Isolation and anticancer evaluation of mangostin from garcinia malaccensis

Garcinia malaccensis Hk.f (Guttiferae) is closely resembled to G. mangostana and G. hombroniana. The genus of Garcinia is well known as a medicinal plant in South-east Asia. The research investigated chemical constituents from the stembark of G. malaccensis together with their cytotoxic activity aga...

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Main Authors:	Bakhtiar, M. Taher, Mohamed, Farahidah
Format:	Monograph
Language:	English
Published:	IIUM 2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/14153/ http://irep.iium.edu.my/14153/1/FULL_PROJECT_REPORT-EDW1002-350.pdf

id	iium-14153
recordtype	eprints
spelling	iium-141532014-12-10T02:54:42Z http://irep.iium.edu.my/14153/ Isolation and anticancer evaluation of mangostin from garcinia malaccensis Bakhtiar, M. Taher Mohamed, Farahidah RS Pharmacy and materia medica Garcinia malaccensis Hk.f (Guttiferae) is closely resembled to G. mangostana and G. hombroniana. The genus of Garcinia is well known as a medicinal plant in South-east Asia. The research investigated chemical constituents from the stembark of G. malaccensis together with their cytotoxic activity against human cancer cell lines. Purification was carried out by chromatography technique on silica gel and the structures were established by various spectroscopic techniques. MTT assay and trypan blue exclusion method was performed to study cytotoxic activity of the compounds. The phytochemical study led to the isolation of -mangostinandcycloart-24-en-3-ol. -mangostin exhibited a significant cytotoxicity against human oral cancer (HSC-3) cells with an IC50 of 0.33 M. β- and α-mangostin significantly inhibited the proliferation of human chronic myelogenous leukemia (K562) cells with IC50 of 0.40 M and 0.48 M, respectively. However, none of the compounds exhibited activity against human non-small lung carcinoma (H1299) cells. IIUM 2011 Monograph NonPeerReviewed application/pdf en http://irep.iium.edu.my/14153/1/FULL_PROJECT_REPORT-EDW1002-350.pdf Bakhtiar, M. Taher and Mohamed, Farahidah (2011) Isolation and anticancer evaluation of mangostin from garcinia malaccensis. Project Report. IIUM, Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Bakhtiar, M. Taher Mohamed, Farahidah Isolation and anticancer evaluation of mangostin from garcinia malaccensis
description	Garcinia malaccensis Hk.f (Guttiferae) is closely resembled to G. mangostana and G. hombroniana. The genus of Garcinia is well known as a medicinal plant in South-east Asia. The research investigated chemical constituents from the stembark of G. malaccensis together with their cytotoxic activity against human cancer cell lines. Purification was carried out by chromatography technique on silica gel and the structures were established by various spectroscopic techniques. MTT assay and trypan blue exclusion method was performed to study cytotoxic activity of the compounds. The phytochemical study led to the isolation of -mangostinandcycloart-24-en-3-ol. -mangostin exhibited a significant cytotoxicity against human oral cancer (HSC-3) cells with an IC50 of 0.33 M. β- and α-mangostin significantly inhibited the proliferation of human chronic myelogenous leukemia (K562) cells with IC50 of 0.40 M and 0.48 M, respectively. However, none of the compounds exhibited activity against human non-small lung carcinoma (H1299) cells.
format	Monograph
author	Bakhtiar, M. Taher Mohamed, Farahidah
author_facet	Bakhtiar, M. Taher Mohamed, Farahidah
author_sort	Bakhtiar, M. Taher
title	Isolation and anticancer evaluation of mangostin from garcinia malaccensis
title_short	Isolation and anticancer evaluation of mangostin from garcinia malaccensis
title_full	Isolation and anticancer evaluation of mangostin from garcinia malaccensis
title_fullStr	Isolation and anticancer evaluation of mangostin from garcinia malaccensis
title_full_unstemmed	Isolation and anticancer evaluation of mangostin from garcinia malaccensis
title_sort	isolation and anticancer evaluation of mangostin from garcinia malaccensis
publisher	IIUM
publishDate	2011
url	http://irep.iium.edu.my/14153/ http://irep.iium.edu.my/14153/1/FULL_PROJECT_REPORT-EDW1002-350.pdf
first_indexed	2023-09-18T20:23:19Z
last_indexed	2023-09-18T20:23:19Z
_version_	1777408252210839552

Isolation and anticancer evaluation of mangostin from garcinia malaccensis

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