Development of magnesium-doped biphasic calcium phosphate through sol-gel method

Calcium phosphate is an interesting material for bone implant applications, as it shows biocompatibility and bioactivity to tissue bone. Among calcium phosphate-based materials, biphasic calcium phosphate (BCP), a mixture of non-resorbable hydroxyapatite (HA) and resorbable tricalcium phosphate (TCP...

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Main Authors:	Toibah, A. R., Sopyan, Iis, Abd Shukor, Mohd Hamdi, S., Ramesh
Format:	Conference or Workshop Item
Language:	English
Published:	2008
Subjects:	TA Engineering (General). Civil engineering (General)
Online Access:	http://irep.iium.edu.my/1289/ http://irep.iium.edu.my/1289/ http://irep.iium.edu.my/1289/1/Development_of_magnesium-doped_biphasic_calcium_phosphate_through_sol-gel_method.pdf

id	iium-1289
recordtype	eprints
spelling	iium-12892011-08-04T04:11:46Z http://irep.iium.edu.my/1289/ Development of magnesium-doped biphasic calcium phosphate through sol-gel method Toibah, A. R. Sopyan, Iis Abd Shukor, Mohd Hamdi S., Ramesh TA Engineering (General). Civil engineering (General) Calcium phosphate is an interesting material for bone implant applications, as it shows biocompatibility and bioactivity to tissue bone. Among calcium phosphate-based materials, biphasic calcium phosphate (BCP), a mixture of non-resorbable hydroxyapatite (HA) and resorbable tricalcium phosphate (TCP), has shown to possess unique characteristics appropriate for bone replacement. Doping of magnesium ions into BCP will bring biological improvement. Magnesium ion was found to cause the acceleration of nucleation kinetics of bone minerals. Magnesium depletion adversely affects all stages of skeletal metabolism, leading to decrease in osteoblastic activities and bone fragility. Therefore, the incorporation of magnesium ions into the calcium phosphate structure is of great interest for the development of artificial bone implants. Here we present magnesium-doped biphasic calcium phosphate (Mg-BCP) using chemical doping process through a solgel method. Mg-BCP was produced using calcium nitrate tetrahydrate and di-ammonium hydrogen phosphate as the precursors for calcium and phosphorus, respectively. Magnesium nitrate was used as the source of the dopant. An ammoniacal solution of the monomers was heated until a white gel was obtained. The obtained gel was then dried and subsequently subjected to calcinations. The change in physicochemical properties has been evaluated by using XRD, FTIR, TG/DTA, and FESEM. Individual particles are of less than 100 nm in size, spherical shapes and tightly agglomerated. XRD measurement shown that the powder is Mg-doped BCP with 100% purity, and crystallinity increased with increased of Mg content. FTIR spectroscopy measurement also showed that the increment of crystallinity is directly proportional to the amount of dopant leading to the conclusion that magnesium acts as a sintering additive. This result is in good agreement with the analysis of FESEM where the particles of the Mgdoped BCP are larger as the amount of dopant increased as a result of more progressive fusion of particles. 2008 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/1289/1/Development_of_magnesium-doped_biphasic_calcium_phosphate_through_sol-gel_method.pdf Toibah, A. R. and Sopyan, Iis and Abd Shukor, Mohd Hamdi and S., Ramesh (2008) Development of magnesium-doped biphasic calcium phosphate through sol-gel method. In: 4th Kuala Lumpur International Conference on Biomedical Engineering 2008, 25 – 28 June 2008, Kuala Lumpur, Malaysia. http://www.springerlink.com/content/h6315uj484687j3g/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	TA Engineering (General). Civil engineering (General)
spellingShingle	TA Engineering (General). Civil engineering (General) Toibah, A. R. Sopyan, Iis Abd Shukor, Mohd Hamdi S., Ramesh Development of magnesium-doped biphasic calcium phosphate through sol-gel method
description	Calcium phosphate is an interesting material for bone implant applications, as it shows biocompatibility and bioactivity to tissue bone. Among calcium phosphate-based materials, biphasic calcium phosphate (BCP), a mixture of non-resorbable hydroxyapatite (HA) and resorbable tricalcium phosphate (TCP), has shown to possess unique characteristics appropriate for bone replacement. Doping of magnesium ions into BCP will bring biological improvement. Magnesium ion was found to cause the acceleration of nucleation kinetics of bone minerals. Magnesium depletion adversely affects all stages of skeletal metabolism, leading to decrease in osteoblastic activities and bone fragility. Therefore, the incorporation of magnesium ions into the calcium phosphate structure is of great interest for the development of artificial bone implants. Here we present magnesium-doped biphasic calcium phosphate (Mg-BCP) using chemical doping process through a solgel method. Mg-BCP was produced using calcium nitrate tetrahydrate and di-ammonium hydrogen phosphate as the precursors for calcium and phosphorus, respectively. Magnesium nitrate was used as the source of the dopant. An ammoniacal solution of the monomers was heated until a white gel was obtained. The obtained gel was then dried and subsequently subjected to calcinations. The change in physicochemical properties has been evaluated by using XRD, FTIR, TG/DTA, and FESEM. Individual particles are of less than 100 nm in size, spherical shapes and tightly agglomerated. XRD measurement shown that the powder is Mg-doped BCP with 100% purity, and crystallinity increased with increased of Mg content. FTIR spectroscopy measurement also showed that the increment of crystallinity is directly proportional to the amount of dopant leading to the conclusion that magnesium acts as a sintering additive. This result is in good agreement with the analysis of FESEM where the particles of the Mgdoped BCP are larger as the amount of dopant increased as a result of more progressive fusion of particles.
format	Conference or Workshop Item
author	Toibah, A. R. Sopyan, Iis Abd Shukor, Mohd Hamdi S., Ramesh
author_facet	Toibah, A. R. Sopyan, Iis Abd Shukor, Mohd Hamdi S., Ramesh
author_sort	Toibah, A. R.
title	Development of magnesium-doped biphasic calcium phosphate through sol-gel method
title_short	Development of magnesium-doped biphasic calcium phosphate through sol-gel method
title_full	Development of magnesium-doped biphasic calcium phosphate through sol-gel method
title_fullStr	Development of magnesium-doped biphasic calcium phosphate through sol-gel method
title_full_unstemmed	Development of magnesium-doped biphasic calcium phosphate through sol-gel method
title_sort	development of magnesium-doped biphasic calcium phosphate through sol-gel method
publishDate	2008
url	http://irep.iium.edu.my/1289/ http://irep.iium.edu.my/1289/ http://irep.iium.edu.my/1289/1/Development_of_magnesium-doped_biphasic_calcium_phosphate_through_sol-gel_method.pdf
first_indexed	2023-09-18T20:08:32Z
last_indexed	2023-09-18T20:08:32Z
_version_	1777407321498976256

Development of magnesium-doped biphasic calcium phosphate through sol-gel method

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