Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients

Changes affecting endothelial cells in the microcirculation of diabetic foot patients are important in the development of foot ulceration and subsequent failure to heal existing ulcers. Methods We studied 30 patients (10 control individuals, 10 with the neuropathic ulcer and 10 with neuroischa...

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Main Authors:	Radzuan, Hazulin, Myint, Yi Yi, Tun, Ye, Zulkifly, Ahmad Hafiz
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	QM Human anatomy
Online Access:	http://irep.iium.edu.my/13270/ http://irep.iium.edu.my/13270/1/poster_emsm.pdf

id	iium-13270
recordtype	eprints
spelling	iium-132702017-06-21T06:26:49Z http://irep.iium.edu.my/13270/ Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz QM Human anatomy Changes affecting endothelial cells in the microcirculation of diabetic foot patients are important in the development of foot ulceration and subsequent failure to heal existing ulcers. Methods We studied 30 patients (10 control individuals, 10 with the neuropathic ulcer and 10 with neuroischaemic ulcer). The specimens were taken using skin punch biopsy and were routinely processed for light microscopy. The mean endothelial cell count (ECC) was performed by calculating all the endothelial cells of the 3 selected arterioles in each slide of every patient. The mean endothelial cell thicknesses (ECT) of all endothelia were measured using the image analyzer. Results There were significant differences of ECC and ECT between the groups determined by one-way ANOVA (F(2,27) = 5.31, p = 0.01 and F(2,27) = 52.42, p < 0.01 respectivel)y. There was no significant differences of ECC and ECT between neuropathic and neuroischemic; p = 0.99 and p = 0.18 respectively. Conclusion The decrement of ECC and the increment of ECT among diabetic foot patients as compared to controls could be due to the alteration in the endothelial cell function and structure as the results of the metabolic disease. 2011-12-21 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/13270/1/poster_emsm.pdf Radzuan, Hazulin and Myint, Yi Yi and Tun, Ye and Zulkifly, Ahmad Hafiz (2011) Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients. In: 20th Scientific Conference of Microscopy Society of Malaysia , 20th to 22nd December 2011, Permaisuri resort, Port Dickson.
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QM Human anatomy
spellingShingle	QM Human anatomy Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients
description	Changes affecting endothelial cells in the microcirculation of diabetic foot patients are important in the development of foot ulceration and subsequent failure to heal existing ulcers. Methods We studied 30 patients (10 control individuals, 10 with the neuropathic ulcer and 10 with neuroischaemic ulcer). The specimens were taken using skin punch biopsy and were routinely processed for light microscopy. The mean endothelial cell count (ECC) was performed by calculating all the endothelial cells of the 3 selected arterioles in each slide of every patient. The mean endothelial cell thicknesses (ECT) of all endothelia were measured using the image analyzer. Results There were significant differences of ECC and ECT between the groups determined by one-way ANOVA (F(2,27) = 5.31, p = 0.01 and F(2,27) = 52.42, p < 0.01 respectivel)y. There was no significant differences of ECC and ECT between neuropathic and neuroischemic; p = 0.99 and p = 0.18 respectively. Conclusion The decrement of ECC and the increment of ECT among diabetic foot patients as compared to controls could be due to the alteration in the endothelial cell function and structure as the results of the metabolic disease.
format	Conference or Workshop Item
author	Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz
author_facet	Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz
author_sort	Radzuan, Hazulin
title	Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients
title_short	Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients
title_full	Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients
title_fullStr	Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients
title_full_unstemmed	Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients
title_sort	histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients
publishDate	2011
url	http://irep.iium.edu.my/13270/ http://irep.iium.edu.my/13270/1/poster_emsm.pdf
first_indexed	2023-09-18T20:22:27Z
last_indexed	2023-09-18T20:22:27Z
_version_	1777408197188911104

Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients

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