Assessment of redox status in children with attention deficit hyperactivity disorder

Attention deficit hyperactivity disorder (ADHD) is one of the most common neuro-behavioural disorders in children characterized by hyperactivity, impulsiveness and inattention beyond the norm for a child’s age. Oxidative injury is involved in many neurological disorders, however, not much is known a...

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Main Authors:	Saxena, Anil Kumar, Kukreja, Ruchi, Ali, Bashi, Sitholey, Prabhat, Gurtu, Sunil
Format:	Conference or Workshop Item
Language:	English
Published:	2009
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RJ Pediatrics
Online Access:	http://irep.iium.edu.my/13870/ http://irep.iium.edu.my/13870/ http://irep.iium.edu.my/13870/4/MSPP_2009.pdf

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recordtype	eprints
spelling	iium-138702012-01-04T07:05:14Z http://irep.iium.edu.my/13870/ Assessment of redox status in children with attention deficit hyperactivity disorder Saxena, Anil Kumar Kukreja, Ruchi Ali, Bashi Sitholey, Prabhat Gurtu, Sunil RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RJ Pediatrics Attention deficit hyperactivity disorder (ADHD) is one of the most common neuro-behavioural disorders in children characterized by hyperactivity, impulsiveness and inattention beyond the norm for a child’s age. Oxidative injury is involved in many neurological disorders, however, not much is known about the possible role of oxidative stress in the pathogenesis of ADHD. The present study was, therefore, designed to evaluate the antioxidant activity (AOA) of ADHD children as compared to age-matched healthy children by monitoring the antioxidant potential of saliva as a biomarker of oxidative stress. The subjects of the study were divided into Group I = Control (n=35); Group II = ADHD patients (n=47). Group II was subdivided into A. Pretreatment group comprising of Hyperactive-impulsive type (ADHD-HI; n=10), Inattentive type (ADHD-I; n=6), Combined type (ADHD-C; n=16) and B. Post-treatment group comprising of Short-term follow-up group (<3 months) and Long-term follow-up group (1-3 years). AOA in the pretreatment group and short-term post-treatment group was found to be significantly lower (0.86 ± 0.07 mM/l, 0.79 ± 0.18 nM/l, respectively) as compared to the control group (1.24 ± 0.08 nM/l). However the mean AOA in the long-term post-treatment group (1.30 ± 0.11 nM/l) did not show any significant difference as compared with the control group. The catalase activity in saliva showed a pattern similar to that of total AOA in the pre-treatment and long-term follow up groups. From the above it can be surmised that there is a decrease in the antioxidant capacity of the body in patients with of ADHD and it tends to recover towards control values after sustained drug therapy. Supplementation with antioxidant may provide additional benefits in these patients. 2009-05 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/13870/4/MSPP_2009.pdf Saxena, Anil Kumar and Kukreja, Ruchi and Ali, Bashi and Sitholey, Prabhat and Gurtu, Sunil (2009) Assessment of redox status in children with attention deficit hyperactivity disorder. In: 23rd MSPP Scientific Meeting, 12-13 May 2009, Grand Seasons Hotel, Kuala Lumpur. http://www.mspp.net.my/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RJ Pediatrics
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RJ Pediatrics Saxena, Anil Kumar Kukreja, Ruchi Ali, Bashi Sitholey, Prabhat Gurtu, Sunil Assessment of redox status in children with attention deficit hyperactivity disorder
description	Attention deficit hyperactivity disorder (ADHD) is one of the most common neuro-behavioural disorders in children characterized by hyperactivity, impulsiveness and inattention beyond the norm for a child’s age. Oxidative injury is involved in many neurological disorders, however, not much is known about the possible role of oxidative stress in the pathogenesis of ADHD. The present study was, therefore, designed to evaluate the antioxidant activity (AOA) of ADHD children as compared to age-matched healthy children by monitoring the antioxidant potential of saliva as a biomarker of oxidative stress. The subjects of the study were divided into Group I = Control (n=35); Group II = ADHD patients (n=47). Group II was subdivided into A. Pretreatment group comprising of Hyperactive-impulsive type (ADHD-HI; n=10), Inattentive type (ADHD-I; n=6), Combined type (ADHD-C; n=16) and B. Post-treatment group comprising of Short-term follow-up group (<3 months) and Long-term follow-up group (1-3 years). AOA in the pretreatment group and short-term post-treatment group was found to be significantly lower (0.86 ± 0.07 mM/l, 0.79 ± 0.18 nM/l, respectively) as compared to the control group (1.24 ± 0.08 nM/l). However the mean AOA in the long-term post-treatment group (1.30 ± 0.11 nM/l) did not show any significant difference as compared with the control group. The catalase activity in saliva showed a pattern similar to that of total AOA in the pre-treatment and long-term follow up groups. From the above it can be surmised that there is a decrease in the antioxidant capacity of the body in patients with of ADHD and it tends to recover towards control values after sustained drug therapy. Supplementation with antioxidant may provide additional benefits in these patients.
format	Conference or Workshop Item
author	Saxena, Anil Kumar Kukreja, Ruchi Ali, Bashi Sitholey, Prabhat Gurtu, Sunil
author_facet	Saxena, Anil Kumar Kukreja, Ruchi Ali, Bashi Sitholey, Prabhat Gurtu, Sunil
author_sort	Saxena, Anil Kumar
title	Assessment of redox status in children with attention deficit hyperactivity disorder
title_short	Assessment of redox status in children with attention deficit hyperactivity disorder
title_full	Assessment of redox status in children with attention deficit hyperactivity disorder
title_fullStr	Assessment of redox status in children with attention deficit hyperactivity disorder
title_full_unstemmed	Assessment of redox status in children with attention deficit hyperactivity disorder
title_sort	assessment of redox status in children with attention deficit hyperactivity disorder
publishDate	2009
url	http://irep.iium.edu.my/13870/ http://irep.iium.edu.my/13870/ http://irep.iium.edu.my/13870/4/MSPP_2009.pdf
first_indexed	2023-09-18T20:23:02Z
last_indexed	2023-09-18T20:23:02Z
_version_	1777408234007560192

Assessment of redox status in children with attention deficit hyperactivity disorder

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