Free radical scavenging and antibacterial activities of Malaysian guttiferae plants

Guttiferae family is well known to have wide range of biological activities. The family is distributed throughout Malaysia, especially the genus of Calophyllum and Garcinia. Some of the species shows interesting bioactivity, such as Calophyllum lanigerum found in Borneo is exhibited anti- human immu...

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Main Authors:	Darnis, Deny Susanti, Bakhtiar, M. Taher, Nissad, Attoumani, Ahmad, Farediah
Format:	Article
Language:	English
Published:	Academic Journals 2011
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/13712/ http://irep.iium.edu.my/13712/ http://irep.iium.edu.my/13712/ http://irep.iium.edu.my/13712/1/Susanti_et_al.pdf

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recordtype	eprints
spelling	iium-137122014-12-09T00:25:40Z http://irep.iium.edu.my/13712/ Free radical scavenging and antibacterial activities of Malaysian guttiferae plants Darnis, Deny Susanti Bakhtiar, M. Taher Nissad, Attoumani Ahmad, Farediah RS Pharmacy and materia medica Guttiferae family is well known to have wide range of biological activities. The family is distributed throughout Malaysia, especially the genus of Calophyllum and Garcinia. Some of the species shows interesting bioactivity, such as Calophyllum lanigerum found in Borneo is exhibited anti- human immunodeficiency virus (HIV) properties. The study was conducted to determine the antioxidant and antibacterial activities of the extracts of selected Guttiferae collected in Malaysia. About 23 extract from different part of nine plants namely Calophyllum canum, Calophyllum depressinervosum, Calophyllum macrocarpum, Calophyllum teysmanii, Calophyllum symingtonianum, Garcinia griffithii, Garcinia prainiana, Garcinia malaccensis and Mesua grandis were tested for their free radical scavenging and antibacterial activities. Free radical scavenging activity was screened using dot blots 1, 1 -diphenyl-2-picrylhydrazyl (DPPH) staining and followed by DPPH free radical reaction. The antibacterial activity of these plant extracts was tested in vitro by using disc diffusion method and minimum inhibitory concentration (MIC). n-Hexane extract of the stem bark of G. griffithii showed higher scavenging activity with an IC50 of 0.09 mg/ml followed by n-hexane extract of the leaves of G. griffithii with an IC50 of 0.098 mg/ml. The antibacterial activity of the extracts revealed that the n-hexane extract of the stem bark of C. canum, C. teysmanii and M. grandis have the highest antibacterial effect with same MIC value at 0.25 mg/ml on the Bacillus cereus. Academic Journals 2011-12-23 Article PeerReviewed application/pdf en http://irep.iium.edu.my/13712/1/Susanti_et_al.pdf Darnis, Deny Susanti and Bakhtiar, M. Taher and Nissad, Attoumani and Ahmad, Farediah (2011) Free radical scavenging and antibacterial activities of Malaysian guttiferae plants. Journal of Medicinal Plants Research, 5 (31). pp. 6714-6718. ISSN 1996-0875 http://www.academicjournals.org/jmpr/contents/2011contentlist.htm 10.5897/JMPR11.678
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Darnis, Deny Susanti Bakhtiar, M. Taher Nissad, Attoumani Ahmad, Farediah Free radical scavenging and antibacterial activities of Malaysian guttiferae plants
description	Guttiferae family is well known to have wide range of biological activities. The family is distributed throughout Malaysia, especially the genus of Calophyllum and Garcinia. Some of the species shows interesting bioactivity, such as Calophyllum lanigerum found in Borneo is exhibited anti- human immunodeficiency virus (HIV) properties. The study was conducted to determine the antioxidant and antibacterial activities of the extracts of selected Guttiferae collected in Malaysia. About 23 extract from different part of nine plants namely Calophyllum canum, Calophyllum depressinervosum, Calophyllum macrocarpum, Calophyllum teysmanii, Calophyllum symingtonianum, Garcinia griffithii, Garcinia prainiana, Garcinia malaccensis and Mesua grandis were tested for their free radical scavenging and antibacterial activities. Free radical scavenging activity was screened using dot blots 1, 1 -diphenyl-2-picrylhydrazyl (DPPH) staining and followed by DPPH free radical reaction. The antibacterial activity of these plant extracts was tested in vitro by using disc diffusion method and minimum inhibitory concentration (MIC). n-Hexane extract of the stem bark of G. griffithii showed higher scavenging activity with an IC50 of 0.09 mg/ml followed by n-hexane extract of the leaves of G. griffithii with an IC50 of 0.098 mg/ml. The antibacterial activity of the extracts revealed that the n-hexane extract of the stem bark of C. canum, C. teysmanii and M. grandis have the highest antibacterial effect with same MIC value at 0.25 mg/ml on the Bacillus cereus.
format	Article
author	Darnis, Deny Susanti Bakhtiar, M. Taher Nissad, Attoumani Ahmad, Farediah
author_facet	Darnis, Deny Susanti Bakhtiar, M. Taher Nissad, Attoumani Ahmad, Farediah
author_sort	Darnis, Deny Susanti
title	Free radical scavenging and antibacterial activities of Malaysian guttiferae plants
title_short	Free radical scavenging and antibacterial activities of Malaysian guttiferae plants
title_full	Free radical scavenging and antibacterial activities of Malaysian guttiferae plants
title_fullStr	Free radical scavenging and antibacterial activities of Malaysian guttiferae plants
title_full_unstemmed	Free radical scavenging and antibacterial activities of Malaysian guttiferae plants
title_sort	free radical scavenging and antibacterial activities of malaysian guttiferae plants
publisher	Academic Journals
publishDate	2011
url	http://irep.iium.edu.my/13712/ http://irep.iium.edu.my/13712/ http://irep.iium.edu.my/13712/ http://irep.iium.edu.my/13712/1/Susanti_et_al.pdf
first_indexed	2023-09-18T20:22:51Z
last_indexed	2023-09-18T20:22:51Z
_version_	1777408222235197440

Free radical scavenging and antibacterial activities of Malaysian guttiferae plants

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