hamzah and Osman, Kahar and Abdul Kadir, Mohammed Rafiq and Abd. Aziz, Azian (2011) Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius. IIUM Engineering Journal, 12 (3). pp. 133-142. ISSN 1511-788X
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TA164 Bioengineering
spellingShingle	TA164 Bioengineering Hadzri, Edi Azali Abdul Ghani, Ahmad Lufti Shamsuddin, Amir Hamzah Osman, Kahar Abdul Kadir, Mohammed Rafiq Abd. Aziz, Azian Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius
description	In this study, a three dimensional (3D) model of the third ventricle and aqueduct of Sylvius derived from MRI scans was constructed by using Computational Fluid Dynamics (CFD) modeling. Cerebrospinal fluid(CSF) can be modeled as a Newtonian Fluid and its flow through the region of interest (ROI) was visualized using Engineering Fluid Dynamics (EFD).The constructed ROI was regarded as rigid walled and only steady state flow was able to be defined due to the limitations of current software. Different flow rate was simulated at the Foramen of Monro and a small stenosis was modeled at the middle of the aqueduct of Sylvius at a fixed location. This was made corresponding to normal patients with variation of CSF flow rate physiologically and abnormal patients with tumor causing obstruction to or within the aqueduct of Sylvius, respectively. Due to the small dimensions of the ROI geometry, gravity and complex external gravity that acted upon it was considered to be neglected. The results show as the flow rate increase, the pressure drop of CSF in the ROI proportionally increased. For normal CSF flow rate, the presence of stenosis in the aqueduct demonstrates a significant increased pressure drop.
format	Article
author	Hadzri, Edi Azali Abdul Ghani, Ahmad Lufti Shamsuddin, Amir Hamzah Osman, Kahar Abdul Kadir, Mohammed Rafiq Abd. Aziz, Azian
author_facet	Hadzri, Edi Azali Abdul Ghani, Ahmad Lufti Shamsuddin, Amir Hamzah Osman, Kahar Abdul Kadir, Mohammed Rafiq Abd. Aziz, Azian
author_sort	Hadzri, Edi Azali
title	Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius
title_short	Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius
title_full	Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius
title_fullStr	Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius
title_full_unstemmed	Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius
title_sort	computational investigation on csf flow analysis in the third ventricle and aqueduct of sylvius
publisher	IIUM Press
publishDate	2011
url	http://irep.iium.edu.my/14201/ http://irep.iium.edu.my/14201/1/Computational_Ix_on_CSF_Flow_Analysis._2011.pdf
first_indexed	2023-09-18T20:23:23Z
last_indexed	2023-09-18T20:23:23Z
_version_	1777408255786483712

Computational investigation on CSF flow analysis in the third ventricle and aqueduct of sylvius

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