Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study

Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study

The prevalence of Non-erosive reflux disease (NERD) is increasing in Asia. Dilated intercellular spaces (DIS) are considered as early signs of acid damage to the esophageal epithelium. There is little information available in the literature on the (DIS) of esophageal epithelium in NERD patients in M...

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Main Authors: Myint, Yi Yi, Tun, Ye, Mohammad Amjad, Nasser, Mat Hassan, Mohd. Zailani, Abdul Rashid, Nor Linda
Format: Article
Language:English
Published: Universiti Putra Malaysia 2011
Subjects:
QM Human anatomy
Online Access:http://irep.iium.edu.my/13767/
http://irep.iium.edu.my/13767/
http://irep.iium.edu.my/13767/1/NERD_article_in_EM_Journal_2011.pdf
id iium-13767
recordtype eprints
spelling iium-137672012-02-15T03:52:42Z http://irep.iium.edu.my/13767/ Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study Myint, Yi Yi Tun, Ye Mohammad Amjad, Nasser Mat Hassan, Mohd. Zailani Abdul Rashid, Nor Linda QM Human anatomy The prevalence of Non-erosive reflux disease (NERD) is increasing in Asia. Dilated intercellular spaces (DIS) are considered as early signs of acid damage to the esophageal epithelium. There is little information available in the literature on the (DIS) of esophageal epithelium in NERD patients in Malaysia. The aim of this study is to evaluate DIS of Malaysian patients with NERD and normal controls. The study group included 8 patients with reflux symptoms, normal mucosa on endoscopy and positive 24-hour pH monitoring and 5 normal controls. Specimens were taken 5 cm above the Z line during endoscopy. The biopsies were routinely processed for transmission electron microscopy (TEM). Morphometric analysis on microphotographs showed that mean intercellular space diameter values of NERD patient was significantly higher than normal controls (p<0.001). The maximal value of the mean intercellular spaces in controls and NERD were 0.44 μm and 1.13 μm respectively. There was no overlap between the two values, so the intermediate value 0.93 μm was considered as cut-off value. DIS at prickle cell layer is a promising diagnostic marker of early damage of esophageal epithelium. Universiti Putra Malaysia 2011 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/13767/1/NERD_article_in_EM_Journal_2011.pdf Myint, Yi Yi and Tun, Ye and Mohammad Amjad, Nasser and Mat Hassan, Mohd. Zailani and Abdul Rashid, Nor Linda (2011) Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study. Malaysian Journal of Microscopy, 7. pp. 87-91. ISSN 1823-7010 http://ibs.upm.edu.my/~aini/publications.htm
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QM Human anatomy
spellingShingle QM Human anatomy
Myint, Yi Yi
Tun, Ye
Mohammad Amjad, Nasser
Mat Hassan, Mohd. Zailani
Abdul Rashid, Nor Linda
Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study
description The prevalence of Non-erosive reflux disease (NERD) is increasing in Asia. Dilated intercellular spaces (DIS) are considered as early signs of acid damage to the esophageal epithelium. There is little information available in the literature on the (DIS) of esophageal epithelium in NERD patients in Malaysia. The aim of this study is to evaluate DIS of Malaysian patients with NERD and normal controls. The study group included 8 patients with reflux symptoms, normal mucosa on endoscopy and positive 24-hour pH monitoring and 5 normal controls. Specimens were taken 5 cm above the Z line during endoscopy. The biopsies were routinely processed for transmission electron microscopy (TEM). Morphometric analysis on microphotographs showed that mean intercellular space diameter values of NERD patient was significantly higher than normal controls (p<0.001). The maximal value of the mean intercellular spaces in controls and NERD were 0.44 μm and 1.13 μm respectively. There was no overlap between the two values, so the intermediate value 0.93 μm was considered as cut-off value. DIS at prickle cell layer is a promising diagnostic marker of early damage of esophageal epithelium.
format Article
author Myint, Yi Yi
Tun, Ye
Mohammad Amjad, Nasser
Mat Hassan, Mohd. Zailani
Abdul Rashid, Nor Linda
author_facet Myint, Yi Yi
Tun, Ye
Mohammad Amjad, Nasser
Mat Hassan, Mohd. Zailani
Abdul Rashid, Nor Linda
author_sort Myint, Yi Yi
title Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study
title_short Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study
title_full Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study
title_fullStr Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study
title_full_unstemmed Dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: Transmission electron microscopic (TEM) study
title_sort dilated intercellular spaces of esophageal epithelium in non- erosive reflux disease: transmission electron microscopic (tem) study
publisher Universiti Putra Malaysia
publishDate 2011
url http://irep.iium.edu.my/13767/
http://irep.iium.edu.my/13767/
http://irep.iium.edu.my/13767/1/NERD_article_in_EM_Journal_2011.pdf
first_indexed 2023-09-18T20:22:55Z
last_indexed 2023-09-18T20:22:55Z
_version_ 1777408226985246720

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