Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient for p53Ser46 phosphorylation
The p53 tumor suppressor protein plays key roles in protecting cells from tumorigenesis. Phosphorylation of p53 at Ser46 (p53Ser46) is considered to be a crucial modification regulating p53- mediated apoptosis. Because the activity of p53 is impaired in most human cancers, restoration of wild-type p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ELSEVIER
2012
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/13889/ http://irep.iium.edu.my/13889/ http://irep.iium.edu.my/13889/ http://irep.iium.edu.my/13889/1/Inability_of_p53-reactivating_compounds_Nutlin-3_and_RITA.pdf |