Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats

Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteri...

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Main Authors:	Saxena, Anil Kumar, Abdul Majeed, Saif Saad, Oothuman, Pakeer, Gurtu, Sunil
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://irep.iium.edu.my/13710/ http://irep.iium.edu.my/13710/ http://irep.iium.edu.my/13710/1/MSPP_25th.pdf

id	iium-13710
recordtype	eprints
spelling	iium-137102012-03-14T03:09:55Z http://irep.iium.edu.my/13710/ Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Gurtu, Sunil RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms which is thought to play a significant role in chronic degenerative neurological disorders. The present study was planned to assess the alterations in oxidative and anti-oxidant mechanisms that might occur during chronic cerebral hypoperfusion. Malondialdehyde (MDA) concentration and antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue after eight weeks of 2VO induction in rats. Results show an increased level of oxidative stress as reflected by significantly elevated levels of MDA, GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occur in response to increased oxidative stress following ischemic insult. 2011-05 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/13710/1/MSPP_25th.pdf Saxena, Anil Kumar and Abdul Majeed, Saif Saad and Oothuman, Pakeer and Gurtu, Sunil (2011) Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats. In: "Advances in drug development for a better well-being", 25th-26th May 2011, Faculty of Medicine and Health Sciences, UPM, Kuala Lumpur. http://www.anilkumar@iium.edu.com.my
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Gurtu, Sunil Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
description	Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer’s disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms which is thought to play a significant role in chronic degenerative neurological disorders. The present study was planned to assess the alterations in oxidative and anti-oxidant mechanisms that might occur during chronic cerebral hypoperfusion. Malondialdehyde (MDA) concentration and antioxidant enzymes namely glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were measured in the brain tissue after eight weeks of 2VO induction in rats. Results show an increased level of oxidative stress as reflected by significantly elevated levels of MDA, GPx, SOD, and catalase enzymes as compared with the control group. It is possible that compensatory rise in antioxidant enzymes occur in response to increased oxidative stress following ischemic insult.
format	Conference or Workshop Item
author	Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Gurtu, Sunil
author_facet	Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Gurtu, Sunil
author_sort	Saxena, Anil Kumar
title	Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_short	Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_full	Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_fullStr	Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_full_unstemmed	Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
title_sort	assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats
publishDate	2011
url	http://irep.iium.edu.my/13710/ http://irep.iium.edu.my/13710/ http://irep.iium.edu.my/13710/1/MSPP_25th.pdf
first_indexed	2023-09-18T20:22:51Z
last_indexed	2023-09-18T20:22:51Z
_version_	1777408222092591104

Assesment of oxidative stress in chronic cerebral hypoperfusion-induced neurodegeneration in rats

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