Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae)

Chemical investigation of the leaves of Garcinia griffithii(Guttiferae) has been carried out. The crude extract was obtained by using soxhlet extraction with n-hexane (n-Hexane) and methanol (MeOH) as the solvents. The MeOH crude exhact of the leaves of G. grifftthiiwere screened for antioxidant act...

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Main Authors:	Nik Sazali, Nik Shazwani Afifah, Ahmad, Farediah, Bakhtiar, M. Taher
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/13936/ http://irep.iium.edu.my/13936/ http://irep.iium.edu.my/13936/1/ICNP_SHAMSUL_SYAZWANI.pdf

id	iium-13936
recordtype	eprints
spelling	iium-139362014-12-09T01:31:03Z http://irep.iium.edu.my/13936/ Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae) Nik Sazali, Nik Shazwani Afifah Ahmad, Farediah Bakhtiar, M. Taher RS Pharmacy and materia medica Chemical investigation of the leaves of Garcinia griffithii(Guttiferae) has been carried out. The crude extract was obtained by using soxhlet extraction with n-hexane (n-Hexane) and methanol (MeOH) as the solvents. The MeOH crude exhact of the leaves of G. grifftthiiwere screened for antioxidant activity by DPPH method. The result suggested that the extract was potentialantioxidant agent. The crude MeOH extract of G. griffithiiwas found to show free radicalscavenging activity with (lCso = 2995.11 pg/ml). The results of totalphenolic content assays indicated that methanolic crude extract ior G. griffithii contained phenolic compounds. The total phenolic contents ol G. griffithii was expressed as pg gallic acid equivalent (GAE/L)(406.31 s 2.39 pg/ml)and pg (i)-cathechin equivalent (CEiL)(BB1.Bg r 5.56 pg/ml). The n-hexane extract was purified by using vacuum liquid chromatography (VLC) and column chromatography (CC) to get pure compounds. The structures were elucidated by spectroscopic techniques such as lR and NMR (1H, 13C and DEPT) spectroscopy and GC-MS. lsolation and characterization of the n-Hexane crude extract of G. oriffithiihave afforded soualene. friedooleanan-3-one and stigmasta-5-en-3-ol. 2011 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/13936/1/ICNP_SHAMSUL_SYAZWANI.pdf Nik Sazali, Nik Shazwani Afifah and Ahmad, Farediah and Bakhtiar, M. Taher (2011) Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae). In: International Conference on Natural Products (ICNP 2011): Metabolomics - A New Frontier in Natural Products Science, 14-16 November 2011, Putrajaya, Malaysia. http://www.icnp2011.upm.edu.my/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Nik Sazali, Nik Shazwani Afifah Ahmad, Farediah Bakhtiar, M. Taher Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae)
description	Chemical investigation of the leaves of Garcinia griffithii(Guttiferae) has been carried out. The crude extract was obtained by using soxhlet extraction with n-hexane (n-Hexane) and methanol (MeOH) as the solvents. The MeOH crude exhact of the leaves of G. grifftthiiwere screened for antioxidant activity by DPPH method. The result suggested that the extract was potentialantioxidant agent. The crude MeOH extract of G. griffithiiwas found to show free radicalscavenging activity with (lCso = 2995.11 pg/ml). The results of totalphenolic content assays indicated that methanolic crude extract ior G. griffithii contained phenolic compounds. The total phenolic contents ol G. griffithii was expressed as pg gallic acid equivalent (GAE/L)(406.31 s 2.39 pg/ml)and pg (i)-cathechin equivalent (CEiL)(BB1.Bg r 5.56 pg/ml). The n-hexane extract was purified by using vacuum liquid chromatography (VLC) and column chromatography (CC) to get pure compounds. The structures were elucidated by spectroscopic techniques such as lR and NMR (1H, 13C and DEPT) spectroscopy and GC-MS. lsolation and characterization of the n-Hexane crude extract of G. oriffithiihave afforded soualene. friedooleanan-3-one and stigmasta-5-en-3-ol.
format	Conference or Workshop Item
author	Nik Sazali, Nik Shazwani Afifah Ahmad, Farediah Bakhtiar, M. Taher
author_facet	Nik Sazali, Nik Shazwani Afifah Ahmad, Farediah Bakhtiar, M. Taher
author_sort	Nik Sazali, Nik Shazwani Afifah
title	Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae)
title_short	Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae)
title_full	Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae)
title_fullStr	Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae)
title_full_unstemmed	Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae)
title_sort	chemical constituents and biological activities of the leaves of garcinia griffithii(guttiferae)
publishDate	2011
url	http://irep.iium.edu.my/13936/ http://irep.iium.edu.my/13936/ http://irep.iium.edu.my/13936/1/ICNP_SHAMSUL_SYAZWANI.pdf
first_indexed	2023-09-18T20:23:07Z
last_indexed	2023-09-18T20:23:07Z
_version_	1777408239242051584

Chemical constituents and biological activities of the leaves of Garcinia griffithii(Guttiferae)

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