Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system
Current global treatment for acute and chronic orthopaedic infection using non-biodegradable, antibiotic implant are costly and frequently disabling problem that severely affects the patient’s functional outcome and quality of life. Once infection is established, it requires multiple surgeries, pro...
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2011
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| Online Access: | http://irep.iium.edu.my/12363/ http://irep.iium.edu.my/12363/1/design_poster_microencapsulation_of-1.pdf |
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iium-123632013-01-14T06:40:38Z http://irep.iium.edu.my/12363/ Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system Mohamed, Farahidah Harun Ismail, Ahmad Fahmi Doolaane, Abd Monem RS Pharmacy and materia medica Current global treatment for acute and chronic orthopaedic infection using non-biodegradable, antibiotic implant are costly and frequently disabling problem that severely affects the patient’s functional outcome and quality of life. Once infection is established, it requires multiple surgeries, prolonged antibiotic treatment, and long-term complications. It was estimated that the average cost of care for implant removal, 6 weeks of parenteral antibiotics, and re-implantation is approximately USD50,000. Therefore, to mitigate the problems, the study here has come out with an innovative product and a cheaper option i.e. a biodegradable micro-carrier system to deliver the antibiotic gentamicin (treatment gold standard) intended as antibiotic implant. The study employed multiple-emulsion solvent evaporation fabrication method to microencapsulate the drug into biodegradable (PLGA) matrix. The gentamicin was found stable and active post-encapsulation with a prolonged release profile observed for a month. 2011 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/12363/1/design_poster_microencapsulation_of-1.pdf Mohamed, Farahidah and Harun Ismail, Ahmad Fahmi and Doolaane, Abd Monem (2011) Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system. In: Biomalaysia 2011 Conference & Exhibition And The 2011 Pacific Rim Summit, 21-23 Nov 2011, KLCC. |
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Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
RS Pharmacy and materia medica |
| spellingShingle |
RS Pharmacy and materia medica Mohamed, Farahidah Harun Ismail, Ahmad Fahmi Doolaane, Abd Monem Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system |
| description |
Current global treatment for acute and chronic orthopaedic
infection using non-biodegradable, antibiotic implant are costly and frequently disabling problem that severely affects the patient’s functional outcome and quality of life. Once infection is established, it requires multiple surgeries, prolonged antibiotic treatment, and long-term complications. It was estimated that the average cost of
care for implant removal, 6 weeks of parenteral antibiotics, and re-implantation is approximately USD50,000. Therefore, to mitigate the problems, the study here has come out with an innovative product and a cheaper option i.e. a biodegradable micro-carrier system to
deliver the antibiotic gentamicin (treatment gold standard) intended as antibiotic implant. The study employed multiple-emulsion solvent evaporation fabrication method to microencapsulate the drug into biodegradable (PLGA) matrix. The gentamicin was found stable and active post-encapsulation with a prolonged release profile observed
for a month. |
| format |
Conference or Workshop Item |
| author |
Mohamed, Farahidah Harun Ismail, Ahmad Fahmi Doolaane, Abd Monem |
| author_facet |
Mohamed, Farahidah Harun Ismail, Ahmad Fahmi Doolaane, Abd Monem |
| author_sort |
Mohamed, Farahidah |
| title |
Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system |
| title_short |
Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system |
| title_full |
Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system |
| title_fullStr |
Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system |
| title_full_unstemmed |
Microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system |
| title_sort |
microencapsulation of gentamicin into biodegradable polymer as a novel drug delivery system |
| publishDate |
2011 |
| url |
http://irep.iium.edu.my/12363/ http://irep.iium.edu.my/12363/1/design_poster_microencapsulation_of-1.pdf |
| first_indexed |
2023-09-18T20:21:35Z |
| last_indexed |
2023-09-18T20:21:35Z |
| _version_ |
1777408142487846912 |