Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge

Organophosphates (OPs) are commonly used as pesticides in agriculture. They are hydrolyzed by paraoxonase (PON1) which is a high density lipoprotein (HDL) associated enzyme known for its function to hydrolyze OPs into a relatively harmless substance. PON1 is also known to prevent atherosclerosis by...

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Main Authors:	Abdullah, Nor Zamzila, Ishaka, Aminu, Samsuddin, Niza, Mohd Rus, Razman, Mohamed, Abdul Hadi
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RA1190 Toxicology RB Pathology
Online Access:	http://irep.iium.edu.my/13579/ http://irep.iium.edu.my/13579/1/IRIIE_2010_Organophosphate_%26_CAD.pdf

id	iium-13579
recordtype	eprints
spelling	iium-135792012-04-02T06:27:53Z http://irep.iium.edu.my/13579/ Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge Abdullah, Nor Zamzila Ishaka, Aminu Samsuddin, Niza Mohd Rus, Razman Mohamed, Abdul Hadi RA1190 Toxicology RB Pathology Organophosphates (OPs) are commonly used as pesticides in agriculture. They are hydrolyzed by paraoxonase (PON1) which is a high density lipoprotein (HDL) associated enzyme known for its function to hydrolyze OPs into a relatively harmless substance. PON1 is also known to prevent atherosclerosis by hydrolyzing oxidized-low density lipoprotein (ox-LDL) as well as preventing the accumulation of lipid peroxides on LDL. Reports showed low PON1 activity among OPs-exposed individuals, while low PON1 activity was associated with a high risk of coronary artery disease (CAD). The link between chronic OPs exposure and lipid parameters which are known risk factors of CAD has not yet been reported. This study aimed at comparing the activities of PON1 and lipid parameters (ox-LDL, TC, TG, LDL-C and HDL-C) between workers who are exposed to OPs and non-exposed comparative groups. A cross sectional study was carried among 53 selected pesticides sprayers from 4 farms in Kuantan who fulfilled the criteria and 50 control subjects who were age, ethnicity and income bracket-matched. Fasting serum samples were analyzed for TC, TG, LDL-C and HDL-C (lipid profiles), ox-LDL and PON1 activities after the hydrolysis of substrates paraoxon, phenylacetate and diazoxon. Results showed a significantly lower (p<0.05) diazoxonase activity (mean: 890.93vs 990.48 U/ml) and higher ox-LDL (median: 4.89 vs 2.83 mU/L) among the OPs-exposed group. The PON1 to ox-LDL ratio which probably reflect the ability of PON1 to hydrolyze ox-LDL were also significantly lower (p<0.001) among the OPs exposed group. There were no differences in lipid profiles (p>0.05) between the two groups. Our study suggested that OPs-exposed individuals might be predisposed to atherosclerosis and CAD through the decreased PON1 ability to hydrolyze ox-LDL but not through lipid profiles. A larger scale study is required to confirm our observation. 2011-02 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/13579/1/IRIIE_2010_Organophosphate_%26_CAD.pdf Abdullah, Nor Zamzila and Ishaka, Aminu and Samsuddin, Niza and Mohd Rus, Razman and Mohamed, Abdul Hadi (2011) Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2011, 9-10 February 2011, Cultural Activity Centre (CAC) and KAED Gallery IIUM. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RA1190 Toxicology RB Pathology
spellingShingle	RA1190 Toxicology RB Pathology Abdullah, Nor Zamzila Ishaka, Aminu Samsuddin, Niza Mohd Rus, Razman Mohamed, Abdul Hadi Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge
description	Organophosphates (OPs) are commonly used as pesticides in agriculture. They are hydrolyzed by paraoxonase (PON1) which is a high density lipoprotein (HDL) associated enzyme known for its function to hydrolyze OPs into a relatively harmless substance. PON1 is also known to prevent atherosclerosis by hydrolyzing oxidized-low density lipoprotein (ox-LDL) as well as preventing the accumulation of lipid peroxides on LDL. Reports showed low PON1 activity among OPs-exposed individuals, while low PON1 activity was associated with a high risk of coronary artery disease (CAD). The link between chronic OPs exposure and lipid parameters which are known risk factors of CAD has not yet been reported. This study aimed at comparing the activities of PON1 and lipid parameters (ox-LDL, TC, TG, LDL-C and HDL-C) between workers who are exposed to OPs and non-exposed comparative groups. A cross sectional study was carried among 53 selected pesticides sprayers from 4 farms in Kuantan who fulfilled the criteria and 50 control subjects who were age, ethnicity and income bracket-matched. Fasting serum samples were analyzed for TC, TG, LDL-C and HDL-C (lipid profiles), ox-LDL and PON1 activities after the hydrolysis of substrates paraoxon, phenylacetate and diazoxon. Results showed a significantly lower (p<0.05) diazoxonase activity (mean: 890.93vs 990.48 U/ml) and higher ox-LDL (median: 4.89 vs 2.83 mU/L) among the OPs-exposed group. The PON1 to ox-LDL ratio which probably reflect the ability of PON1 to hydrolyze ox-LDL were also significantly lower (p<0.001) among the OPs exposed group. There were no differences in lipid profiles (p>0.05) between the two groups. Our study suggested that OPs-exposed individuals might be predisposed to atherosclerosis and CAD through the decreased PON1 ability to hydrolyze ox-LDL but not through lipid profiles. A larger scale study is required to confirm our observation.
format	Conference or Workshop Item
author	Abdullah, Nor Zamzila Ishaka, Aminu Samsuddin, Niza Mohd Rus, Razman Mohamed, Abdul Hadi
author_facet	Abdullah, Nor Zamzila Ishaka, Aminu Samsuddin, Niza Mohd Rus, Razman Mohamed, Abdul Hadi
author_sort	Abdullah, Nor Zamzila
title	Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge
title_short	Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge
title_full	Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge
title_fullStr	Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge
title_full_unstemmed	Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge
title_sort	chronic organophosphate pesticide exposure and coronary artery disease : finding a bridge
publishDate	2011
url	http://irep.iium.edu.my/13579/ http://irep.iium.edu.my/13579/1/IRIIE_2010_Organophosphate_%26_CAD.pdf
first_indexed	2023-09-18T20:22:44Z
last_indexed	2023-09-18T20:22:44Z
_version_	1777408214698033152

Chronic Organophosphate Pesticide Exposure and Coronary Artery disease : finding a bridge

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