Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent

α-Mangostin is one of the main active constituents that can be isolated from the stem bark of Garcinia malaccensis (GM) and has been documented to exert different cytotoxic activities against many cancerous cell lines. Due to its non selective distribution into the tissue, this study had attempted t...

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Main Authors:	Elsaid Ali, Aimen Abdo, Bakhtiar, M. Taher, Mohamed, Farahidah
Format:	Conference or Workshop Item
Language:	English
Published:	2011
Subjects:	RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/12374/ http://irep.iium.edu.my/12374/ http://irep.iium.edu.my/12374/1/IPBS_poster_%25282%2529.pdf

id	iium-12374
recordtype	eprints
spelling	iium-123742014-12-09T01:31:46Z http://irep.iium.edu.my/12374/ Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent Elsaid Ali, Aimen Abdo Bakhtiar, M. Taher Mohamed, Farahidah RM300 Drugs and their action RS Pharmacy and materia medica α-Mangostin is one of the main active constituents that can be isolated from the stem bark of Garcinia malaccensis (GM) and has been documented to exert different cytotoxic activities against many cancerous cell lines. Due to its non selective distribution into the tissue, this study had attempted to encapsulate the α-mangostin into biodegradable PLGA copolymer using colloidal extraction solvent evaporation method. The polysaccharide Chitosan was incorporated with the loaded nanoparticles to improve their affinity towards lung cancer cells. The resultant nanoparticles were characterized for their size distribution and external morphology by laser diffractometry and scanning electron microscope (SEM), respectively. The concentration of entrapped α-mangostin was determined by HPLC. Our data demonstrated that the encapsulation efficiency for Chitosan-α-mangostin-loaded PLGA nanoparticles (CM-NP) was higher than those without Chitosan (M-NP). The in vitro release from (CM-NP) and (NPM) was carried out in PBS containing 0.1% tween 20 over three weeks. Whereas, in vitro anti-cancer activities of (CM-NP) and (M-NP) were evaluated against lung cancer cell line (A549) and compared to the free α-mangostin. Our data revealed that (CM-NP) showed higher cytotoxic effect compared to (M-NP) and both had lower cytotoxicity than free α-mangostin. In conclusion, PLGA nanoparticles in combination with Chitosan may be used as a promising composite micro-carrier system to deliver α-mangostin to the lung cancer tissue. 2011 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/12374/1/IPBS_poster_%25282%2529.pdf Elsaid Ali, Aimen Abdo and Bakhtiar, M. Taher and Mohamed, Farahidah (2011) Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent. In: International Postgraduate Conference on Biotechnology (IPBC) 2011, 15-18 Dec 2011, Kuala Terengganu. http://imb.umt.edu.my/ipcb2011/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM300 Drugs and their action RS Pharmacy and materia medica
spellingShingle	RM300 Drugs and their action RS Pharmacy and materia medica Elsaid Ali, Aimen Abdo Bakhtiar, M. Taher Mohamed, Farahidah Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent
description	α-Mangostin is one of the main active constituents that can be isolated from the stem bark of Garcinia malaccensis (GM) and has been documented to exert different cytotoxic activities against many cancerous cell lines. Due to its non selective distribution into the tissue, this study had attempted to encapsulate the α-mangostin into biodegradable PLGA copolymer using colloidal extraction solvent evaporation method. The polysaccharide Chitosan was incorporated with the loaded nanoparticles to improve their affinity towards lung cancer cells. The resultant nanoparticles were characterized for their size distribution and external morphology by laser diffractometry and scanning electron microscope (SEM), respectively. The concentration of entrapped α-mangostin was determined by HPLC. Our data demonstrated that the encapsulation efficiency for Chitosan-α-mangostin-loaded PLGA nanoparticles (CM-NP) was higher than those without Chitosan (M-NP). The in vitro release from (CM-NP) and (NPM) was carried out in PBS containing 0.1% tween 20 over three weeks. Whereas, in vitro anti-cancer activities of (CM-NP) and (M-NP) were evaluated against lung cancer cell line (A549) and compared to the free α-mangostin. Our data revealed that (CM-NP) showed higher cytotoxic effect compared to (M-NP) and both had lower cytotoxicity than free α-mangostin. In conclusion, PLGA nanoparticles in combination with Chitosan may be used as a promising composite micro-carrier system to deliver α-mangostin to the lung cancer tissue.
format	Conference or Workshop Item
author	Elsaid Ali, Aimen Abdo Bakhtiar, M. Taher Mohamed, Farahidah
author_facet	Elsaid Ali, Aimen Abdo Bakhtiar, M. Taher Mohamed, Farahidah
author_sort	Elsaid Ali, Aimen Abdo
title	Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent
title_short	Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent
title_full	Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent
title_fullStr	Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent
title_full_unstemmed	Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent
title_sort	development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent
publishDate	2011
url	http://irep.iium.edu.my/12374/ http://irep.iium.edu.my/12374/ http://irep.iium.edu.my/12374/1/IPBS_poster_%25282%2529.pdf
first_indexed	2023-09-18T20:21:36Z
last_indexed	2023-09-18T20:21:36Z
_version_	1777408143363407872

Development of chitosan-α-mangostin loaded nanoparticles as an anticancer agent

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