Mangostins and their bioactivities from garcinia Malaccensis HK.F

Introduction: Guttiferae is a well-known family having a wide range of phytochemical constituents and bioactivities. Objectives: To investigate phytochemicals and bioactivities of Garcinia malaccensis. Materials and Methods: The isolated compounds were elucidated by spectroscopic methods. Antimicr...

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Main Authors:	Bakhtiar, M. Taher, Darnis, Deny Susanti, Ahmad Zohri, Farah Syahidah, Arief Ichwan, Solachuddin Jauhari, Rezali, Mohd Fazlin
Format:	Article
Language:	English
Published:	Penerbit USM 2010
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/12061/ http://irep.iium.edu.my/12061/ http://irep.iium.edu.my/12061/1/Mangostins_and_their_bioactivies_from_Garcinia_malaccensis_HK.F.pdf

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recordtype	eprints
spelling	iium-120612012-03-13T00:20:57Z http://irep.iium.edu.my/12061/ Mangostins and their bioactivities from garcinia Malaccensis HK.F Bakhtiar, M. Taher Darnis, Deny Susanti Ahmad Zohri, Farah Syahidah Arief Ichwan, Solachuddin Jauhari Rezali, Mohd Fazlin RS Pharmacy and materia medica Introduction: Guttiferae is a well-known family having a wide range of phytochemical constituents and bioactivities. Objectives: To investigate phytochemicals and bioactivities of Garcinia malaccensis. Materials and Methods: The isolated compounds were elucidated by spectroscopic methods. Antimicrobial activity was carried out by disc diffusion method. Antiproliferative activity was performed by tryphan blue exclusion and MTT assay. Antioxidant activity was conducted by DPPH radical scavenging. Results: Phytochemicals investigation of the stem bark of G. malaccensis lead to isolation of -mangostin, -mangostin and a triterpenoid. The main priority of this study’s activity was done on -mangostin as the compound was found as a major constituent. Results showed that -mangostin inhibits Staphylococcus aureus. The diameter of inhibition zone observed was 8 mm, minimum inhibition concentration (MIC) was 0.025 mg/mL and minimum bactericidal concentration (MBC) was 0.1 mg/mL. Dot-blot DPPH staining showed a positive antioxidant activity of -mangostin. In FTC method, -mangostin was proved to be a good lipid peroxidation inhibitor, whereas in DPPH free radical scavenging activity method, it has a very weak scavenging effects on free radicals. In the antiproliferative assay, -mangostin exhibited activity against K562 (IC50 20 μg/mL) and showed a weak activity against HSC3 and H1299 cell lines. Penerbit USM 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12061/1/Mangostins_and_their_bioactivies_from_Garcinia_malaccensis_HK.F.pdf Bakhtiar, M. Taher and Darnis, Deny Susanti and Ahmad Zohri, Farah Syahidah and Arief Ichwan, Solachuddin Jauhari and Rezali, Mohd Fazlin (2010) Mangostins and their bioactivities from garcinia Malaccensis HK.F. Malaysian Journal of Pharmaceutical Sciences, 8 (sup.1). p. 13. ISSN 1675-7319 http://web.usm.my/mjps/vol_8%20supp1.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Bakhtiar, M. Taher Darnis, Deny Susanti Ahmad Zohri, Farah Syahidah Arief Ichwan, Solachuddin Jauhari Rezali, Mohd Fazlin Mangostins and their bioactivities from garcinia Malaccensis HK.F
description	Introduction: Guttiferae is a well-known family having a wide range of phytochemical constituents and bioactivities. Objectives: To investigate phytochemicals and bioactivities of Garcinia malaccensis. Materials and Methods: The isolated compounds were elucidated by spectroscopic methods. Antimicrobial activity was carried out by disc diffusion method. Antiproliferative activity was performed by tryphan blue exclusion and MTT assay. Antioxidant activity was conducted by DPPH radical scavenging. Results: Phytochemicals investigation of the stem bark of G. malaccensis lead to isolation of -mangostin, -mangostin and a triterpenoid. The main priority of this study’s activity was done on -mangostin as the compound was found as a major constituent. Results showed that -mangostin inhibits Staphylococcus aureus. The diameter of inhibition zone observed was 8 mm, minimum inhibition concentration (MIC) was 0.025 mg/mL and minimum bactericidal concentration (MBC) was 0.1 mg/mL. Dot-blot DPPH staining showed a positive antioxidant activity of -mangostin. In FTC method, -mangostin was proved to be a good lipid peroxidation inhibitor, whereas in DPPH free radical scavenging activity method, it has a very weak scavenging effects on free radicals. In the antiproliferative assay, -mangostin exhibited activity against K562 (IC50 20 μg/mL) and showed a weak activity against HSC3 and H1299 cell lines.
format	Article
author	Bakhtiar, M. Taher Darnis, Deny Susanti Ahmad Zohri, Farah Syahidah Arief Ichwan, Solachuddin Jauhari Rezali, Mohd Fazlin
author_facet	Bakhtiar, M. Taher Darnis, Deny Susanti Ahmad Zohri, Farah Syahidah Arief Ichwan, Solachuddin Jauhari Rezali, Mohd Fazlin
author_sort	Bakhtiar, M. Taher
title	Mangostins and their bioactivities from garcinia Malaccensis HK.F
title_short	Mangostins and their bioactivities from garcinia Malaccensis HK.F
title_full	Mangostins and their bioactivities from garcinia Malaccensis HK.F
title_fullStr	Mangostins and their bioactivities from garcinia Malaccensis HK.F
title_full_unstemmed	Mangostins and their bioactivities from garcinia Malaccensis HK.F
title_sort	mangostins and their bioactivities from garcinia malaccensis hk.f
publisher	Penerbit USM
publishDate	2010
url	http://irep.iium.edu.my/12061/ http://irep.iium.edu.my/12061/ http://irep.iium.edu.my/12061/1/Mangostins_and_their_bioactivies_from_Garcinia_malaccensis_HK.F.pdf
first_indexed	2023-09-18T20:21:16Z
last_indexed	2023-09-18T20:21:16Z
_version_	1777408123184611328

Mangostins and their bioactivities from garcinia Malaccensis HK.F

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