Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing

Wounds due to injuries for various reasons and for the diabetic patients havebeen a major public health concern. In search for a wound healing agent of herbal origin, earlier we have reported the efficiency of the green (unripe) Carica papaya extracts (GPE) for wound healing [1]. Here we report that...

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Main Authors:	Akram, Haris B., Nuzwua, Dinie, Yusuf, Mohammed, Rahman, Mohammad Tariqur
Format:	Article
Language:	English
Published:	Wiley-Blackwell Publishing, INC, 2009
Subjects:	QH301 Biology QR Microbiology R Medicine (General) RL Dermatology
Online Access:	http://irep.iium.edu.my/12836/ http://irep.iium.edu.my/12836/ http://irep.iium.edu.my/12836/ http://irep.iium.edu.my/12836/4/wound_repair.pdf

id	iium-12836
recordtype	eprints
spelling	iium-128362012-01-03T23:50:26Z http://irep.iium.edu.my/12836/ Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing Akram, Haris B. Nuzwua, Dinie Yusuf, Mohammed Rahman, Mohammad Tariqur QH301 Biology QR Microbiology R Medicine (General) RL Dermatology Wounds due to injuries for various reasons and for the diabetic patients havebeen a major public health concern. In search for a wound healing agent of herbal origin, earlier we have reported the efficiency of the green (unripe) Carica papaya extracts (GPE) for wound healing [1]. Here we report that addition of zinc and selenium with GPE results in further improvement of wound healing efficiency. Induced epidermal wounds on mouse (n=5–7 for each group) were topically treated with GPE, prepared either in PBS or water as solvent. Zinc was added at concentration of 100Mand 200Mwhile selenium was added at a concentration of 2.5Mand 5M. Zinc addition at 100Mwas resulted in highest rate of wound healing compared to the addition of either 200M of Zn or Se (either at 2.5M or 5 M). During the first phase (0–4 days) of wound healing addition of 100M Zn to GPE resulted in about 50% reduction of the initial wound size (5mm diameter). During the same period of time, treatment with the GPE in combination with either 200M of Zn or 5M of Se as well as solcoseryl (commercially available wound healing agent) resulted in not more than 30% reduction of the initial wound size. Unlike solcoseryl treatment 100M of Zn added GPE did not show any sign of inflammation. Compared to the other groups of mice, complete hair growth on the area of regenerated skin was also significantly rapid in the mice treated with 100M of Zn. Wiley-Blackwell Publishing, INC, 2009-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12836/4/wound_repair.pdf Akram, Haris B. and Nuzwua, Dinie and Yusuf, Mohammed and Rahman, Mohammad Tariqur (2009) Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing. Wound Repair and Regeneration, 17 (4). A62. ISSN 1067-1927 http://onlinelibrary.wiley.com/doi/10.1111/j.1524-475X.2009.00519.x/abstract 10.1111/j.1524-475X.2009.00519.x
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QH301 Biology QR Microbiology R Medicine (General) RL Dermatology
spellingShingle	QH301 Biology QR Microbiology R Medicine (General) RL Dermatology Akram, Haris B. Nuzwua, Dinie Yusuf, Mohammed Rahman, Mohammad Tariqur Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing
description	Wounds due to injuries for various reasons and for the diabetic patients havebeen a major public health concern. In search for a wound healing agent of herbal origin, earlier we have reported the efficiency of the green (unripe) Carica papaya extracts (GPE) for wound healing [1]. Here we report that addition of zinc and selenium with GPE results in further improvement of wound healing efficiency. Induced epidermal wounds on mouse (n=5–7 for each group) were topically treated with GPE, prepared either in PBS or water as solvent. Zinc was added at concentration of 100Mand 200Mwhile selenium was added at a concentration of 2.5Mand 5M. Zinc addition at 100Mwas resulted in highest rate of wound healing compared to the addition of either 200M of Zn or Se (either at 2.5M or 5 M). During the first phase (0–4 days) of wound healing addition of 100M Zn to GPE resulted in about 50% reduction of the initial wound size (5mm diameter). During the same period of time, treatment with the GPE in combination with either 200M of Zn or 5M of Se as well as solcoseryl (commercially available wound healing agent) resulted in not more than 30% reduction of the initial wound size. Unlike solcoseryl treatment 100M of Zn added GPE did not show any sign of inflammation. Compared to the other groups of mice, complete hair growth on the area of regenerated skin was also significantly rapid in the mice treated with 100M of Zn.
format	Article
author	Akram, Haris B. Nuzwua, Dinie Yusuf, Mohammed Rahman, Mohammad Tariqur
author_facet	Akram, Haris B. Nuzwua, Dinie Yusuf, Mohammed Rahman, Mohammad Tariqur
author_sort	Akram, Haris B.
title	Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing
title_short	Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing
title_full	Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing
title_fullStr	Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing
title_full_unstemmed	Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing
title_sort	addition of zinc and selenium to papaya extract enhances its efficiency of wound healing
publisher	Wiley-Blackwell Publishing, INC,
publishDate	2009
url	http://irep.iium.edu.my/12836/ http://irep.iium.edu.my/12836/ http://irep.iium.edu.my/12836/ http://irep.iium.edu.my/12836/4/wound_repair.pdf
first_indexed	2023-09-18T20:21:59Z
last_indexed	2023-09-18T20:21:59Z
_version_	1777408168018575360

Addition of zinc and selenium to papaya extract enhances its efficiency of wound healing

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