Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum

Chemical investigation of Garcinia eugenifolia and Calophyllum enervosum yielded six compounds. One of these was found to be a novel compound identified as enervosanone. Five known compounds cambogin, epicatechin, osajaxanthone, rubraxanthone and isocowanol, were also isolated. These compounds were...

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Main Authors:	Bakhtiar, M. Taher, Muhammad Sum , Idris, Dayar, Arbain
Format:	Article
Language:	English
Published:	Razi Institute for Drug Research of IUMS 2007
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/12077/ http://irep.iium.edu.my/12077/ http://irep.iium.edu.my/12077/1/ijpt.pdf

id	iium-12077
recordtype	eprints
spelling	iium-120772014-12-09T00:26:26Z http://irep.iium.edu.my/12077/ Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum Bakhtiar, M. Taher Muhammad Sum , Idris Dayar, Arbain RS Pharmacy and materia medica Chemical investigation of Garcinia eugenifolia and Calophyllum enervosum yielded six compounds. One of these was found to be a novel compound identified as enervosanone. Five known compounds cambogin, epicatechin, osajaxanthone, rubraxanthone and isocowanol, were also isolated. These compounds were tested for their bioactivity as antimicrobial, antioxidant and cytotoxicagents. Antimicrobial assay was performed using disc diffusion method. The antioxidative activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method by electron spin resonance. The cytotoxicity was measured by the MTT assay against MCF7 cell line. Enervosanone and rubraxanthone were active against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus with MIC value of 26.82, 26.82, 26.82, 26.82 and 60.97, 30.48, 60.97, 60.97 mM, respectively. Rubraxanthone and epicatechin exhibited antioxidant activities with IC50 of 0.89 mM and 2.6 mM, respectively. The cytotoxicity assay on MCF7 cell line showed that enervosanone was found to be active in inhibiting cell proliferation of MCF7 with IC50 of 1.07 mM. Razi Institute for Drug Research of IUMS 2007 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12077/1/ijpt.pdf Bakhtiar, M. Taher and Muhammad Sum , Idris and Dayar, Arbain (2007) Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum. Iranian Journal of Pharmacology and Therapeutics, 6. pp. 93-98. ISSN 1735-2657 http://ijpt.tums.ac.ir/index.php/ijpt/index
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Bakhtiar, M. Taher Muhammad Sum , Idris Dayar, Arbain Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum
description	Chemical investigation of Garcinia eugenifolia and Calophyllum enervosum yielded six compounds. One of these was found to be a novel compound identified as enervosanone. Five known compounds cambogin, epicatechin, osajaxanthone, rubraxanthone and isocowanol, were also isolated. These compounds were tested for their bioactivity as antimicrobial, antioxidant and cytotoxicagents. Antimicrobial assay was performed using disc diffusion method. The antioxidative activity was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method by electron spin resonance. The cytotoxicity was measured by the MTT assay against MCF7 cell line. Enervosanone and rubraxanthone were active against Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus with MIC value of 26.82, 26.82, 26.82, 26.82 and 60.97, 30.48, 60.97, 60.97 mM, respectively. Rubraxanthone and epicatechin exhibited antioxidant activities with IC50 of 0.89 mM and 2.6 mM, respectively. The cytotoxicity assay on MCF7 cell line showed that enervosanone was found to be active in inhibiting cell proliferation of MCF7 with IC50 of 1.07 mM.
format	Article
author	Bakhtiar, M. Taher Muhammad Sum , Idris Dayar, Arbain
author_facet	Bakhtiar, M. Taher Muhammad Sum , Idris Dayar, Arbain
author_sort	Bakhtiar, M. Taher
title	Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum
title_short	Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum
title_full	Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum
title_fullStr	Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum
title_full_unstemmed	Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum
title_sort	antimicrobial, antioxidant, anti-inflammatory and cytotoxic activities of garcinia eugenifolia and calophyllum enervosum
publisher	Razi Institute for Drug Research of IUMS
publishDate	2007
url	http://irep.iium.edu.my/12077/ http://irep.iium.edu.my/12077/ http://irep.iium.edu.my/12077/1/ijpt.pdf
first_indexed	2023-09-18T20:21:18Z
last_indexed	2023-09-18T20:21:18Z
_version_	1777408124453388288

Antimicrobial, Antioxidant, Anti-Inflammatory and Cytotoxic Activities of Garcinia Eugenifolia and Calophyllum Enervosum

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