Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats

Punica granatum L. (Punicaceae) peels extract had the highest free radical scavenging capacity among the tested medicinal plants which are being used traditionally for treatment of diabetes in Jordan. Accordingly, the present study aimed to investigate the antioxidant effect of P. granatum peel meth...

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Main Authors:	Althunibat, Osama Yousef, H. Al-Mustafa, Ahmed, Tarawneh, Khaled, M. Khleifat, Khaled, Hashim, Ridzwan, Qaralleh, Haitham
Format:	Article
Language:	English
Published:	ELSEVIER 2010
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/12087/ http://irep.iium.edu.my/12087/ http://irep.iium.edu.my/12087/1/Protective_role_of_Punica_granatum_L._peel_extract_against_oxidative_damage_in.pdf

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recordtype	eprints
spelling	iium-120872016-03-04T07:47:50Z http://irep.iium.edu.my/12087/ Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats Althunibat, Osama Yousef H. Al-Mustafa, Ahmed Tarawneh, Khaled M. Khleifat, Khaled Hashim, Ridzwan Qaralleh, Haitham Qaralleh, Haitham Q Science (General) Punica granatum L. (Punicaceae) peels extract had the highest free radical scavenging capacity among the tested medicinal plants which are being used traditionally for treatment of diabetes in Jordan. Accordingly, the present study aimed to investigate the antioxidant effect of P. granatum peel methanolic extract against oxidative damage in streptozotocin-induced diabetic rats. The antioxidant activity of P. granatum peel extract was investigated by examining the level of antioxidant enzymes, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR), the serum total antioxidant capacity and lipid peroxidation in the tissues of treated diabetic rates comparing with normal and untreated diabetic ones. The results revealed that intraperitoneal administration of 10 and 20 mg kg−1 (body weight) of P. granatum peel extract for 4 weeks significantly enhanced the activities of antioxidant enzymes in liver, kidney and RBC of STZ-induced diabetic rats. The extract also caused a significant reduction in malondialdehyde (MDA), a lipid peroxide's marker, in diabetic rat tissues and elevated the total serum antioxidant capacity in dose-dependent manner. In conclusion, this study clearly showed that P. granatum peel extract has protective role against the oxidative damage in STZ-induced diabetic rats. ELSEVIER 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12087/1/Protective_role_of_Punica_granatum_L._peel_extract_against_oxidative_damage_in.pdf Althunibat, Osama Yousef and H. Al-Mustafa, Ahmed and Tarawneh, Khaled and M. Khleifat, Khaled and Hashim, Ridzwan and Qaralleh, Haitham and Qaralleh, Haitham (2010) Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats. Process Biochemistry, 45 (4). pp. 581-585. ISSN 1359-5113 http://www.sciencedirect.com/science/article/pii/S1359511309003869
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Althunibat, Osama Yousef H. Al-Mustafa, Ahmed Tarawneh, Khaled M. Khleifat, Khaled Hashim, Ridzwan Qaralleh, Haitham Qaralleh, Haitham Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats
description	Punica granatum L. (Punicaceae) peels extract had the highest free radical scavenging capacity among the tested medicinal plants which are being used traditionally for treatment of diabetes in Jordan. Accordingly, the present study aimed to investigate the antioxidant effect of P. granatum peel methanolic extract against oxidative damage in streptozotocin-induced diabetic rats. The antioxidant activity of P. granatum peel extract was investigated by examining the level of antioxidant enzymes, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR), the serum total antioxidant capacity and lipid peroxidation in the tissues of treated diabetic rates comparing with normal and untreated diabetic ones. The results revealed that intraperitoneal administration of 10 and 20 mg kg−1 (body weight) of P. granatum peel extract for 4 weeks significantly enhanced the activities of antioxidant enzymes in liver, kidney and RBC of STZ-induced diabetic rats. The extract also caused a significant reduction in malondialdehyde (MDA), a lipid peroxide's marker, in diabetic rat tissues and elevated the total serum antioxidant capacity in dose-dependent manner. In conclusion, this study clearly showed that P. granatum peel extract has protective role against the oxidative damage in STZ-induced diabetic rats.
format	Article
author	Althunibat, Osama Yousef H. Al-Mustafa, Ahmed Tarawneh, Khaled M. Khleifat, Khaled Hashim, Ridzwan Qaralleh, Haitham Qaralleh, Haitham
author_facet	Althunibat, Osama Yousef H. Al-Mustafa, Ahmed Tarawneh, Khaled M. Khleifat, Khaled Hashim, Ridzwan Qaralleh, Haitham Qaralleh, Haitham
author_sort	Althunibat, Osama Yousef
title	Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats
title_short	Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats
title_full	Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats
title_fullStr	Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats
title_full_unstemmed	Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats
title_sort	protective role of punica granatum l. peel extract against oxidative damage in experimental diabetic rats
publisher	ELSEVIER
publishDate	2010
url	http://irep.iium.edu.my/12087/ http://irep.iium.edu.my/12087/ http://irep.iium.edu.my/12087/1/Protective_role_of_Punica_granatum_L._peel_extract_against_oxidative_damage_in.pdf
first_indexed	2023-09-18T20:21:19Z
last_indexed	2023-09-18T20:21:19Z
_version_	1777408125478895616

Protective role of Punica granatum L. peel extract against oxidative damage in experimental diabetic rats

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