Anti-inflammatory action of components from Melastoma malabathricum

Ethnic folklore or empirical therapeutic uses of plant parts have often provided the early indication of the possibility of discovering some pharmacologically active substance from a plant. Melastoma malabathricum L. (Melastomaceae), locally known as sendudok putih, is a small shrub. Traditiona...

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Main Authors:	Md Pisar, Mazura, Darnis, Deny Susanti, Mat Ali, Rasadah
Format:	Article
Language:	English
Published:	Informa Healthcare 2007
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/12166/ http://irep.iium.edu.my/12166/ http://irep.iium.edu.my/12166/ http://irep.iium.edu.my/12166/1/Pharmaceutical_Biology.pdf

id	iium-12166
recordtype	eprints
spelling	iium-121662012-05-29T00:27:46Z http://irep.iium.edu.my/12166/ Anti-inflammatory action of components from Melastoma malabathricum Md Pisar, Mazura Darnis, Deny Susanti Mat Ali, Rasadah Q Science (General) Ethnic folklore or empirical therapeutic uses of plant parts have often provided the early indication of the possibility of discovering some pharmacologically active substance from a plant. Melastoma malabathricum L. (Melastomaceae), locally known as sendudok putih, is a small shrub. Traditional medicinal uses include diarrhea, dysentery, ulcers, wound care, and piles. In the search for natural compounds useful against anti-inflammatory activity, a-amyrin, betulinic acid, and isolated flavonoids, including quercetin and quercitrin, were assessed in vitro by determining their inhibitory effects on platelet activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. The results indicated that quercetin, quercitrin, a-amyrin, and betulinic acid showed inhibition of PAF receptor binding with IC50 values of 33.0, 45.4, 20.0, and 22.2 mM, respectively. The IC50 values of these compounds were comparable to Cedrol (13.1 mM), which is a known PAF receptor antagonist. These results suggest that natural flavonoid and pentacyclic triterpenes from M. malabathricum possess selective antagonistic activity toward PAF and could be an attractive candidate as a natural anti-inflammatory compound. Informa Healthcare 2007 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12166/1/Pharmaceutical_Biology.pdf Md Pisar, Mazura and Darnis, Deny Susanti and Mat Ali, Rasadah (2007) Anti-inflammatory action of components from Melastoma malabathricum. Pharmaceutical Biology, 45 (5). pp. 372-375. ISSN 1388-0209 http://dx.doi.org/10.1080/13880200701214797 doi:10.1080/13880200701214797
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Md Pisar, Mazura Darnis, Deny Susanti Mat Ali, Rasadah Anti-inflammatory action of components from Melastoma malabathricum
description	Ethnic folklore or empirical therapeutic uses of plant parts have often provided the early indication of the possibility of discovering some pharmacologically active substance from a plant. Melastoma malabathricum L. (Melastomaceae), locally known as sendudok putih, is a small shrub. Traditional medicinal uses include diarrhea, dysentery, ulcers, wound care, and piles. In the search for natural compounds useful against anti-inflammatory activity, a-amyrin, betulinic acid, and isolated flavonoids, including quercetin and quercitrin, were assessed in vitro by determining their inhibitory effects on platelet activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. The results indicated that quercetin, quercitrin, a-amyrin, and betulinic acid showed inhibition of PAF receptor binding with IC50 values of 33.0, 45.4, 20.0, and 22.2 mM, respectively. The IC50 values of these compounds were comparable to Cedrol (13.1 mM), which is a known PAF receptor antagonist. These results suggest that natural flavonoid and pentacyclic triterpenes from M. malabathricum possess selective antagonistic activity toward PAF and could be an attractive candidate as a natural anti-inflammatory compound.
format	Article
author	Md Pisar, Mazura Darnis, Deny Susanti Mat Ali, Rasadah
author_facet	Md Pisar, Mazura Darnis, Deny Susanti Mat Ali, Rasadah
author_sort	Md Pisar, Mazura
title	Anti-inflammatory action of components from Melastoma malabathricum
title_short	Anti-inflammatory action of components from Melastoma malabathricum
title_full	Anti-inflammatory action of components from Melastoma malabathricum
title_fullStr	Anti-inflammatory action of components from Melastoma malabathricum
title_full_unstemmed	Anti-inflammatory action of components from Melastoma malabathricum
title_sort	anti-inflammatory action of components from melastoma malabathricum
publisher	Informa Healthcare
publishDate	2007
url	http://irep.iium.edu.my/12166/ http://irep.iium.edu.my/12166/ http://irep.iium.edu.my/12166/ http://irep.iium.edu.my/12166/1/Pharmaceutical_Biology.pdf
first_indexed	2023-09-18T20:21:24Z
last_indexed	2023-09-18T20:21:24Z
_version_	1777408131666542592

Anti-inflammatory action of components from Melastoma malabathricum

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